Patents Assigned to Methylation Sciences International SRL
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Patent number: 9931356Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: August 23, 2016Date of Patent: April 3, 2018Assignee: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Patent number: 9925208Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: GrantFiled: February 23, 2015Date of Patent: March 27, 2018Assignee: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Dechi Guan, I. David MacDonald
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Patent number: 9801896Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: GrantFiled: October 16, 2013Date of Patent: October 31, 2017Assignee: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Dechi Guan, I. David MacDonald
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Patent number: 8975238Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: GrantFiled: April 7, 2014Date of Patent: March 10, 2015Assignee: Methylation Sciences International SRLInventors: Dechi Guan, I. David MacDonald
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Patent number: 8865203Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 5, 2012Date of Patent: October 21, 2014Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Publication number: 20140220129Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Applicant: Methylation Sciences International SRLInventors: Dechi GUAN, I. David MACDONALD
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Patent number: 8580296Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 13, 2012Date of Patent: November 12, 2013Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Patent number: 8551515Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 13, 2012Date of Patent: October 8, 2013Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Publication number: 20130149350Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: December 5, 2012Publication date: June 13, 2013Applicant: Methylation Sciences International SRLInventor: Methylation Sciences International SRL
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Publication number: 20130129792Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: December 13, 2012Publication date: May 23, 2013Applicant: METHYLATION SCIENCES INTERNATIONAL SRLInventor: METHYLATION SCIENCES INTERNATIONAL SRL
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Patent number: 8329208Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: July 28, 2010Date of Patent: December 11, 2012Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Publication number: 20110027360Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: July 28, 2010Publication date: February 3, 2011Applicant: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Publication number: 20090197824Abstract: Extended release formulations of S-methyladenosylmethionine (SAMe) are provided, as are methods of treating various disorders using extended release SAMe formulations. The extended release formulations may be used to treat a variety of disorders, including liver disorders, psychiatric disorders and joint disorders. Thus, extended release SAMe formulations may be used to treat alcoholic liver disease, fatty liver disease, hepatitis, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, and depressive disorders such as depression (e.g. major clinical depression) and dysthymia.Type: ApplicationFiled: July 17, 2008Publication date: August 6, 2009Applicant: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Joshua Freedman, Aviva Revgev, Nancy Harrison, Robert Miller, David MacDonald
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Publication number: 20090088404Abstract: Extended release formulations of S-methyladenosylmethionine (SAMe) are provided, as are methods of treating various disorders using extended release SAMe formulations. The extended release formulations may be used to treat a variety of disorders, including liver disorders, psychiatric disorders and joint disorders. Thus, extended release SAMe formulations may be used to treat alcoholic liver disease, fatty liver disease, hepatitis, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, and depressive disorders such as depression (e.g. major clinical depression) and dysthymia.Type: ApplicationFiled: July 29, 2008Publication date: April 2, 2009Applicant: Methylation Sciences International SRLInventors: Joshua Freedman, Aviva Regev, Nancy Harrison, Robert Miller, David MacDonald
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Publication number: 20080206333Abstract: Extended release formulations of S-methyladenosylmethionine (SAMe) are provided, as are methods of treating various disorders using extended release SAMe formulations. The extended release formulations may be used to treat a variety of disorders, including liver disorders, psychiatric disorders and joint disorders. Thus, extended release SAMe formulations may be used to treat alcoholic liver disease, fatty liver disease, hepatitis, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, and depressive disorders such as depression (e.g. major clinical depression) and dysthymia.Type: ApplicationFiled: January 31, 2008Publication date: August 28, 2008Applicant: METHYLATION SCIENCES INTERNATIONAL SRLInventor: Joshua Freedman