Abstract: A dry powder inhaler device (DPI) is disclosed. When a user activates the inhaler, the DPI is capable of delivering a dry powder dose directly from a medicament container, loaded into the DPI. A method is also disclosed for delivering a dry powder medicament dose directly from a container to a user of a DPI, whereby a sealing foil of the container is being slit open concurrently with aerosolizing and entraining of the powder in the dose into the inhaled air.

Abstract: A medical product containing an accurately metered dose of a GLP-1 medicament intended for pulmonary inhalation put into a moisture-tight, high barrier seal container. The medical product optionally also contains a dose of insulin. The container is preferably adapted for application into a dry powder inhaler. The dose loaded in the container is intended for a prolonged delivery by inhalation to the deep lung where the active ingredients are absorbed into the system. Optionally the medical product also may comprise at least one biologically acceptable excipient.

Abstract: A medicament container for carrying a metered, finely divided, dry powder medication dose is disclosed. The medicament container, which is intended for administration by a dry powder inhaler device, constitutes a pod presents a bottom surface acting as a dose bed adapted for receiving a metered medication dose. The metered dose, carried by the pod, is protected from foreign matter, particularly moisture, after a sealing of the pod with a high barrier seal foil, which transforms the pod into a high barrier container. Furthermore the pod is formed such that the pod sealing foil can be slit open from a point of penetration at a first pod end to a point of exit at a second pod end by a cutter set in motion relative to the pod.

Abstract: The invention discloses a method and a tool for exact metering and volumetric filling of finely divided dry powder medicament doses into preformed containers, whereby the doses and containers are adapted for administration by inhalation using a dry powder inhaler (DPI). A filling tool illustrating the invention includes at least one receptacle (10). The shape and size of a receptacle may vary depending on the size and mass of the powder load to be metered. A stretched woven filter (106) is positioned between the second opening of the receptacle (10) and a suction nozzle (13), using flexible seals at joints to stop air and powder leakage. The shape may be circular or elliptical, the wideness and depth, i.e. the volume, is adapted to the intended load and the method of filling and unloading.

Abstract: The invention discloses a dry powder inhaler for use in a treatment of respiratory disorders.

Abstract: A medical product suitable for storing and delivering a pre-metered dose of tiotropium, devices containing the same, and methods of using the same.

Abstract: The invention discloses a medical product that may be used in a treatment of respiratory disorders.

Abstract: A therapeutic dry powder preparation and a method of administering such a preparation are disclosed for effectively de-aggregating and dispersing into air a dose of medication powder in an administration the dose to a user. The present dry powder preparation and method do not require other sources of energy besides the power of an inhalation effort by a user to produce a very high degree of de-aggregation and efficient dispersal into air of the dry powder medication dose. Utilizing an effort of sucking air through a nozzle, the particles of the therapeutic powder dose, made available to the nozzle, are gradually de-aggregated and dispersed into a stream of air entering the nozzle.

Abstract: The present invention discloses pharmaceutical dry powder combined doses for the administration by inhalation of metered dry powder combined doses of finely divided dry medication powders. Formoterol and an anticholinergic agent are selected medicaments for forming the combined doses. Metered dry powder medicinal combined doses comprising separately metered deposits of medicinally suitable quantities of each of the selected medicaments are prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined doses and the medicinal combined doses are introduced into an adapted inhaler device for a generally simultaneous or sequential delivery of the medicinal combined doses during the course of a single inhalation by a user, such that each one of the delivered medicinal combined doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments, whereby a desired therapeutic or treating effect to the user is achieved.

Abstract: An electro-dose constitutes a metered medical powder and is formed from an electro-powder constituting an active powder substance or a dry powder medical formulation being transferred onto a device member forming a dose carrier. The electro-dose prepared from an electro-powder presents a fine particle fraction (FPF) having of the order 50% or more of its content with a particle size between 0.5-5 ?m. The electro-powder of such a metered electro-dose further provides electrostatic properties regarding absolute specific charge per mass after charging of the order 0.1 to 25 ?C/g and presents a charge decay rate constant Q50 of more than 0.1 sec with a tap density of less than 0.8 g/ml and a water activity aw of less than 0.5. The electro-dose porosity is adjusted to obtain an optimized porosity value in percent of 75 to 99.9 calculated as 100?100×(Densityelectro-dose/Densityelectro-powder).

Abstract: The present invention discloses pharmaceutical dry powder combined doses for administration by inhalation of metered dry powder combined doses of finely divided dry medication doses. Formoterol and budesonide are selected medicaments for forming the combined doses. Metered dry powder medicinal combined doses comprising separately metered deposits of medicinally effective quantities of each of the selected medicaments are prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined doses and the medicinal combined doses are introduced into an adapted inhaler device for a generally simultaneous or sequential prolonged delivery of the medicinal combined doses during the course of a single inhalation by a user, such that each one of the administered medicinal combined doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments and directed to a selected location in the lungs of a user.

Abstract: A method and pharmaceutical dry powder combination of doses for the prophylaxis or treatment of a respiratory disorder in a user by inhalation of metered dry powder combinations of doses of finely divided dry medication powders. Medicaments for forming a combination of doses are selected from a group of beta2-agonists, a group of anticholinergic agents and a group of anti-inflammatory corticosteroids. Metered dry powder medicinal combinations of doses comprising separately metered deposits of medicinally suitable quantities of each of the selected medicaments are prepared. The medicinal combination of doses are introduced into an adapted inhaler device for a generally simultaneous or sequential delivery during the course of a single inhalation by a user, such that each one of the delivered medicinal combination of doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments.

Abstract: A method based on an Air-razor tool is disclosed thereby providing de-aggregation and dispersal into air of a dose of finely divided medication powder. In sucking air through a nozzle, particles of a powder dose made available to the nozzle, are gradually de-aggregated and dispersed into a stream of air entering the nozzle. The gradual de-aggregation or dispersal is produced by a relative motion introduced between the nozzle and the dose. In a preferred embodiment, the powder is deposited onto a substrate, occupying a larger area than the area of the nozzle inlet. The nozzle is preferably positioned outside the powder area, not accessing the powder in its relative motion until a created air stream entering the nozzle, exceeds a threshold flow velocity.

Abstract: The present invention discloses a method and a pharmaceutical dry powder combined dose for the prophylaxis or treatment of a respiratory disorder in a mammalian host by inhalation of a metered dry powder combined dose of finely divided dry medication powders. At least one dry powder medicament is selected from a first group of bronchodilating medicaments and at least one dry powder medicament from a second group of anti-inflammatory medicaments.

Abstract: A method as well as a therapeutic metered combined dose are disclosed for a combined administration of medicinal dry powders. A metered medicinal dry powder combined dosage comprising at least two medicaments of separate dry powder formulations is prepared, whereby the metered powder quantity per medicament is deposited in a dose forming step creating the medicinal combined dose. The deposits of the at least two medicaments are suitably kept separated from each other, such that the medicaments cannot detrimentally interact after forming of the combined dose, and the medicinal combined dose is introduced into an inhaler device for a delivery of the powder dose during the course of a single inhalation.

Abstract: A powder distribution device for transporting and mixing a fine powder with a gas is disclosed. The device presents a distribution member forming a connection between a source of fine powder and a discharge opening. The distribution member has a first inlet portion (10) and an outlet portion (12) for a stream of a first gas (1) mixed with the fine powder. The main body of the distribution member constitutes a porous body portion (16) being surrounded by a second gas (2). If a pressure gradient is created between the second gas (2) and the first gas (1), i.e. the first gas (1) being at a slightly lower pressure, the second gas (2) will leak trough the porous body (16) and thereby preventing powder, in the mix of the first gas and fine powder, from sticking or clogging within the distribution member, which thereby forms an active non-sticking wall relative to of the fine powder.

Abstract: A method and a process are disclosed for preparation of medical electro-powders. The electro-powder results from preparations of chemical and biological substances to form electro-powders suitable for electrostatic charging and dosing for functionality in a dry powder inhaler device. The electro-powder resulting from the method and process forms an active powder substance or a dry powder medical formulation with a fine particle fraction representing of the order 50% or more of the content having a size ranging between 0.5-5 &mgr;m and provides electrostatic properties with an absolute specific charge per mass after charging of the order 0.1×10−6 to 25×10−6 C/g and presenting a charge decay rate constant Q50>0.1 sec with a tap density of less than 0.8 g/ml and a water activity aw of less than 0.5.

Abstract: A method and a device for quick neutralization of a created electrostatic field formed by a multitude of basically charged particles includes a medication powder (180) deposited onto a defined target area (160) of a substrate member (140) in the course of a dose forming process. A charge generator emits charges, which are directed towards the target area of the substrate member such that the electric field created by the accumulated charges from the deposited particles is neutralized by the added charges. Various elements may be used to generate neutralizing charges, but an ion source (195) is most efficient in achieving neutralization of the dose charge and the substrate. The source may be applied so that the dose (180) and the target area (160) are exposed to the emitted charges during the entire or part of the dose forming process.

Abstract: A device is disclosed for controlling the duration of an administration of a prescribed dose of dry powder to a user's lung when inhaling the powder by use of a dry powder inhaler (DPI). The present device controls the speed of a moving cassette (4) carrying medical powder doses to one by one be administered by the DPI to a user. Generally the dose is pre-metered and applied to the cassette in the form of a strip (31) or a series of spots of ready-prepared powder. The present device using the airbrake arrangement (22) prolongs the time during which the pre-metered powder dose is released to the inhalation air. Adjustment means of the airbrake arrangement (22) define leakage of air (36) and thereby motion speed of a spring-loaded cassette (4). During the motion of the cassette the powder dose is sucked from the prepared dose powder strip onto the cassette (4) by a nozzle (1) connected to a mouthpiece used for inhaling medical powder from the dry powder inhaler.

Abstract: A foil-cutting device is disclosed for opening a foil protecting a dose of medical power carried by a dosing cassette or the like for an inhaler device. The dosing cassette will in a typical embodiment carry a number of prepared doses (31), which for protection of the medical powder are covered by a metallic or plastic foil (24). The foil-cutter device of the present invention provides a tool (11) for accessing a selected sealed dose of medical powder of the cassette during an inhalation process using a dry powder inhaler (DPI). When a user inhales through the DPI the foil-cutter opens the foil (24) for access to a pre-metered powder dose (31). The foil-cutter arrangement ensures that no access is permitted to the pre-metered dose during any other circumstances. Particularly the present invention is adapted to be applied in an inventive continuous inhaler prolonging the release of a powder dose during the inhalation of the medical powder.