Abstract: An in-vivo insertable device, which is insertable into an at least partially hollow organ of a human or animal, including a housing formed of a material and being of a contour which enable it to be inserted into an at least partially hollow organ of a human or animal, an operative portion disposed within the housing, at least one device-retaining element having three operational states: a first retracted state prior to and during insertion of the device, a second expanded state operative to retain the operative portion within the at least partially hollow organ and a third disassembled state that enables the device to be naturally evacuated from the at least partially hollow organ, the in-vivo insertable device including at least two mutually redundant, mutually diverse and mutually independently operative disassembly mechanisms which cause the at least one device-retaining element to shift to the third disassembled state.