Patents Assigned to METABOMED LTD.
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Publication number: 20230174507Abstract: The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity/weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory/autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and drug resistant cancer of various types.Type: ApplicationFiled: May 12, 2021Publication date: June 8, 2023Applicant: METABOMED LTD.Inventors: Philippe NAKACHE, Omri EREZ, Simone BOTTI, Andreas GOUTOPOULOS, Harry Finch
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Publication number: 20230084927Abstract: The present invention relates to novel compounds that modulate cellular glucose uptake by affecting various targets, including, but not limited to those related to glycolysis and known transporters/co-transporters of the GLUT family. The compounds according to the invention are useful for treating cancer such as: neuroendocrine neoplasms, gastrointestinal stromal tumors (GIST), renal cell carcinoma, paraganglioma, pheochromocytoma, pituitary adenoma, colorectal cancer, lung cancer, gastric cancer, pancreatic cancer sarcoma, head and neck cancer, melanoma, ovarian cancer and other cancers that rely on high levels of glycolysis for survival and proliferation; as well as in treating of autoimmune diseases, inflammation, infectious diseases, and metabolic diseases.Type: ApplicationFiled: November 11, 2020Publication date: March 16, 2023Applicant: METABOMED LTD.Inventors: Philippe NAKACHE, Omri EREZ, Simone BOTTI, Andreas GOUTOPOULOS
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Publication number: 20230084752Abstract: The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity/weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory/autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and dmg resistant cancer of various types.Type: ApplicationFiled: May 14, 2020Publication date: March 16, 2023Applicant: Metabomed Ltd.Inventors: Philippe NAKACHE, Omri Erez, Simone BOTTI, Andreas GOUTOPOULOS, Harry Finch
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Publication number: 20220305010Abstract: The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity/weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory/autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and drug resistant cancer of various types.Type: ApplicationFiled: November 4, 2020Publication date: September 29, 2022Applicant: METABOMED LTD.Inventors: Philippe NAKACHE, Omri Erez, Simone Botti, Andreas Goutopoulos
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Patent number: 10851064Abstract: The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity/weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory/autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and drug resistant cancer of various types.Type: GrantFiled: May 14, 2019Date of Patent: December 1, 2020Assignee: METABOMED LTD.Inventors: Philippe Nakache, Omri Erez, Simone Botti, Andreas Goutopoulos
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Publication number: 20190263758Abstract: The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity/weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory/autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and drug resistant cancer of various types.Type: ApplicationFiled: May 14, 2019Publication date: August 29, 2019Applicant: METABOMED LTD.Inventors: Philippe NAKACHE, Omri EREZ, Simone BOTTI, Andreas GOUTOPOULOS