Patents Assigned to Metamorphix, Inc.
  • Publication number: 20130034624
    Abstract: Methods for managing animals can involve identifying a trait by analyzing a biological sample and determining a physical characteristic of a bovine subject using imaging. A method can include obtaining a targeted trait genetic value and determining a targeted trait value for a bovine subject using imaging. A method can include obtaining genetic information determined by identifying, in a biological sample from the first bovine subject, at least one single nucleotide polymorphism (SNP). An animal can be managed based on information that has been identified and/or obtained.
    Type: Application
    Filed: January 7, 2009
    Publication date: February 7, 2013
    Applicants: CARGILL, INCORPORATED, METAMORPHIX, INC.
    Inventors: Milton Alejandro Gorocica Buenfil, Duane Theuninck, Todd Raymond Allen, Larry Langford, Sue K. Denise, David Rosenfeld, Tom Holm, Dennis Fantin
  • Patent number: 8026064
    Abstract: Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for identifying breed, or line and breed, or line composition of a bovine subject. The present invention further provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for identifying breed or breed combinations for Angus, Holstein, Limousin, Brahman, Hereford, Simmental, Gelbvieh, Charolais and Beefmaster breeds. These patterns can be utilized to manage animals in a feedlot to obtain optimum performance based on known characteristics of specific breeds and identify animals for breeding in selection programs. In another aspect, these patterns can be used to ensure labeling on breed specific branded products.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: September 27, 2011
    Assignees: Metamorphix, Inc., Cargill, Incorporated
    Inventors: Sue K. DeNise, Paul Charteris, David Rosenfeld, Tom Holm, Stephen Bates
  • Publication number: 20110212441
    Abstract: Methods, compositions, and systems are provided for managing bovine subjects in order to maximize their individual potential performance and edible meat value, and to maximize profits obtained in marketing the bovine subjects. The methods and systems draw an inference of a trait of a bovine subject by determining the nucleotide occurrence of at least one bovine SNP that is identified herein as being associated with the trait. The inference is used in methods of the present invention to establish the economic value of a bovine subject, to improve profits related to selling beef from a bovine subject; to manage bovine subjects, to sort bovine subjects; to improve the genetics of a bovine population by selecting and breeding of bovine subjects, to clone a bovine subject with a specific trait, to track meat or another commercial product of a bovine subject; and to diagnose a health condition of a bovine subject.
    Type: Application
    Filed: March 8, 2010
    Publication date: September 1, 2011
    Applicants: MetaMorphix, Inc., Cargill, Incorporated
    Inventors: Sue K. DeNise, Richard Kerr, David Rosenfeld, Tom Holm, Stephen Bates, Dennis Fantin
  • Publication number: 20110207620
    Abstract: Methods and systems are provided for managing non-beef livestock subjects in order to maximize their individual potential performance and the value of a product from the non-beef livestock subjects, and to maximize profits obtained in marketing the non-beef livestock subjects. The methods and systems draw an inference of a trait of a non-beef livestock subject by determining the nucleotide occurrence of at least one non-beef livestock SNP that is determined to be associated with the trait.
    Type: Application
    Filed: February 19, 2010
    Publication date: August 25, 2011
    Applicant: METAMORPHIX, INC.
    Inventors: SUE DENISE, DAVID ROSENFELD, RICHARD KERR, STEPHEN BATES, TOM HOLM
  • Publication number: 20100162423
    Abstract: Methods and systems are provided for managing non-beef livestock subjects in order to maximize their individual potential performance and the value of a product from the non-beef livestock subjects, and to maximize profits obtained in marketing the non-beef livestock subjects. The methods and systems draw an inference of a trait of a non-beef livestock subject by determining the nucleotide occurrence of at least one non-beef livestock SNP that is determined to be associated with the trait.
    Type: Application
    Filed: October 23, 2009
    Publication date: June 24, 2010
    Applicant: Metamorphix, Inc.
    Inventors: Sue DeNise, David Rosenfeld, Richard Kerr, Stephen Bates, Tom Holm
  • Patent number: 7709206
    Abstract: Methods, compositions, and systems are provided for managing bovine subjects in order to maximize their individual potential performance and edible meat value, and to maximize profits obtained in marketing the bovine subjects. The methods and systems draw an inference of a trait of a bovine subject by determining the nucleotide occurrence of at least one bovine SNP that is identified herein as being associated with the trait. The inference is used in methods of the present invention to establish the economic value of a bovine subject, to improve profits related to selling beef from a bovine subject; to manage bovine subjects, to sort bovine subjects; to improve the genetics of a bovine population by selecting and breeding of bovine subjects, to clone a bovine subject with a specific trait, to track meat or another commercial product of a bovine subject; and to diagnose a health condition of a bovine subject.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: May 4, 2010
    Assignees: Metamorphix, Inc., Cargill, Incorporated
    Inventors: Sue K. DeNise, Paul Charteris, David Rosenfeld, Tom Holm, Stephen Bates
  • Patent number: 7511127
    Abstract: Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for identifying breed, or line and breed, or line composition of a bovine subject. The present invention further provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for identifying breed or breed combinations for Angus, Holstein, Limousin, Brahman, Hereford, Simmental, Gelbvieh, Charolais and Beefmaster breeds. These patterns can be utilized to manage animals in a feedlot to obtain optimum performance based on known characteristics of specific breeds and identify animals for breeding in selection programs. In another aspect, these patterns can be used to ensure labeling on breed specific branded products.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: March 31, 2009
    Assignees: Cargill, Incorporated, MetaMorphix, Inc.
    Inventors: Sue K. DeNise, Paul Charteris, David Rosenfeld, Tom Holm, Stephen Bates
  • Publication number: 20070264714
    Abstract: Isolated GDF-9 regulatory sequences are disclosed, as well as methods of using the sequences to modulate tissue-specific expression of genes. The GDF-9 regulatory sequences include, for example, enhancer and promoter elements that naturally drive transcription of GDF-9 in specific tissues. The GDF-9 regulatory sequences can be derived from the untranscribed upstream (e.g., first 10 kilobases) and downstream regions, and transcribed, untranslated regions of a GDF-9 gene.
    Type: Application
    Filed: March 26, 2007
    Publication date: November 15, 2007
    Applicant: MetaMorphix, Inc.
    Inventors: Martin Matzuk, Julia Elvin
  • Patent number: 7227013
    Abstract: Isolated GDF-9 regulatory sequences are disclosed, as well as methods of using the sequences to modulate tissue-specific expression of genes. The GDF-9 regulatory sequences include, for example, enhancer and promoter elements that naturally drive transcription of GDF-9 in specific tissues. The GDF-9 regulatory sequences can be derived from the untranscribed upstream (e.g., first 10 kilobases) and downstream regions, and transcribed, untranslated regions of a GDF-9 gene.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: June 5, 2007
    Assignee: Metamorphix, Inc.
    Inventors: Martin Matthew Matzuk, Julia Andrea Elvin
  • Publication number: 20060008815
    Abstract: Methods and systems are provided for managing companion animal subjects in order to maximize their individual health and potential performance and to maximize profits obtained in breeding and marketing the companion animal subjects. The methods and systems draw an inference of a phenotype for a genetic trait of a companion animal subject by determining the nucleotide occurrence of at least one companion animal SNP that is determined to be associated with the phenotype. The methods and systems described can be utilized to identify individual animals, determine or verify parentage of a single dog from any breed if the putative parent(s) are also available for testing, and are associated with, and predictive of, canine breeds. The inference is used in some aspects to diagnose a health condition or predisposition of a companion animal subject.
    Type: Application
    Filed: October 25, 2004
    Publication date: January 12, 2006
    Applicant: Metamorphix, Inc.
    Inventors: David Rosenfeld, Richard Kerr, Michelle Hutton, Sue DeNise, Stephen Bates
  • Publication number: 20050153317
    Abstract: Methods and systems are provided for managing non-beef livestock subjects in order to maximize their individual potential performance and the value of a product from the non-beef livestock subjects, and to maximize profits obtained in marketing the non-beef livestock subjects. The methods and systems draw an inference of a trait of a non-beef livestock subject by determining the nucleotide occurrence of at least one non-beef livestock SNP that is determined to be associated with the trait.
    Type: Application
    Filed: October 22, 2004
    Publication date: July 14, 2005
    Applicant: Metamorphix, Inc.
    Inventors: Sue DeNise, David Rosenfeld, Richard Kerr, Stephen Bates, Tom Holm
  • Publication number: 20050051109
    Abstract: The present invention provides devices and methods for tracking animals. More particularly, embodiments of the present invention provide a method of tracking an animal that includes assigning an animal identification to a first animal, collecting a biological sample from the first animal and associating the first animal with each premises at which the first animal is located. The invention further provides an identification device that includes a tag portion and a sample portion. The tag portion can be configured to be attached to animal in any method known in the art. The sample portion can be detachably coupled to the tag portion and can include a biological collector that can collect a biological sample from the animal.
    Type: Application
    Filed: January 7, 2004
    Publication date: March 10, 2005
    Applicant: Metamorphix, Inc.
    Inventors: Dennis Fantin, Stephen Bates, Bridger Feuz, Sue DeNise, Tom Holm
  • Publication number: 20040146915
    Abstract: The present invention provides methods to determine gender of a canine subject, that include contacting a nucleic acid sample from the canine subject with at least one probe or primer specific for canine amelogenin, and using the binding of the at least one probe or primer to detect a difference between the canine amelogenin gene on the Y chromosome and the canine amelogenin gene on the X chromosome, thereby determining gender of the canine subject. In certain aspects, gender of the canine subject is determined by contacting the nucleic acid sample with a primer pair that generate different sized amplification products depending on whether an X chromosome or a Y chromosome copy of the canine amelogenin gene is amplified.
    Type: Application
    Filed: January 9, 2004
    Publication date: July 29, 2004
    Applicant: Metamorphix, Inc.
    Inventors: Bonita J.M. Ferrie, Eric V. Johnston, Sue DeNise
  • Patent number: 6555672
    Abstract: GDF promoters (e.g., GDF-8 promoters) are described. Also described are methods of using the GDF promoters to regulate tissue-specific gene expression, and to identify compounds which regulate GDF expression.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: April 29, 2003
    Assignee: MetaMorphix, Inc.
    Inventor: Li-fang Liang