Abstract: Methods of enhancing skin health recovery from a skin procedure comprising laser application to the skin using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid.
Abstract: Methods of accelerating or improving the healing of a skin graft or skin grafting site in a subject are provided comprising administering to the subject an amount of an inhibitor of fidgetin-like 2.
Abstract: Methods and compositions for reducing a ratio of collagen III to collagen I in wounded skin, treating wounds and accelerating healing is provided with a surfactant polymer dressing comprising FL2 siRNA, collagen and a poloxamer.
Type:
Application
Filed:
October 23, 2019
Publication date:
November 18, 2021
Applicants:
ALBERT EINSTEIN COLLEGE OF MEDICINE, MICROCURE, INC.
Inventors:
David James SHARP, Brian O'ROURKE, Adam Hildyard KRAMER
Abstract: Methods are described for enhancing the tumor homing or penetration activity of T-cells to improve cancer treatment, by exposing T-cells in vitro, ex vivo or in vivo to an agent that inhibits fidgetin-like 2 activity, such as by using an RNA interference agent.
Abstract: Methods of enhancing skin health recovery from a skin procedure comprising laser application to the skin using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid.
Abstract: The disclosure provides methods of enhancing hair growth and hair follicle restoration using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid. Specifically, the disclosure provides compositions comprising siRNA or shRNA against a human Fidgetin like-2 nucleic acid, and the methods of using the compositions. Further disclosed are siRNA sequences against a human Fidgetin like-2 nucleic acid and the formulations of the compositions.