Patents Assigned to Microbiological Research Authority, United Kingdom corporation
  • Encapsulation of bioactive agents
    Publication number: 20020182412
    Abstract: Bioactive agent is encapsulated in a polymer microparticle in a (water-in-oil)-in-water emulsion-based method, and using a solvent that comprises ethyl acetate. Also described are microparticles comprising low inherent viscosity (i.v.) PLG, some with i.v. less than 0.5 dl/g, and methods for their preparation. DNA release is modified through use of low i.v. PLG. A particle production method for scale-up uses a blender that avoids excessive shear damage to DNA being encapsulated.
    Type: Application
    Filed: May 29, 2002
    Publication date: December 5, 2002
    Applicant: Microbiological Research Authority, a United Kingdom corporation
    Inventors: Graham Henry Farrar, Anne Margaret Tinsley-Bown, David Hugh Jones
  • Method of making microencapsulated DNA for vaccination and gene therapy
    Publication number: 20020034551
    Abstract: A method of making a microparticle that contains DNA coding for a polypeptide is described in which a solvent extraction method is used and solvent extraction takes place at elevated temperature. Oral administration of the microparticle leads to its expression. DNA coding for an immunogen is for stimulating antibody formation in a recipient and DNA coding for a non-immunogenic polypeptide is for gene therapy applications. DNA is incorporated into the microparticle without destruction of its function.
    Type: Application
    Filed: July 3, 2001
    Publication date: March 21, 2002
    Applicant: Microbiological Research Authority, United Kingdom corporation
    Inventors: David Hugh Jones, Graham Henry Farrar, James Christopher Stephen Clegg