Abstract: Apparatus (10) for the micronisation of a powdered material (P) containing particles, comprising: a container (11), containing a reserve of the powdered product (P) to be micronised; a high-energy gaseous spiral fluid-jet micronising mill (12) with which powdered product (P) is micronised; and a feed system (13) to feed powdered product (P) from container (11) to the spiral jet mill (12), wherein feed system (13) comprises a special microdispenser device (20, 21, 26, 27, 28, 29) that micrometrically dispenses and directly feeds the powdered material (P), in a dense state, to the spiral jet mill (12), and wherein said microdispenser device (20) comprises one or more dispensing sections (21) which are cyclically filled with material originating from container (11) and then emptied to feed the material to the spiral jet mill (12), opening and closing at high frequency a plurality of control valves (26, 27, 28 and 29) associated with the dispensing sections (21) of the microdispenser device (20).

Abstract: Disclosed is a process for the preparation of drug/carrier inclusion composites which involves co-grinding the mixture of drug and carrier powders in a fluid-jet mill, in particular one using air or nitrogen as the fluid, which is suitably modified to allow mechanical fusion of the powders.