Patents Assigned to MetaBolex, Inc.
  • Pancreatic islet transcription factor and uses thereof
    Publication number: 20060264611
    Abstract: The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes.
    Type: Application
    Filed: November 13, 2003
    Publication date: November 23, 2006
    Applicant: Metabolex, Inc
    Inventors: Jeffrey Johnson, John Palma, Anthony Schweitzer, John Blume
  • Substituted phenylacetic acids
    Publication number: 20060264630
    Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
    Type: Application
    Filed: January 4, 2006
    Publication date: November 23, 2006
    Applicant: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Liang
  • Compositions and methods of using apoptosis signaling kinase related kinase (ASKRK)
    Publication number: 20060252100
    Abstract: The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of ASKRK nucleic acids and proteins.
    Type: Application
    Filed: July 17, 2006
    Publication date: November 9, 2006
    Applicant: Metabolex, Inc.
    Inventors: Jeffrey Johnson, Yun-Ping Zhou, Kimberly Marlen
  • CD39L3 and its role in diabetes
    Publication number: 20060246006
    Abstract: The present invention provides for methods and compositions related to the involvement of CD39L3 in insulin production.
    Type: Application
    Filed: April 10, 2006
    Publication date: November 2, 2006
    Applicant: METABOLEX, INC.
    Inventors: Jeffrey Johnson, Yuko Terasawa, Maria Wilson
  • Methods of diagnosing and treating diabetes and insulin resistance
    Publication number: 20060228706
    Abstract: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
    Type: Application
    Filed: June 4, 2003
    Publication date: October 12, 2006
    Applicant: Metabolex, Inc.
    Inventors: Allan Bernard, Brian Lavan, Shonna Moodie, Steve Waters, Chi-Wai Wong
  • Compositions and methods for preventing, treating and diagnosing diabetes
    Publication number: 20060210974
    Abstract: The invention provides methods and compositions for preventing, treating and diagnosing diabetes.
    Type: Application
    Filed: June 13, 2003
    Publication date: September 21, 2006
    Applicant: Metabolex, Inc.
    Inventors: Shonna Moodie, Thomas Gustafson, Chi-Wai Wong
  • Compositions and methods of using apoptosis signaling kinase related kinase (ASKRK)
    Patent number: 7109021
    Abstract: The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of ASKRK nucleic acids and proteins.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: September 19, 2006
    Assignee: Metabolex, Inc.
    Inventors: Jeffrey D. Johnson, Yun-Ping Zhou, Kimberly Marlen
  • Methods and compositions for treating and diagnosing diabetes and related diseases involving beta-TRP
    Patent number: 7087394
    Abstract: Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose-stimulated insulin production.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: August 8, 2006
    Assignee: Metabolex, Inc.
    Inventors: Jeffrey D. Johnson, Yun-Ping Zhou
  • Substituted phenylacetic acids
    Patent number: 7078421
    Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: July 18, 2006
    Assignee: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
  • Polynucleotides encoding potassium channels
    Publication number: 20060148037
    Abstract: The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes.
    Type: Application
    Filed: March 3, 2006
    Publication date: July 6, 2006
    Applicant: METABOLEX, INC.
    Inventors: Jeffrey Johnson, John Palma, Anthony Schweitzer, John Blume
  • Isolated islet beta-cell two-pore domain potassium channel
    Patent number: 7053180
    Abstract: The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: May 30, 2006
    Assignee: Metabolex, Inc.
    Inventors: Jeffrey D. Johnson, John F. Palma, Anthony C. Schweitzer, John E. Blume
  • Methods of diagnosing & treating diabetes and insulin resistance
    Publication number: 20060074018
    Abstract: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
    Type: Application
    Filed: June 4, 2003
    Publication date: April 6, 2006
    Applicant: Metabolex Inc
    Inventors: Allan Bernard, Francine Gregoire, Brian Lavan, Shonna Moodie
  • Modulators of PPAR and methods of their preparation
    Publication number: 20060058301
    Abstract: The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.
    Type: Application
    Filed: August 11, 2005
    Publication date: March 16, 2006
    Applicant: Metabolex, Inc.
    Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine Gregoire, Vera Rakhmanova
  • Substituted triazoles as modulators of PPAR and methods of their preparation
    Publication number: 20060014809
    Abstract: The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
    Type: Application
    Filed: May 24, 2005
    Publication date: January 19, 2006
    Applicant: Metabolex, Inc.
    Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine Gregoire, Vera Rakhmanova
  • BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    Publication number: 20060014785
    Abstract: The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
    Type: Application
    Filed: May 24, 2005
    Publication date: January 19, 2006
    Applicant: Metabolex, Inc.
    Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine Gregoire, Vera Rakhmanova
  • Compositions and methods of using apoptosis signaling kinase related kinase (ASKRK)
    Publication number: 20050233347
    Abstract: The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of ASKRK nucleic acids and proteins.
    Type: Application
    Filed: November 3, 2004
    Publication date: October 20, 2005
    Applicant: METABOLEX, INC.
    Inventors: Jeffrey Johnson, Yun-Ping Zhou, Kimberly Marlen
  • Alpha(trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents
    Publication number: 20050222213
    Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
    Type: Application
    Filed: February 17, 2005
    Publication date: October 6, 2005
    Applicant: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Liang
  • Methods and reagents for diagnosis and treatment of diabetes
    Publication number: 20050208516
    Abstract: The invention relates to methods and reagents for diagnosing and treating diabetes.
    Type: Application
    Filed: November 3, 2004
    Publication date: September 22, 2005
    Applicant: Metabolex, Inc.
    Inventors: John Palma, Jeffrey Johnson, John Blume, Anthony Schweitzer, Phets Nhonthachit
  • Compositions and methods of using hexokinase V
    Publication number: 20050186582
    Abstract: The current invention provides methods of identifying modulators of hexokinase V. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of hexokinase V nucleic acids and proteins.
    Type: Application
    Filed: March 19, 2004
    Publication date: August 25, 2005
    Applicant: METABOLEX, INC.
    Inventors: Jeffrey Johnson, Francine Gregoire, Anthony Schweitzer, Yuko Terasawa, Maria Wilson, John Blume
  • Use of (-)(3-trihalomethylphenoxy)(4-halophenyl) acetic acid derivatives for treatment of insulin resistance, Type 2 diabetes and hyperlipidemia
    Publication number: 20050075396
    Abstract: The present invention provides the use of (?) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes and hyperlipidemia.
    Type: Application
    Filed: September 10, 2003
    Publication date: April 7, 2005
    Applicants: Metabolex, Inc., DiaTex, Inc.
    Inventors: Kenneth Luskey, Jian Luo