Patents Assigned to Microbial Chemistry Research Foundation
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Publication number: 20130337050Abstract: A peptide, wherein the peptide comprises an amino acid sequence expressed by the following SEQ ID NO: 1, an amino acid sequence expressed by the following SEQ ID NO: 2, an amino acid sequence expressed by the following SEQ ID NO: 3, an amino acid sequence expressed by the following SEQ ID NO: 4, or any combination thereof: (SEQ?ID?NO:?1) ALGDSLYGAASLN; (SEQ?ID?NO:?2) MTVDNPASTTNKDKLFSVWK; (SEQ?ID?NO;?3) PGAVPEK; and (SEQ?ID?NO:?4) STKDLTTY.Type: ApplicationFiled: July 31, 2013Publication date: December 19, 2013Applicants: ImmunoFuture, Inc., Microbial Chemistry Research FoundationInventors: Akio NOMOTO, Coh-ichi NIHEI
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Publication number: 20130338375Abstract: A thioamide compound represented by the following general formula (1); wherein, in the general formula (1), R1 represents one of —OR11 and —NR12R13; R2 and R3 each independently represent one of a protecting group of an amide group and a hydrogen atom; the R11 represents one of a protecting group of a hydroxyl group and a hydrogen atom; and the R12 and R13 each independently represent one of a protecting group of an amino group and a hydrogen atom, where the R12 and R13 may together form a protecting group having a cyclic structure.Type: ApplicationFiled: August 20, 2013Publication date: December 19, 2013Applicant: Microbial Chemistry Research FoundationInventors: Masakatsu SHIBASAKI, Naoya KUMAGAI
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Patent number: 8541394Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: GrantFiled: March 7, 2012Date of Patent: September 24, 2013Assignees: Meiji Seika Pharma Co., Ltd., Microbial Chemistry Research FoundationInventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Patent number: 8507453Abstract: A novel compound that has antimicrobial activity against penicillin-resistant Streptococcus pneumoniae, and an anti-penicillin resistant pneumococci agent that includes the compound as an active ingredient are provided. Thus, an anti-penicillin resistant pneumococci agent is provided that includes as an active ingredient a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof, or hydrates thereof: wherein, in the formula (I), R represents any one of a halogen atom, an azido group, Ra-Wa-, Rb-Wb-, Rc-Wc-, and RdRd?N—.Type: GrantFiled: September 23, 2011Date of Patent: August 13, 2013Assignee: Microbial Chemistry Research FoundationInventors: Toshiaki Miyake, Yoshiaki Takahashi
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Publication number: 20130196415Abstract: A microorganism belonging to the genus Bacillus, wherein the microorganism belonging to the genus Bacillus is any one of a Bacillus subtilis 104-1-3-1 strain (Accession No: NITE BP-680) and a derivative strain thereof, and wherein the microorganism belonging to the genus Bacillus produces a thrombolytic enzyme which decomposes waste.Type: ApplicationFiled: March 14, 2013Publication date: August 1, 2013Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATIONInventor: MICROBIAL CHEMISTRY RESEARCH FOUNDATION
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Patent number: 8383547Abstract: The present invention relates to provide an aflatoxin production inhibitor that inhibits aflatoxin production specifically and efficiently, is highly safe, and is practical, and an efficient production method thereof; and a method for controlling aflatoxin contamination that uses the aflatoxin production inhibitor, specifically relating to an aflatoxin production inhibitor that includes at least one of a dioctatin represented by the following formula (I) and a derivative thereof, as an active ingredient: where, in the formula (I), R represents one of hydrogen and a methyl group.Type: GrantFiled: December 19, 2011Date of Patent: February 26, 2013Assignees: Microbial Chemistry Research Foundation, The University of TokyoInventors: Shohei Sakuda, Keita Nakamura, Tetsuo Akiyama, Yoshikazu Takahashi, Yasuhiko Muraoka, Ikuko Kurata
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Patent number: 8263369Abstract: A compound having a structure expressed by the following Structural Formula (1):Type: GrantFiled: March 1, 2011Date of Patent: September 11, 2012Assignee: Microbial Chemistry Research FoundationInventors: Hiroyuki Inoue, Manabu Kawada, Daishiro Ikeda
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Publication number: 20120190746Abstract: The present invention relates to provide an aflatoxin production inhibitor that inhibits aflatoxin production specifically and efficiently, is highly safe, and is practical, and an efficient production method thereof; and a method for controlling aflatoxin contamination that uses the aflatoxin production inhibitor, specifically relating to an aflatoxin production inhibitor that includes at least one of a dioctatin represented by the following formula (I) and a derivative thereof, as an active ingredient: where, in the formula (I), R represents one of hydrogen and a methyl group.Type: ApplicationFiled: December 19, 2011Publication date: July 26, 2012Applicants: The University of Tokyo, Microbial Chemistry Research FoundationInventors: Shohei Sakuda, Keita Nakamura, Tetsuo Akiyama, Yoshikazu Takahashi, Yasuhiko Muraoka, Ikuko Kurata
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Patent number: 8148504Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: GrantFiled: June 1, 2007Date of Patent: April 3, 2012Assignees: Meiji Seika Pharma Co., Ltd., Microbial Chemistry Research FoundationInventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Publication number: 20120003717Abstract: The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to Streptomyces sp., or a strain derived therefrom, which produces a protease capable of efficiently decomposing proteins recalcitrant to proteolysis as contained in waste water, organic waste liquids, industrial wastes and so forth.Type: ApplicationFiled: August 9, 2011Publication date: January 5, 2012Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATIONInventors: Hiroyasu DOI, Naoko KINOSHITA, Tatsuzo OKA, Zhao HUI
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Patent number: 8058026Abstract: The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to Streptomyces sp., or a strain derived therefrom, which produces a protease capable of efficiently decomposing proteins recalcitrant to proteolysis as contained in waste water, organic waste liquids, industrial wastes and so forth.Type: GrantFiled: January 18, 2008Date of Patent: November 15, 2011Assignee: Microbial Chemistry Research FoundationInventors: Hiroyasu Doi, Naoko Kinoshita, Tatsuko Oka, Zhao Hui
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Patent number: 8058247Abstract: An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is a caprazamycin derivative represented, for example, by the following general formula (II): wherein Me is a methyl group; and R1 is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.Type: GrantFiled: February 11, 2009Date of Patent: November 15, 2011Assignees: Microbial Chemistry Research Foundation, Meiji Seika Kaisha, Ltd.Inventors: Yoshiaki Takahashi, Masayuki Igarashi
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Patent number: 8053418Abstract: A novel compound that has antimicrobial activity against penicillin-resistant Streptococcus pneumoniae, and an anti-penicillin resistant pneumococci agent that includes the compound as an active ingredient are provided. Thus, an anti-penicillin resistant pneumococci agent is provided that includes as an active ingredient a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof, or hydrates thereof: wherein, in the formula (I), R represents any one of a halogen atom, an azido group, Ra-Wa-, Rb-Wb-, Rc-Wc-, and RdRd?N—.Type: GrantFiled: January 24, 2006Date of Patent: November 8, 2011Assignee: Microbial Chemistry Research FoundationInventors: Toshiaki Miyake, Yoshiaki Takahashi
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Publication number: 20110213164Abstract: A compound having a structure expressed by the following Structural Formula (1):Type: ApplicationFiled: March 1, 2011Publication date: September 1, 2011Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATIONInventors: Hiroyuki Inoue, Manabu Kawada, Daishiro Ikeda
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Publication number: 20100179324Abstract: An anti-tumor agent containing, as an active ingredient, at least one of a sulphostin-related compound represented by the following General Formula (I), a pharmacologically acceptable salt thereof and a hydrate thereof; and a pharmaceutical composition containing the anti-tumor agent: where n is an integer of 1 to 3.Type: ApplicationFiled: January 11, 2010Publication date: July 15, 2010Applicants: Microbial Chemistry Research Foundation, NIPPON KAYAKU KABUSHIKI KAISHAInventors: Tetsuo AKIYAMA, Toru Masuda, Masatoshi Abe
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Publication number: 20080312080Abstract: To provide dioctatin derivatives, a production process thereof, an aflatoxin production inhibitor containing the dioctatin derivative, and a method of controlling aflatoxin contamination by use of the aflatoxin production inhibitor containing the dioctatin derivative. The present invention provides dioctatin derivatives represented by the following Structural Formula (I): where R1 and R2 each represent CH3—(CH2)n—, (CH3)2CH—CH2— or C6H5—CH2—; n represents an integer of 2 to 6; X1 and X2 each represent CH3 or hydrogen atom; and Y represents 2-amino-2-butenoic acid or amino acid residue, with compounds where R1 and R2 are each CH3(CH2)4—, X2 is a hydrogen atom and Y is 2-amino-2-butenoic acid being excluded.Type: ApplicationFiled: August 5, 2008Publication date: December 18, 2008Applicants: Microbial Chemistry Research Foundation, The University of TokyoInventors: Yasuhiko Muraoka, Shohei Sakuda
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Publication number: 20080241879Abstract: The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to Streptomyces sp., or a strain derived therefrom, which produces a protease capable of efficiently decomposing proteins recalcitrant to proteolysis as contained in waste water, organic waste liquids, industrial wastes and so forth.Type: ApplicationFiled: January 18, 2008Publication date: October 2, 2008Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATIONInventors: Hiroyasu Doi, Naoko Kinoshita, Tatsuzo Oka, Zhao Hui
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Patent number: 7344875Abstract: The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to Streptomyces sp., or a strain derived therefrom, which produces a protease capable of efficiently decomposing proteins recalcitrant to proteolysis as contained in waste water, organic waste liquids, industrial wastes and so forth.Type: GrantFiled: December 30, 2003Date of Patent: March 18, 2008Assignee: Microbial Chemistry Research FoundationInventors: Hiroyasu Doi, Naoko Kinoshita, Tatsuzo Oka, Zhao Hui
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Publication number: 20030186976Abstract: There is provided benzofuryl-&agr;-pyrone derivative represented by the following structural formula (I): 1Type: ApplicationFiled: May 12, 2003Publication date: October 2, 2003Applicant: TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATIONInventors: Yoshimitsu Naniwa, Hiroshi Imai, Tomohide Ida, Emiko Muratani, Kazuo Kitai, Yoshinori Sugimoto, Tomomi Kosugi, Akiko Takeuchi, Kunihito Watanabe, Takami Tomiyama, Tomio Takeuchi, Masa Hamada
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Patent number: 6589984Abstract: There is provided benzofuryl-&agr;-pyrone derivative represented by the following structural formula (I): wherein R1 represents a hydrogen atom or an alkyl group of 1 to 5 carbons; R2 represents hydrogen, —CO—R5 or —SO2R6; R3 represents hydrogen, an alkyl group of 1 to 5 carbons, etc.; and R4 is a substituent attached to the 4-carbon, 5-carbon, 6-carbon or 7 carbon of the benzofuran ring; and their salts. The compounds are useful as therapeutic agent for hypertriglyceridemia, lipid metabolism enhancers, or prophylactic and/or therapeutic agents for arteriosclerosis.Type: GrantFiled: September 11, 2000Date of Patent: July 8, 2003Assignees: Teijin Limited, Microbial Chemistry Research FoundationInventors: Yoshimitsu Naniwa, Hiroshi Imai, Tomohide Ida, Emiko Muratani, Kazuo Kitai, Yoshinori Sugimoto, Tomomi Kosugi, Akiko Takeuchi, Kunihito Watanabe, Takami Tomiyama, Tomio Takeuchi, Masa Hamada