Patents Assigned to Micro Sensors, Inc.
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Publication number: 20210246491Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: ApplicationFiled: April 28, 2021Publication date: August 12, 2021Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey, Michael Thomas Nguyen
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Patent number: 11021759Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: GrantFiled: April 24, 2020Date of Patent: June 1, 2021Assignee: Clinical Micro Sensors, Inc.Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey, Michael Thomas Nguyen
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Publication number: 20200332346Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: ApplicationFiled: April 24, 2020Publication date: October 22, 2020Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey
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Patent number: 10669592Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: GrantFiled: February 26, 2019Date of Patent: June 2, 2020Assignee: Clinical Micro Sensors, Inc.Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey
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Publication number: 20190185915Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: ApplicationFiled: February 26, 2019Publication date: June 20, 2019Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey
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Patent number: 10273535Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: GrantFiled: August 3, 2018Date of Patent: April 30, 2019Assignee: Clinical Micro Sensors, Inc.Inventors: Bradley Adam Brown, Milena Iacobelli Martinez, Lisa Lynn Freeman-Cook, John Jay Harvey, Christine J. Shaw, Anna Maria Al-Khouri
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Publication number: 20190062803Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: ApplicationFiled: August 3, 2018Publication date: February 28, 2019Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)Inventors: Bradley Adam Brown, Milena Iacobelli Martinez, Lisa Lynn Freeman-Cook, John Jay Harvey, Christine J. Shaw, Anna Maria Al-Khouri
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Publication number: 20190062809Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: ApplicationFiled: August 24, 2017Publication date: February 28, 2019Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)Inventors: Bradley Adam Brown, Milena Iacobelli Martinez, Lisa Lynn Freeman--Cook, John Jay Harvey, Christin J. Shaw, Anna Maria Al-Khouri
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Patent number: 10106847Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: GrantFiled: November 30, 2017Date of Patent: October 23, 2018Assignee: Clinical Micro Sensors, Inc.Inventors: Bradley Adam Brown, Milena Iacobelli Martinez, Lisa Lynn Freeman-Cook, John Jay Harvey, Christine J. Shaw, Anna Maria Al-Khouri
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Patent number: 8962151Abstract: Improved methods of bonding solid materials include a step of fabricating a micro-column array (MCA) on at least one surface to be bonded. The MCA formation process can be modified to cause and/or prevent chemical alteration of the surface being treated or to deposit a coating on the surface. In a preferred embodiment, the MCA is fabricated by laser treating the surface, such as by laser ablation.Type: GrantFiled: August 10, 2007Date of Patent: February 24, 2015Assignee: Integrated Micro Sensors, Inc.Inventors: David Starikov, Abdelhak Bensaoula
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Patent number: 8741585Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.Type: GrantFiled: January 31, 2013Date of Patent: June 3, 2014Assignee: Clinical Micro Sensors, Inc.Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
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Publication number: 20120135530Abstract: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.Type: ApplicationFiled: October 31, 2007Publication date: May 31, 2012Applicant: Clinical Micro Sensors, Inc.Inventors: Cynthia C. Bamdad, Robert C. Mucic
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Publication number: 20120132527Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.Type: ApplicationFiled: October 30, 2007Publication date: May 31, 2012Applicant: Clinical Micro Sensors, Inc.Inventor: Jon Faiz Kayyem
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Publication number: 20110180425Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: ApplicationFiled: October 31, 2007Publication date: July 28, 2011Applicant: Clinical Micro Sensors, Inc.Inventor: Jon Faiz Kayyem
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Publication number: 20100285981Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: ApplicationFiled: October 31, 2007Publication date: November 11, 2010Applicant: Clinical Micro Sensors, Inc.Inventor: Jon Faiz Kayyem
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Publication number: 20100157509Abstract: A method for storing energy in a capacitor includes connecting a first conductor to a first electrode and a second conductor to a second electrode. The second electrode is separated from the first electrode by a dielectric layer. The dielectric layer includes a layer of boron oxynitride, BON. The conductivity of the dielectric layer is lower than the conductivity of the first electrode or the second electrode. A voltage of at least 5 volts is applied between the first electrode and the second electrode by means of the first and second conductors.Type: ApplicationFiled: December 20, 2008Publication date: June 24, 2010Applicant: Integrated Micro Sensors Inc.Inventors: Nacer Badi, Abdelhak Bensaoula
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Patent number: 7566875Abstract: A photodetector having sensitivity in a wide temperature range in both an infrared and an ultraviolet band is provided. The photodetector is formed on a single chip and is designed to be blind to solar or visible radiation. Structures disclosed allow fast and efficient detection of signals with high spatial and temporal resolution. Such sensors may be used for multi-pixel focal arrays and applied for fire detection applications, various space- and military-related applications and other applications. A method for increasing rejection of visible light by the IR sensitive material is also provided.Type: GrantFiled: March 19, 2008Date of Patent: July 28, 2009Assignee: Integrated Micro Sensors Inc.Inventors: David Starikov, Abdelhak Bensaoula
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Publication number: 20090173640Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.Type: ApplicationFiled: October 30, 2007Publication date: July 9, 2009Applicant: Clinical Micro Sensors, Inc.Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
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Publication number: 20090166196Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.Type: ApplicationFiled: October 30, 2007Publication date: July 2, 2009Applicant: Clinical Micro Sensors, Inc.Inventor: Jon Faiz Kayyem
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Patent number: 7514228Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.Type: GrantFiled: August 2, 2007Date of Patent: April 7, 2009Assignee: Clinical Micro Sensors, Inc.Inventor: Thomas J. Meade