Patents Assigned to Metaphore Pharmaceuticals, Inc.
  • Combinations of Superoxide Dismutase Mimetics and Nonsteroidal Analgesic/Anti-Inflammatory Drugs
    Publication number: 20090131377
    Abstract: Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and Nonsteroidal Analgesic/Anti-Inflammatory Drugs (NSAIDs) are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.
    Type: Application
    Filed: November 19, 2008
    Publication date: May 21, 2009
    Applicant: Metaphore Pharmaceuticals, Inc.
    Inventor: Daniela Salvemini
  • Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
    Patent number: 7407645
    Abstract: The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R?, R1, R?1, R2, R?2, R3, R?3, R4, R?4, R5, R?5, R6, R?6, R7, R?7, R8, R?8, R9, R?9, M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: August 5, 2008
    Assignee: Metaphore Pharmaceuticals, Inc.
    Inventors: William L. Neumann, Dennis P. Riley, Randy H. Weiss, Susan L. Henke, Patrick J Lennon, Karl W. Aston
  • Combinations of superoxide dismutase mimetics and opioids
    Publication number: 20040219138
    Abstract: Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and opioids are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.
    Type: Application
    Filed: December 16, 2003
    Publication date: November 4, 2004
    Applicants: MetaPhore Pharmaceuticals, Inc., Pharmacia Corporation
    Inventor: Daniela Salvemini
  • Combinations of superoxide dismutase mimetics and nonsteroidal analgesic / anti-inflammatory drugs
    Publication number: 20040147498
    Abstract: Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and Nonsteroidal Analgesic/Anti-Inflammatory Drugs (NSAIDs) are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 29, 2004
    Applicants: MetaPhore Pharmaceuticals, Inc., Pharmacia Corporation
    Inventor: Daniela Salvemini
  • Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
    Publication number: 20040131550
    Abstract: The present invention is directed to bioconjugates of complexes represented by the formula: 1
    Type: Application
    Filed: December 16, 2003
    Publication date: July 8, 2004
    Applicant: MetaPhore Pharmaceuticals, Inc.
    Inventors: William L. Neumann, Dennis P. Riley, Randy H. Weiss, Susan L. Henke, Patrick J. Lennon, Karl W. Aston
  • Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
    Publication number: 20040057904
    Abstract: The present invention is directed to bioconjugates of complexes represented by the formula: 1
    Type: Application
    Filed: April 1, 2003
    Publication date: March 25, 2004
    Applicant: MetaPhore Pharmaceuticals, Inc.
    Inventors: William L. Neumann, Dennis P. Riley, Randy H. Weiss, Susan L. Henke, Patrick J. Lennon, Karl W. Aston
  • SODm therapy for prevention and/or treatment of inflammatory disease
    Publication number: 20020128248
    Abstract: The present invention relates to pharmaceutical compositions and methods using such compositions for the treatment of inflammatory disease, specifically rheumatoid arthritis. Such compositions contain a catalyst for the dismutation of superoxide which is a low molecular weight organic ligand derived metal complexes that function as mimics of the superoxide dismutase enzyme (SOD mimetics or SODms).
    Type: Application
    Filed: November 30, 2001
    Publication date: September 12, 2002
    Applicant: MetaPhore Pharmaceuticals, Inc
    Inventor: Daniela Salvemini
  • Method of preventing and treating HIV-mediated central nervous system damage
    Publication number: 20020072512
    Abstract: The present invention relates to methods of preventing and/or treating HIV-mediated central nervous system damage. The method comprises administering to a subject therapeutic amounts of non-proteinaceous catalysts for the dismutation of superoxide to a subject either alone or in combination with a HIV anti-viral agent. The compounds of the invention are particularly suitable for treating and/or preventing AIDS Dementia Complex.
    Type: Application
    Filed: September 13, 2001
    Publication date: June 13, 2002
    Applicant: Metaphore Pharmaceuticals, Inc
    Inventor: Daniela Salvemini