Patents Assigned to MicroCarb, Inc.
  • Immunogenic shiga-like toxin II variant mutants
    Patent number: 5552144
    Abstract: Disclosed herein are immunogenic mutant Shiga-Like Toxin II variants and vaccines containing such toxins. The mutant toxin comprises an SLT-IIv where the amino acid at position 167 in the A subunit has been replaced by a differently charged amino acid that essentially maintains the structure of the native A subunit. In a preferred embodiment, the glutamic acid is replaced with glutamine. An analogous modification may also be made at position 170. The vaccines are used for edema disease of swine.
    Type: Grant
    Filed: January 10, 1994
    Date of Patent: September 3, 1996
    Assignees: MicroCarb, Inc., The United States of America as represented by the Secretary of the Army
    Inventors: James E. Samuel, Valery M. Gordon
  • Monospecific polyclonal antibodies to shiga-like toxins
    Patent number: 5512282
    Abstract: Disclosed herein are high titer, monospecific, polyclonal antibodies to Shiga-like toxins. Also disclosed are methods for producing such antibodies, compositions containing them, and methods for the diagnosis, prevention, and treatment of diseases caused by Shiga-like toxins. These include hemorrhagic colitis and hemolytic uremic syndrome in humans, edema disease in swine, and calf diarrhea in cattle.
    Type: Grant
    Filed: December 28, 1993
    Date of Patent: April 30, 1996
    Assignee: MicroCarb, Inc.
    Inventors: Howard C. Krivan, James E. Samuel
  • Receptor conjugates for targeting penicillin antibiotics to bacteria
    Patent number: 5466681
    Abstract: A variety of conjugates useful for the treatment of infections due to pathogenic microorganisms are provided. The conjugates comprise at least one agent coupled to a receptor which binds a microorganism. Suitable agents include anti-infectives, such as antibiotics and synthetic drugs. The present invention also provides methods for treating infections in warm-blooded animals due to pathogenic microorganisms.
    Type: Grant
    Filed: January 12, 1994
    Date of Patent: November 14, 1995
    Assignee: MicroCarb, Inc.
    Inventors: Howard C. Krivan, A. Lennart I. Blomberg
  • Use of host cell phospholipids for inhibiting microbial colonization
    Patent number: 5411948
    Abstract: Methods for the in vitro and in vivo inhibition of microbial colonization are provided. The methods use host cell phospholipid molecules ("receptors") which bind microorganisms.
    Type: Grant
    Filed: June 16, 1993
    Date of Patent: May 2, 1995
    Assignees: HCS Research and Development, MicroCarb, Inc.
    Inventors: Clifford A. Lingwood, Howard C. Krivan, Bo Nilsson