Patents Assigned to Metriopharm AG
  • Publication number: 20240075029
    Abstract: The present application relates to the use of a phthalazinedione in the prevention or treatment of sequelae of a SARS-CoV-2 infection. Pharmaceutical compositions, combinations, advantageous formulation techniques and a method of treatment are disclosed.
    Type: Application
    Filed: December 1, 2021
    Publication date: March 7, 2024
    Applicant: METRIOPHARM AG
    Inventors: Wolfgang BRYSCH, Astrid KAISER, Petra SCHULZ, Sara SCHUMANN, Jörg WEGERER
  • Publication number: 20230061223
    Abstract: The present invention relates to the use of 5-amino-2,3-dihydro-1,4-phthalazinedione or its pharmaceutically acceptable N salts in the inhalatory treatment of inflammatory pulmonary diseases. The invention in particular relates to the use of 5-amino-2,3-dihydro-1,4-phthalazinedione sodium salt for said purposes. Advantageous features of an aerosol containing 5-amino-2,3-dihydro-1,4-phthalazinedione or its pharmaceutically acceptable salts and a method for producing said aerosol are disclosed. The present invention further relates to a kit for inhalatory treatment of inflammatory pulmonary diseases.
    Type: Application
    Filed: January 29, 2021
    Publication date: March 2, 2023
    Applicant: MetrioPharm AG
    Inventors: Wolfgang Brysch, Astrid Kaiser, Petra Schulz, Sara Schumann, Jörg von Wegerer
  • Patent number: 11203575
    Abstract: A new method for producing a crystalline form of 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol) is provided. Advantageous uses for this crystalline form as a detecting agent or as an agent for forensic purposes are disclosed, as well a pharmaceutical composition containing said crystalline form.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: December 21, 2021
    Assignee: MetrioPharm AG
    Inventors: Thomas Martin, Josef Breu, Juliane Fleissner, Wolfgang Brysch, Jörg Von Wegerer
  • Patent number: 11111218
    Abstract: A new crystalline form of 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol) is provided. Advantageous uses for this crystalline form as a detecting agent or as an agent for forensic purposes are disclosed, as well a pharmaceutical composition containing said crystalline form.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: September 7, 2021
    Assignee: METRIOPHARM AG
    Inventors: Thomas Martin, Josef Breu, Juliane Fleissner, Wolfgang Brysch, Jörg Von Wegerer
  • Patent number: 11007192
    Abstract: The invention relates to 5-amino-2,3-dihydro-1,4-phthalazinedione or related compounds, compositions or combinations thereof, for use in the treatment of chronic progressive multiple sclerosis, in particular primary and secondary progressive multiple sclerosis. The invention in particular relates to the use of 5-amino-2,3-dihydro-1,4-phthalazinedione sodium salt for said purposes.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: May 18, 2021
    Assignee: Metriopharm AG
    Inventors: Wolfgang Brysch, Astrid Kaiser, Claudia Van Laak, Beate Ludescher, Maliha Shah, Jörg Von Wegerer
  • Publication number: 20210061771
    Abstract: The present invention relates to a method for solubilizing 5-amino-2,3-dihydro-1,4-phthalazinedione or salts thereof, to the solubilisate produced by this method and respective uses in pharmaceutical dosage forms. A phosphatidylcholine-based solubilization method is disclosed.
    Type: Application
    Filed: January 10, 2019
    Publication date: March 4, 2021
    Applicant: MetrioPharm AG
    Inventors: Ingo Saar, Wolfgang Brysch
  • Publication number: 20200369624
    Abstract: A new crystalline form of 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol) is provided. Advantageous uses for this crystalline form as a detecting agent or as an agent for forensic purposes are disclosed, as well a pharmaceutical composition containing said crystalline form.
    Type: Application
    Filed: February 15, 2017
    Publication date: November 26, 2020
    Applicant: MetrioPharm AG
    Inventors: Thomas MARTIN, Josef BREU, Juliane FLEISSNER, Wolfgang BRYSCH, Jörg von WEGERER
  • Publication number: 20200369623
    Abstract: A new method for producing a crystalline form of 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol) is provided. Advantageous uses for this crystalline form as a detecting agent or as an agent for forensic purposes are disclosed, as well a pharmaceutical composition containing said crystalline form.
    Type: Application
    Filed: February 15, 2017
    Publication date: November 26, 2020
    Applicant: MetrioPharm AG
    Inventors: Thomas MARTIN, Josef BREU, Juliane FLEISSNER, Wolfgang BRYSCH, Jörg von WEGERER
  • Patent number: 10258620
    Abstract: The invention relates to the provision of a new crystalline form for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium, the use of this form for medical purposes, methods for producing the crystalline form according to the invention, as well as pharmaceutical preparations comprising said form.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 16, 2019
    Assignee: Metriopharm AG
    Inventors: Thomas Martin, Josef Breu, Wolfgang Brysch, David Kosel, Beate Ludescher, Michael Niedermaier, Jörg Von Wegerer
  • Publication number: 20170368063
    Abstract: The invention relates to the provision of a new crystalline form for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium, the use of this form for medical purposes, methods for producing the crystalline form according to the invention, as well as pharmaceutical preparations comprising said form.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 28, 2017
    Applicant: METRIOPHARM AG
    Inventors: Thomas Martin, Josef Breu, Wolfgang Brysch, David Kosel, Beate Ludescher, Michael Niedermaier, Jörg Von Wegerer
  • Patent number: 9079863
    Abstract: The invention relates to the provision of two novel crystalline forms I and II for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt. Surprisingly, it was discovered that form I and form II have differing immunological effects. This advantageous property is useful for immunospecific applications. In addition, both forms have advantageous physicochemical properties, which are useful in the production, further processing and/or use of a pharmaceutical preparation of form I or form II or a mixture of both.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: July 14, 2015
    Assignee: MetrioPharm AG
    Inventors: Josef Breu, Wolfgang Brysch, Astrid Kaiser, Beate Ludescher, Gerrit Maass, Thomas Martin, Wolfgang Milius, Michael Niedermaier
  • Publication number: 20140303169
    Abstract: The invention relates to the provision of two novel crystalline forms I and II for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt. Surprisingly, it was discovered that form I and form II have differing immunological effects. This advantageous property is useful for immunospecific applications. In addition, both forms have advantageous physicochemical properties, which are useful in the production, further processing and/or use of a pharmaceutical preparation of form I or form II or a mixture of both.
    Type: Application
    Filed: April 8, 2014
    Publication date: October 9, 2014
    Applicant: METRIOPHARM AG
    Inventors: Josef BREU, Wolfgang BRYSCH, Astrid KAISER, Beate LUDESCHER, Gerrit MAASS, Thomas MARTIN, Wolfgang MILIUS, Michael NIEDERMAIER
  • Patent number: 8772294
    Abstract: The invention relates to the provision of two novel crystalline forms I and II for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt. Surprisingly, it was discovered that form I and form II have differing immunological effects. This advantageous property is useful for immunospecific applications. In addition, both forms have advantageous physicochemical properties, which are useful in the production, further processing and/or use of a pharmaceutical preparation of form I or form II or a mixture of both.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: July 8, 2014
    Assignee: MetrioPharm AG
    Inventors: Josef Breu, Wolfgang Brysch, Astrid Kaiser, Beate Ludescher, Gerrit Maass, Thomas Martin, Wolfgang Milius, Michael Niedermaier
  • Publication number: 20120329801
    Abstract: The invention relates to the provision of two novel crystalline forms I and II for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt. Surprisingly, it was discovered that form I and form II have differing immunological effects. This advantageous property is useful for immunospecific applications. In addition, both forms have advantageous physicochemical properties, which are useful in the production, further processing and/or use of a pharmaceutical preparation of form I or form II or a mixture of both.
    Type: Application
    Filed: March 1, 2011
    Publication date: December 27, 2012
    Applicant: Metriopharm AG
    Inventors: Josef Breu, Wolfgang Brysch, Astrid Kaiser, Beate Ludescher, Gerrit Maass, Thomas Martin, Wolfgang Milius, Michael Niedermaier