Patents Assigned to MethylGere, Inc.
  • Acyl phosphonate inhibitors of &bgr;-lactamases
    Patent number: 6599889
    Abstract: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: July 29, 2003
    Assignee: MethylGere, Inc.
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt