Abstract: The present invention provides compounds of formulae (I) and (II), where X in formula (I) represents a group cleavable by a nitroreductase or carboxypeptidase enzyme. Enzymatic activation of the compounds provide pharmaceutical compounds which may be used for the treatment of neoplastic disease.
Type:
Grant
Filed:
April 17, 1998
Date of Patent:
September 26, 2000
Assignee:
Mewburn Ellis
Inventors:
William Alexander Denny, Michael Patrick Hay, William Robert Wilson