Abstract: A microcytometer which combines lysing and cytometry into a unified system that achieves blood lysis and white blood cell count in a single device. The device focuses the white cells into a thin ribbon which is then focused into a single stream for analysis.
Type:
Grant
Filed:
April 3, 2002
Date of Patent:
January 6, 2004
Assignee:
Micronics, Inc.
Inventors:
Ronald Bardell, Bernhard H. Weigl, C. Frederick Battrell
Abstract: A valve for use in microfluidic structures. The valve uses a spherical member, such as a ball bearing, to depress an elastomeric member to selectively open and close a microfluidic channel. The valve may be operated manually or by use of an internal force generated to shift the spherical member to its activated position.
Abstract: A valve for use in microfluidic structures. The valve uses a spherical member, such as a ball bearing, to depress an elastomeric member to selectively open and close a microfluidic channel. The valve may be operated manually or by use of an internal force generated to shift the spherical member to its activated position.
Abstract: A capillary for introduction of whole blood into an analysis device. The capillary has a variable volume along its length, which allows the liquid sample to be drawn into the interior of the cartridge, away from the inlet, reducing the risk of contamination of the sample from the outside.
Type:
Grant
Filed:
May 23, 2001
Date of Patent:
May 6, 2003
Assignee:
Micronics, Inc.
Inventors:
Bernhard H. Weigl, Gerald L. Klein, Ronald L. Bardell, C. Frederick Battrell
Abstract: A device for analyzing sample solutions such as whole blood based on coagulation and agglutination which requires no external power source or moving parts to perform the analysis. Single disposable cartridges for performing blood typing assays can be constructed using this technology.
Type:
Grant
Filed:
March 13, 2001
Date of Patent:
December 3, 2002
Assignee:
Micronics, Inc.
Inventors:
Bernhard H. Weigl, Gerald L. Klein, Ronald L. Bardell, Clinton L. Williams, Thomas H. Schulte
Abstract: A device for promoting protein crystal growth (PCG) using microfluidic channels. A protein sample and a solvent solution are combined within a microfluidic channel having laminar flow characteristics which forms diffusion zones, providing for a well defined crystallization. Protein crystals can then be harvested from the device. The device is particularly suited for microgravity conditions.
Abstract: A device and method for performing spectral measurements in flow cells with spatial resolution using a variable transmission optical filter having at least two areas with different optical properties. Light from a light source passes through the variable transmission filter to a flow cell containing a sample to be analyzed. The resultant light pattern is sensed by a detecting means, which analyzes the spectral properties of the sample within the flow cell.
Abstract: A supervisory system in which a plurality of supervisory points (1) to (N) are monitored one after another by a monitor camera. The supervisory points are switched at random based on random numbers. A period of monitoring each supervisory point is set at random based on the random numbers. When random monitoring is carried out, it is controlled in order not to select the same supervisory point in succession.