Abstract: An endoscopic system includes a single-use portion and a multiple-use portion. The two portions can be mated and un-mated. The single-use portion includes an elongated cannula that has a bendable section near its distal end providing a “steerable” distal tip. The imaging system includes at least two separate cameras and two separate light sources. The camera and light sources are configured to simultaneously image a target object. By employing different illuminations, different filters and manipulating the spectral responses, different characteristics of the target object can be captured. According to some embodiments, a system processor can coordinate the cameras, the light sources and combine the resulting images to display to an operator an enhanced combined image the object.

Abstract: Systems and methods are configured for combined fluorescence imaging and white light imaging of tissue such as during surgical endoscopic procedures. A chip-on-tip type endoscope can be equipped with both white light and blue light LEDs. A single camera or dual cameras are configured with backside illuminated CMOS image sensor(s) to receive and process the white light and fluorescence images. The light sources, image sensors and image processing circuitry are configured to synchronously emit light and record pixels for visible white light and fluorescence frames alternately. Global or quasi-global shuttering can be used on the image sensor(s). A modified color filter array and other filters can be provided to enhance fluorescence imaging capabilities. Insufflating gas clears debris from the camera field of view and aids in moving he cannula distally through a body passageway.