Patents Assigned to Metabolic Explorer
  • Patent number: 10889840
    Abstract: The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: January 12, 2021
    Assignee: METABOLIC EXPLORER
    Inventors: Laetitia Faure, Gwenaëlle Corre, Céline Raynaud, Laurence Dumon-Seignovert
  • Patent number: 10858675
    Abstract: The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized production of 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: December 8, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Wanda Dischert, Laurence Dumon-Seignovert, Perrine Vasseur, Gwénaëlle Bestel-Corre, Philippe Soucaille
  • Publication number: 20200370072
    Abstract: The present invention concerns a new method for the production of 1,3-propanediol comprising culturing a recombinant microorganism converting glycerol into 1,3-propanediol and overexpressing the hcpR and/or frdX gene on a medium comprising glycerine. A recombinant microorganism for the production of 1,3 propanediol from glycerol, wherein said microorganism converts glycerol into 1,3-propanediol and 10 overexpresses the hcpR and/or the frdX gene.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 26, 2020
    Applicant: METABOLIC EXPLORER
    Inventors: Céline RAYNAUD, Olivier TOURRASSE, Nadège DUMOULIN
  • Patent number: 10801050
    Abstract: The present invention relates to a genetically modified microorganism for the fermentative conversion of levulinic acid into propionyl-CoA and acetyl-CoA, and to a fermentation process for performing said conversion.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: October 13, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Gwenaëlle Corre, Laurence Dumon-Seignovert, Philippe Soucaille
  • Patent number: 10774320
    Abstract: The present invention relates to methods and recombinant microorganisms useful for the production of glycolic acid and/or glyoxylic acid. The methods of the invention involve either only one step of fermentation of the modified microorganisms of the invention or one step of fermentation of the modified microorganisms of the invention and one step of either biological or chemical conversion of the glycolic acid or of the glyoxylic acid, the microorganism of the invention over expressing a phosphoketolase gene.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: September 15, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Wanda Dischert, Gwenaëlle Corre, Philippe Soucaille
  • Patent number: 10731137
    Abstract: The present invention relates to new lactaldehyde reductase (LAR) enzymes useful for the production of 1,2-propanediol and to microorganisms overexpressing said enzymes. The invention also relates to a method for producing 1,2-propanediol by converting lactaldehyde into 1,2-propanediol with said enzymes.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: August 4, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Gwénaëlle Corre, Pascale Aliprandi
  • Publication number: 20200231995
    Abstract: The invention relates to a method for producing salts of butyric acid, lactic acid, propionic acid, valeric acid, acetic acid, glycolic acid, sorbic acid, fumaric acid, formic acid, malic acid, tartaric acid, citric acid, derivatives of said organic acids and mixtures thereof, comprising at least the successive steps of: ?i) culturing a microorganism in an appropriate culture medium comprising a carbon source and a nitrogen source, during a sufficient time to obtain a fermentation broth comprising the organic acid(s); ?ii) pre-treating said fermentation broth comprising at least clarification of the fermentation broth and separation of organic acids by evaporation of the clarified fermentation broth and then condensation of the volatile fraction containing organic acids (CVAF); ?v) adding inorganic C bases to said CVAF?vii) eliminating the remaining water of the CVAF, and recovering the organic acid salts.
    Type: Application
    Filed: October 1, 2018
    Publication date: July 23, 2020
    Applicant: METABOLIC EXPLORER
    Inventors: Antoine SEVENIER, Cédric COLOMB, Benjamin MARTIN
  • Patent number: 10689671
    Abstract: The present invention relates to a recombinant microorganism useful for the production of 1,2-propanediol and process for the preparation of 1,2-propanediol. The microorganism of the invention is modified in a way that the 1,2-propanediol production is improved by enhancing NADPH dependent HAR activity.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: June 23, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Pascale Aliprandi, Emilie Navarro, Céline Raynaud, Gwénaëlle Bestel Corre, Philippe Soucaille
  • Publication number: 20200181652
    Abstract: The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.
    Type: Application
    Filed: December 29, 2017
    Publication date: June 11, 2020
    Applicant: METABOLIC EXPLORER
    Inventors: Laetitia FAURE, Gwenaëlle CORRE, Céline RAYNAUD, Laurence DUMON-SEIGNOVERT
  • Publication number: 20190367898
    Abstract: The present invention relates to methods and recombinant microorganisms useful for the production of glycolic acid and/or glyoxylic acid. The methods of the invention involve either only one step of fermentation of the modified microorganisms of the invention or one step of fermentation of the modified microorganisms of the invention and one step of either biological or chemical conversion of the glycolic acid or of the glyoxylic acid, the microorganism of the invention over expressing a phosphoketolase gene.
    Type: Application
    Filed: January 26, 2018
    Publication date: December 5, 2019
    Applicant: METABOLIC EXPLORER
    Inventors: Wanda DISCHERT, Gwenaëlle CORRE, Philippe SOUCAILLE
  • Publication number: 20190352678
    Abstract: The present invention relates to a microbial consortium, especially adapted for growth and production of 1,3-propanediol from a culture medium with high glycerinecontent and specifically with a high concentration of industrial glycerine. More particularly, this microbial consortium comprises at least one strain C. acetobutylicum and at least one strain chosen among strains of C. sporogenes and/or strains of C. sphenoides. The invention also relates to a method for the production of 1,3-propanediol by culturing this microbial consortium resulting in a co-culture of these particular different microorganisms.
    Type: Application
    Filed: February 19, 2018
    Publication date: November 21, 2019
    Applicant: METABOLIC EXPLORER
    Inventors: Olivier Tourrasse, Céline Raynaud
  • Patent number: 10415062
    Abstract: The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: September 17, 2019
    Assignee: METABOLIC EXPLORER
    Inventors: Philippe Soucaille, Gwénaëlle Bestel-Corre, Laurence Dumon-Seignovert
  • Publication number: 20190276794
    Abstract: The present invention relates to a new method for the production of a molecule of interest by conversion of a source of carbon in a fermentative process comprising culturing a microorganism genetically modified for the production of molecule of interest, wherein said microorganism comprises functional genes coding PTS carbohydrate utilization system and wherein the expression of proteins regulated the expression of phosphoenolpyruvate synthase (PPS) is down-regulated. The present invention also relates to the genetically modified microorganism used in the method of the invention.
    Type: Application
    Filed: July 6, 2017
    Publication date: September 12, 2019
    Applicant: METABOLIC EXPLORER
    Inventors: Gwénaëlle CORRE, Céline RAYNAUD
  • Patent number: 10385322
    Abstract: The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 20, 2019
    Assignee: METABOLIC EXPLORER
    Inventors: Zhen Chen, Feng Geng, An-Ping Zeng, Wanda Dischert, Philippe Soucaille
  • Publication number: 20190010521
    Abstract: The present invention concerns a new method for the production of 1,3-propanediol comprising culturing a microorganism on a culture medium with high glycerine content. The invention also concerns a new microorganism, or strain of microorganism, adapted for the production of 1,3-propanediol from medium comprising high glycerine content. The invention also concerns an “adapted microorganism” which glycerol metabolism is directed to 1,3-propanediol production, and which is allowed to grow in the presence of a high concentration of industrial glycerine. The invention also concerns a biosourced 1,3-propanediol obtained by the process thereof. Finally the invention concerns the use of the above described biosourced 1,3-propanediol as extender chain in thermoplastic polyurethane, as monomers in polytrimethylene terephtalate and as a component in cosmetics formulations.
    Type: Application
    Filed: September 13, 2018
    Publication date: January 10, 2019
    Applicant: METABOLIC EXPLORER
    Inventors: Michel CHATEAU, Jean-Yves DUBOIS, Philippe SOUCAILLE
  • Publication number: 20180312890
    Abstract: The present invention relates to a genetically modified microorganism for the fermentative conversion of levulinic acid into propionyl-CoA and acetyl-CoA, and to a fermentation process for performing said conversion.
    Type: Application
    Filed: October 23, 2015
    Publication date: November 1, 2018
    Applicant: METABOLIC EXPLORER
    Inventors: Gwenaëlle CORRE, Laurence DUMON-SEIGNOVERT, Philippe SOUCAILLE
  • Publication number: 20180282706
    Abstract: The present invention relates to new lactaldehyde reductase (LAR) enzymes useful for the production of 1,2-propane-diol and to microorganisms overexpressing said enzymes. The invention also relates to a method for producing 1,2-propanediol by converting lactaldehyde into 1,2-propanediol with said enzymes.
    Type: Application
    Filed: September 10, 2015
    Publication date: October 4, 2018
    Applicant: METABOLIC EXPLORER
    Inventors: Gwénaëlle CORRE, Pascale ALIPRANDI
  • Publication number: 20180105845
    Abstract: The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized productionof 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Application
    Filed: April 7, 2016
    Publication date: April 19, 2018
    Applicant: METABOLIC EXPLORER
    Inventors: Wanda DISCHERT, Laurence DUMON-SEIGNOVERT, Perrine VASSEUR, Gwénaëlle BESTEL-CORRE, Philippe SOUCAILLE
  • Publication number: 20180100169
    Abstract: The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Application
    Filed: April 7, 2015
    Publication date: April 12, 2018
    Applicant: METABOLIC EXPLORER
    Inventors: Philippe SOUCAILLE, Gwénaëlle BESTEL-CORRE, Laurence DUMON-SEIGNOVERT
  • Publication number: 20170240868
    Abstract: The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.
    Type: Application
    Filed: October 2, 2015
    Publication date: August 24, 2017
    Applicant: METABOLIC EXPLORER
    Inventors: Zhen CHEN, Feng GENG, An-Ping ZENG, Wanda DISCHERT, Philippe SOUCAILLE