Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.
Type:
Application
Filed:
May 18, 2011
Publication date:
January 19, 2012
Applicant:
Metabolic Solutions Development Company
Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases. Formula (I), wherein: each of R1 and R4 is independently selected from H, halo, aliphatic, and alkoxy, wherein the aliphatic and alkoxy are optionally substituted with 1-3 of halo; R2 is halo, hydroxy, or optionally substituted aliphatic, and R?2 is H, or R2 and R?2 together form oxo; R3 is H; and Ring A is a phenyl.
Type:
Grant
Filed:
September 15, 2008
Date of Patent:
November 29, 2011
Assignee:
Metabolic Solutions Development Company
Inventors:
Gerard R. Colca, Robert C. Gadwood, Tim Parker