Patents Assigned to MicroParts GmbH
  • Patent number: 9617064
    Abstract: A spray head for an aerosol tank, and an aerosol tank having a spray head is provided, which includes a fluid exit valve for spraying a low-solvent fluid. The fluid exit valve of the aerosol tank defines an axial fluid exit direction. The spray head includes a capillary tube for routing the fluid and for nozzle-less spraying of the fluid. An entry end of the capillary tube is axially joined to the fluid exit valve when the spray head has been seated on the aerosol tank. An exit end of the capillary tube is open to the ambient atmosphere. In the spray head, the capillary tube runs from the entry end to the exit end in an arc of approximately 90°.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: April 11, 2017
    Assignee: Boehringer Ingelheim microParts GmbH
    Inventors: Marc Rohrschneider, Waldemar Masur, Elvira Piel, Campbell Patrick, Rüdiger Belau, Karl-Heinz Lange
  • Patent number: 9610410
    Abstract: A device and a method are proposed for actuating a carpule, in which a piston is displaced in the carpule by means of a ram that is telescopically extensible by rotation, and in this way a liquid medicament formulation is expelled. For carrying out different processes, different operating movements are provided, particularly the operation of an operating element in different directions and/or the operation of different operating elements. This promotes simple, intuitive and safe operation.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: April 4, 2017
    Assignee: Boehringer Ingelheim MicroParts GmbH
    Inventors: Thorsten Joedicke, Berthold Lange, Thomas Willms, Ying Yu
  • Patent number: 9539572
    Abstract: The invention relates to an apparatus for separating blood, more particularly an apparatus (1) for absorbing blood (19) and separating blood components, e.g. blood plasma, as a sample liquid (2). Said apparatus (1) comprises a feeding device (13) for absorbing the blood (2), a device (15) for separating blood components as a sample liquid (2), a duct which preferably absorbs the sample liquid (2) exclusively by means of capillary forces, and a device for filling the duct (3) with sample liquid (2) in an inlet or feeding zone (18) of the duct (3). The separating device (15), in particular a membrane, is curved, especially convexly shaped, and the apex of said curved, especially convex shape projects into the filling device.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: January 10, 2017
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Gert Blankenstein, Holger Bartos, Ralf-Peter Peters, Christian Schoen
  • Patent number: 9522520
    Abstract: A process and a laminating device for producing a microfluidic device are proposed, wherein a film is pressed onto a carrier under the effect of heat and thereby attached to it. During the attachment the film is lifted by the blowing in of gas on the carrier side to prevent it adhering in a non-attachment region and is vented on the remote side. The device is compressed between a holder and a thermode of the laminating device during the lamination. An elastic intermediate layer is arranged in each case between the device and the holder and between the device and the thermode, for evening out the contact pressure and obtaining uniform attachment of the film to the carrier.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: December 20, 2016
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Dirk Kurowski, Oliver Paul
  • Patent number: 9409171
    Abstract: The invention relates to a microfluidic structure (1), comprising at least one cavity (10) having at least one inlet opening (11) and at least one outlet opening (12), wherein the cavity (10) can be filled with a liquid or a liquid can flow through the cavity and at least one element (13) is provided inside the cavity (10), which element stops the flow of the liquid at least temporarily and/or diverts the flow of the liquid at least in some regions within the cavity (10). According to the invention, the at least one element (13) is formed by a recess (13) introduced into a wall of the cavity (10), which recess (13) has at least one first region (14) at which the liquid stops at least temporarily and/or is diverted at least in some regions and at least one second region (15) at which the liquid preferably flows into the recess (13). Such a microfluidic structure makes it possible to fill the cavity (10) without air inclusions.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: August 9, 2016
    Assignee: Boehringer Ingelheim MicroParts GmbH
    Inventors: Dirk Kurowski, Oliver Paul
  • Patent number: 9393766
    Abstract: Process for joining a foil or a membrane. The invention relates to a method for joining at least one foil-like or membrane-like part to a structural part (9), wherein the foil-like or membrane-like part is separated by means of a tool (2) from a semi-finished product (3) and is held on the tool (2) by applying a reduced pressure, and wherein the foil-like or membrane-like part is placed on the structural part (9), and is in turn held on this (9) and joined to this (9) by applying a reduced pressure. By means of the method a precise, reliable and readily automatable joining of a foil-like or membrane-like part to a structural part (9) is possible. A device (1) is also proposed, with which the method according to the invention can readily be carried out.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: July 19, 2016
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Markus Voigt, Thomas Willms
  • Patent number: 9383293
    Abstract: The invention relates to a device for sample separation, particularly for blood separation, in which the sample liquid is introduced into a feed device. The sample flows vertically through a separating device such as a filter or a membrane, so that sample particles are retained and separated off. The sample liquid thus separated, particularly blood plasma, is received by an inlet chamber underneath the separating device and conveyed by means of a channel in the lateral direction out of the inlet chamber. Particularly advantageously, the channel extends into the inlet chamber, the channel being formed by a recess in the base of the inlet chamber.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: July 5, 2016
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Gert Blankenstein, Thanh Tu Hellmich-Duong, Dirk Kurowski, Dirk Osterloh
  • Patent number: 9364807
    Abstract: The invention relates to a component (4) of a biosensor, comprising at least one first device (6) for receiving a sample liquid, wherein the device (6) is connected via a distributor channel (7) to further receiving devices (8 to 11), into each of which a feed channel (71, 72, 73, 74) branching off from the distributor channel (7) opens, and the feed channels (71, 72, 73, 74) are arranged in succession in flow direction (S) of the sample liquid passed on through the distributor channel (7). In accordance with the invention, it is envisaged that, in the distributor channel (7), in each case between two immediately successive feed channels (71, 72; 72, 73; 73, 74) in flow direction (S), at least one region (K) for at least temporary slowing or stoppage of the capillary flow of the sample liquid has been inserted.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: June 14, 2016
    Assignee: BOEHRINGER INGELHEIM MICROPARTS GMBH
    Inventors: Christian Schoen, Michael Wagner
  • Patent number: 9333707
    Abstract: A cartridge includes a fluidically conductive floor element, a cover, and a film disposed between the elements. The cover or the floor element and the film include a filling opening for filling microfluidic channels in one of the elements having sample fluid. Pins engage in corresponding holes in the film and the associated element. By way of deforming a pin, a friction fit is produced with the wall of a hole, and a head contacting the associated substrate in a form-fitting manner is formed. A press tool is placed on a head end of a pin at a predetermined pressure, and heat transfer into the pin takes place during a weld time. The pin material is brought to above the glass transition temperature and/or the melting point, and a friction fit between the pin and the wall of the hole is formed by flowing the pin material in the hole.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: May 10, 2016
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Christian Schoen, Thorsten Joedicke, Dirk Kurowski
  • Patent number: 9289764
    Abstract: Methods and apparatus for mixing at least one sample solution with at least one reagent in at least one chamber of a microfluidic cartridge such that at least one reagent (R) is supplied to the sample solution (P) and brought into contact therewith by way of at least one movable component. In this way the loss of sample liquid or analyte can be reduced.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 22, 2016
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Berthold Lange, Christian Schoen, Tobias Eichmann
  • Patent number: 9221049
    Abstract: A device and a method for separating a supernatant of a liquid sample are proposed, in which an outlet is closed off by a water-soluble membrane that dissolves after a certain length of time so that the supernatant of the sample is automatically drained away after centrifugation. The water-soluble membrane may in principle may also be used for other purposes for temporarily retaining a liquid in a holding chamber.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: December 29, 2015
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Christian Schoen, Tanja Thiele
  • Patent number: 9220852
    Abstract: In a method of producing trench-like depressions in the surface of a wafer, particularly a silicon wafer, by plasma etching, in which the depressions are produced by alternate passivation and etching, each depression in its final geometry is provided with a protective layer of the polytetrafluoroethylene type.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: December 29, 2015
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventor: Klaus Kadel
  • Patent number: 9216413
    Abstract: The invention relates to a microfluidic apparatus for producing a volume flow that is uniform over time in a metering process. In various solution processes or reaction processes it is essential to have a specified given volume flow or mass flow of fluid available to ensure reliable dissolution of the reagent or ensure that the reaction takes place. In microfluidic apparatus in which separation of particles from a fluid, particularly blood, is carried out through a membrane, the volume flow through the membrane decreases continuously. In order to achieve a uniform volume flow during metering, it is envisaged that first of all a reservoir is filled from a first channel, so that the contents of the reservoir can then be fed to the metering process by opening a fluid stop. The emptying of the reservoir takes place with a uniform volume flow of 0.05 microliters per second to 10 microliters per second.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: December 22, 2015
    Assignee: BOEHRINGER INGELHEIM MICROPARTS GMBH
    Inventors: Gert Blankenstein, Christian Schoen
  • Patent number: 9182326
    Abstract: The invention relates to a device and a method for filtering a liquid sample, wherein first capillary-driven filtration occurs and, after initial filling, pressure-operated filtration is performed by applying a vacuum or a positive pressure.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: November 10, 2015
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Dirk Kurowski, Dirk Osterloh, Ying Yu
  • Patent number: 9116089
    Abstract: A device is proposed having a separating device for filtering a liquid sample and having a conveying device. A positive pressure or negative pressure can be generated by means of the conveying device, for accelerating or assisting the filtration.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: August 25, 2015
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Marc Grolla, Gert Blankenstein, Dirk Osterloh
  • Patent number: 9102463
    Abstract: Methods and apparatus provide for filling at least one cavity with a liquid via: partly filling a cavity of a semifinished product containing at least two cavities, covering the semifinished product at least in some areas, so as to prevent the escape of liquid from the semifinished product, displacing at least some of the liquid from the already partially filled cavity, such that at least one other cavity is completely filled by a portion of the displaced liquid and another portion of the displaced liquid at least partially fills at least one overflow.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: August 11, 2015
    Assignee: Boehringer Ingelheim MicroParts GmbH
    Inventors: Dirk Osterloh, Berthold Lange
  • Patent number: 8974751
    Abstract: Sample liquid is collected in a chamber downstream of a separating device. Adjoining the chamber are a plurality of channels which guide the sample liquid to one or more investigating regions.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: March 10, 2015
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Tobias Rodenfels, Gert Blankenstein
  • Publication number: 20150036121
    Abstract: The invention relates to a method for measuring the scattered light (L2) of particles (P, PK) in a measuring medium (F), wherein a measuring container (1) is supplied with the measuring medium (F) and incident light (L1) is shone through the measuring medium (F) at least in some regions over a certain path length (1) and in a certain direction and the light (L2) scattered from the incident light (L1) is measured within a certain angle range (?). It is provided according to the invention that the incident light (L1) is guided parallel to a longitudinal axis (S) of the measuring container (1). By these measures, known methods can be improved and it is readily possible to use the invention even for very small measuring volumes of the measuring medium (F) with the associated small dimensions of the measuring container (1).
    Type: Application
    Filed: July 2, 2012
    Publication date: February 5, 2015
    Applicant: BOEHRINGER INGELHEIM MICROPARTS GMBH
    Inventors: Dirk Kurowski, Christian Vesper, Gert Blankenstein
  • Patent number: 8916110
    Abstract: A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: December 23, 2014
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Tobias Rodenfels, Gert Blankenstein
  • Publication number: 20140227148
    Abstract: The invention relates to a microfluidic structure (1), comprising at least one cavity (10) having at least one inlet opening (11) and at least one outlet opening (12), wherein the cavity (10) can be filled with a liquid or a liquid can flow through the cavity and at least one element (13) is provided inside the cavity (10), which element stops the flow of the liquid at least temporarily and/or diverts the flow of the liquid at least in some regions within the cavity (10). According to the invention, the at least one element (13) is formed by a recess (13) introduced into a wall of the cavity (10), which recess (13) has at least one first region (14) at which the liquid stops at least temporarily and/or is diverted at least in some regions and at least one second region (15) at which the liquid preferably flows into the recess (13). Such a microfluidic structure makes it possible to fill the cavity (10) without air inclusions.
    Type: Application
    Filed: July 2, 2012
    Publication date: August 14, 2014
    Applicant: BOEHRINGER INGELHEIM MICROPARTS GMBH
    Inventors: Dirk Kurowski, Oliver Paul