Abstract: The present invention relates generally to medicine. More specifically the invention relates to the use of synergistic probiotic bacteria as intervention for health. In particular, the present invention provides a strain of Faecalibacterium prausnitzii and a bacterial strain which has one or more of the characteristics of: (i) being acetate producing, (ii) being lactate consuming and (iii) having the ability to be an electron acceptor, for use in the treatment or prevention of a disease associated with reduced butyrate levels or a disease associated with reduced or low numbers of Faecalibacterium prausnitzii bacteria.

Abstract: The present invention relates generally to growth of bacteria. More specifically the invention relates to a method for oxidative environment adaptation of anaerobic microorganisms and their use in developing new probiotics. In particular, the present invention provides a method for adaptation of anaerobic microorganisms and selection of more oxygen tolerant anaerobic microorganisms, said method comprising the steps of culturing said microorganisms with a stepwise dual induction of oxidative stress via applied voltage and oxygen diffusion, and a stepwise change of anti-oxidant/oxidized counterpart concentration ratio to adjust the redox state. New strains are also provided.

Abstract: The present invention relates to the identification of a person having risk for developing type 2 diabetes (T2D) by determining the presence or absence of specific genes, gene clusters, genera or species of bacteria in the person's gastrointestinal microbiota. More specifically the invention relates to a model to identify an individual having or at risk of developing type 2 diabetes (T2D) using metagenomic clusters (MGCs), wherein said model is characterized by using different metagenomic clusters for different population groups. Also provided is the use of such a model in the identification of a person having risk for developing type 2 diabetes (T2D).