Abstract: A device and a computer-implemented method for analyzing a dataset associated with a plurality of biological objects selected from cells, cell-derived vesicles, acellular microorganisms, and/or biofunctionalized materials; the dataset including N cytometric events, each associated with a biological object, each cytometric event being defined by at least two cytometric parameters measured for the corresponding biological object so that the dataset is represented by a cloud of N points in a D-dimensional space; the device and method being configured to output at least the hierarchical structure representing the different classes of biological objects and their mutual relationships.

Abstract: A method of selecting T cells with improved anti-cancer activity, the method including: a) quantifying glucose transporter 1 (GLUT1) expression level at the cell surface of a population of T cells by using a GLUT1 ligand, b) selecting T cells having a low GLUT1 expression level, wherein the T cells having a low GLUT1 expression level have improved anti-cancer activity. Also, a population of T cells with improved anti-cancer activity for use in the treatment of cancer, to the use of a GLUT1 ligand for selecting T cells with improved anti-cancer activity, and to the use of GLUT1 as a biomarker of the anti-cancer therapeutic efficacy of T cells.

Abstract: Disclosed are methods for diagnosing CAT1-related diseases, wherein the methods include detecting CAT1 in a cell by a BLV.RBD ligand, or a variant or a fragment thereof. Also disclosed is a BLV.RBD ligand, or a variant or a fragment thereof for use in the treatment of CAT1-related diseases and/or BLV infections.

Abstract: Methods for detecting and/or measuring the level of sodium-dependent multivitamin transporter (SMVT) in a biological sample. The methods include the steps of: (a) contacting the biological sample with a PERV-B.RBD ligand, a variant and/or a fragment thereof; and, detecting and/or measuring the binding of the PERV-B.RBD ligand, variant and/or fragment thereof to SMVT.

Abstract: Disclosed is an in vitro method for assessing, evaluating, monitoring or predicting cell aging of a cell, wherein the method includes measuring the expression level of at least one cell surface nutrient transporter on the cell.

Abstract: Disclosed are methods for diagnosing pancreatic cancer, including measuring the expression level of ASCT1 and/or ASCT2 and/or XPR1. Also disclosed is a RBD ligand coupled to at least one contrast agent, that may be used as a probe for medical imaging.