Patents Assigned to Metanomics Health GmbH
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Patent number: 10168333Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreas cancer in a subject and, preferably for differentiating between pancreatic cancer and pancreatitis and a method for identifying whether a subject is in need for a therapy of pancreatic cancer. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: December 19, 2014Date of Patent: January 1, 2019Assignee: METANOMICS HEALTH GMBHInventors: Beate Kamlage, Regina Reszka, Erik Peter, Jürgen Kastler, Philipp Schatz, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Markus Lerch, Christian Pilarsky, Robert Grützmann
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Patent number: 10139413Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreas cancer in a subject and, preferably for differentiating between pancreatic cancer and pancreatitis and a method for identifying whether a subject is in need for a therapy of pancreatic cancer. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: December 19, 2014Date of Patent: November 27, 2018Assignee: METANOMICS HEALTH GMBHInventors: Beate Kamlage, Regina Reszka, Erik Peter, Jürgen Kastler, Philipp Schatz, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Markus Lerch, Christian Pilarsky, Robert Grützmann
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Publication number: 20180267018Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: May 18, 2018Publication date: September 20, 2018Applicants: METANOMICS HEALTH GMBH, Universitätsklinikum Schleswig-HolsteinInventors: Hennicke Kamp, Ulrike Rennefahrt, Jens Fuhrmann, Dietrich Rein, Jochen Hampe, Clemens Schafmayer
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Publication number: 20180180619Abstract: The present invention relates to a method for diagnosing pancreatic cancer in a subject comprising the steps of: (a) determining in at least one sample of said subject the amounts of a group of diagnostic biomarkers comprising (i) at least one diagnostic amino acid, said diagnostic amino acid being proline, histidine or tryptophan, preferably, being proline; (ii) at least one diagnostic ceramide, said diagnostic ceramide being ceramide (d18:1,C24:0) or ceramide (d18:2,C24:0), preferably being ceramide (d18:1,C24:0); (iii) at least one diagnostic sphingomyelin, said diagnostic sphingomyelin being sphingomyelin (35:1), sphingomyelin (d17:1,C16:0), sphingomyelin (41:2) or sphingomyelin (d18:2,C17:0), preferably being sphingomyelin (35:1); and (iv) CA19-9; and (b) comparing said amounts of the diagnostic biomarkers with a reference, whereby pancreatic cancer is diagnosed.Type: ApplicationFiled: June 24, 2016Publication date: June 28, 2018Applicant: METANOMICS HEALTH GMBHInventors: Beate Kamlage, Regina Reszka, Philip Schatz, Martin Dostler, Susan Carvalho, Erik Peter, Philipp Mappes, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Marcus Lerch, Robert Gruetzmann, Christian Pilarsky
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Patent number: 10001468Abstract: The present invention provides biomarkers and a method for differentiating between NASH and NAFLD in a subject.Type: GrantFiled: August 18, 2015Date of Patent: June 19, 2018Assignees: METANOMICS HEALTH GMBH, UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEINInventors: Hennicke Kamp, Ulrike Rennefahrt, Jens Fuhrmann, Dietrich Rein, Jochen Hampe, Clemens Schafmayer
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Publication number: 20160003799Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention relates to a method for assessing the quality of a biological sample comprising the steps of determining in a sample the amount of at least one biomarker from Tables 1, 1?, 2, 2?, 3, 3?, 4, 5, 5?, 6, 7, and/or 8 and comparing the said amount of the at least one biomarker with a reference, whereby the quality of the sample is assessed. The invention also relates to tools for carrying out the aforementioned method, such as devices and kits.Type: ApplicationFiled: February 14, 2014Publication date: January 7, 2016Applicant: Metanomics Health GMBHInventors: Beate Kamlage, Oliver Schmitz, Jürgen Kastler, Gareth Catchpole, Martin Dostler, Volker Liebenberg
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Publication number: 20150355197Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: August 18, 2015Publication date: December 10, 2015Applicants: Universitätsklinikum Schleswig-Holstein, METANOMICS HEALTH GMBHInventors: Hennicke Kamp, Ulrike Rennefahrt, Jens Fuhrmann, Dietrich Rein, Jochen Hampe, Clemens Schafmayer
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Patent number: 9140686Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: June 10, 2011Date of Patent: September 22, 2015Assignees: Metanomics Health GmbH, Universitätsklinikum Schleswig-HolsteinInventors: Hennicke Kamp, Ulrike Rennefahrt, Jens Fuhrmann, Dietrich Rein, Jochen Hampe, Clemens Schafmayer
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Publication number: 20150241406Abstract: The present invention concerns means and methods for cancer diagnosis and, in particular, diagnosis of prostate cancer. Specifically, it relates to a method for diagnosing whether a subject is at risk for recunent prostate carcinoma after prostatectomy comprising determining the amount of at least one metabolite selected from Table 2 in a test sample of a subject after prostatectomy, and comparing the determined amount to a reference, whereby it is diagnosed whether the subject is at risk for recurrent prostate carcinoma after prostatectomy. Further methods provided in accordance with the present invention relate to differentiating between a malignant prostate carcinoma tissue and a non-malignant tissue and diagnosing metastasizing prostate carcinoma in a subject. Also provided are devices for carrying out the aforementioned methods.Type: ApplicationFiled: October 2, 2013Publication date: August 27, 2015Applicants: Charité Universitätsmedizin Berlin, Metanomics Health GmbHInventors: Regina Reszka, Beate Kamlage, Bianca Bethan, Klaus Jung, Michael Lein, Glen Kristiansen, Carsten Stephan
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Publication number: 20150204851Abstract: The present invention relates to screening methods for diabetes drugs. In particular, the invention concerns a method for identifying a drug against diabetes comprising determining the amount of glyoxylate in a test sample of a subject suffering from diabetes or a diabetes-like condition, wherein said test sample has been taken after the subject has been brought into contact with a compound suspected to be a drug against diabetes and comparing the determined amount to a reference amount for glyoxylate, whereby a compound being a drug against diabetes is identified.Type: ApplicationFiled: June 27, 2013Publication date: July 23, 2015Applicant: Metanomics Health GmbHInventors: Dietrich Rein, Victoria Nikiforova, Inken Padberg, Volker Liebenberg
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Publication number: 20140323352Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: November 29, 2012Publication date: October 30, 2014Applicant: METANOMICS HEALTH GMBHInventors: Regina Reszka, Beate Kamlage, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Markus M. Lerch, Christian Pilarsky, Robert Grützmann
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Publication number: 20140178358Abstract: The present invention concerns means and methods for predicting the risk of a subject to suffer from liver damage. In particular, it pertains to a method for predicting the risk of a subject to suffer from liver damage caused by acetaminophen comprising determining the amount of putrescine in a blood, serum or plasma sample that has been obtained from the subject after administration of acetaminophen, and comparing the determined amount to a reference, whereby the risk of the subject to suffer from liver damage caused by acetaminophen is predicted. Also provided are devices for carrying out the aforementioned methods.Type: ApplicationFiled: December 20, 2013Publication date: June 26, 2014Applicants: The United States of America as represented by the Secretary of Department of Health and Human Servi, Metanomics Health GmbHInventors: Alexander Strigun, Lisette Leonhardt, Dörthe Ahlbory-Dieker, Lisa M. Pence, Richard Beger
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Publication number: 20130295692Abstract: A method for diagnosing diabetes or a predisposition for diabetes is provided, which comprises determining the amount of glyoxylate in a test sample of a subject suspected to suffer from diabetes or to have a predisposition for diabetes and comparing said amount to a references, whereby diabetes or a predisposition for diabetes is to be diagnosed. Further, the use of glyoxylate or a detection agent for glyoxylate for diagnosing diabetes or a predisposition for diabetes is provided. Moreover, a device and a kit for diagnosing diabetes or a predisposition for diabetes are also provided.Type: ApplicationFiled: December 23, 2011Publication date: November 7, 2013Applicant: METANOMICS HEALTH GMBHInventors: Jan C. Wiemer, Dietrich Rein, Inken Padberg, Oliver Schmitz, Volker Liebenberg, Victoria Nikiforova
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Publication number: 20130126722Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing a liver disease in a subject and a method of differentiating between NASH and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: June 10, 2011Publication date: May 23, 2013Applicant: Metanomics Health GmbHInventors: Hennicke Kamp, Ulrike Rennefahrt, Jens Fuhrmann, Dietrich Rein, Jochen Hampe, Clemens Schafmayer
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Publication number: 20120238028Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing multiple sclerosis in a subject, a method for identifying whether a subject is in need for a therapy of multiple sclerosis or a method for determining whether a multiple sclerosis therapy is successful. Moreover, contributed is a method for diagnosing or predicting the risk of an active status of multiple sclerosis in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: November 30, 2010Publication date: September 20, 2012Applicant: Metanomics Health GmbHInventors: Regina Reszka, Ulrike Rennefahrt, Andreas Hewelt, Jürgen Kastler, Jens Fuhrmann, Frauke Zipp, Carmen Infante-Duarte
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Publication number: 20120122243Abstract: The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium.Type: ApplicationFiled: June 2, 2010Publication date: May 17, 2012Applicants: CHARITE UNIVERSITATSMEDIZIN BERLIN, METANOMICS HEALTH GMBHInventors: Beate Kamlage, Bianca Bethan, Regina Reszka, Edgar Leibold, Klaus Jung, Michael Lein, Glen Kristiansen
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Publication number: 20110113863Abstract: The present invention relates to the field of diagnostic measures. Specifically, it contemplates a method for assessing whether gastric bypass therapy was successful in a subject, a method of predicting whether gastric bypass therapy will be beneficial for a subject in need thereof, and a method of diagnosing whether a supportive therapy accompanying gastric bypass has beneficial effects on a subject in need thereof. Further provided are diagnostic methods for diabetes and body lean mass. Furthermore, the invention relates to a method for identifying a treatment against diabetes and/or obesity.Type: ApplicationFiled: July 15, 2009Publication date: May 19, 2011Applicants: Metanomics Health GmbH, INSERM Institute National de la Sante' et de la Recherche MedicaleInventors: Jens Fuhrmann, Dietrich Rein, Beate Kamlage, Jan C. Wiemer, Michael Manfred Herold, Karine Clément, David M. Mutch