Abstract: There is described a continuous process for the preparation of microscopic particles. e.g. nanoparticles or microparticles, said process comprising the steps of: (i) controlling provision of a first liquid phase to a first membrane, the first membrane defining a first plurality of apertures: (ii) controlling provision of a second liquid phase to the first membrane via the first plurality of apertures to form a mixture; and controlling provision of the mixture to a second membrane to form a stabilised suspension of particles; concentrating the suspension of particles and controlling provision of a pH buffer to a third membrane; and controlling provision of the stabilised mixture to a fourth membrane for microfiltration, to isolate the microscopic particles.

Abstract: There is described a method of preparing solid particles of a material, said method comprising controlling provision of a first liquid phase, wherein said first liquid phase comprises a solution of a first material through a membrane, said membrane defining a plurality of pores; and controlling provision of a second liquid phase, wherein said second liquid phase comprises a solution of a second material; reacting the first a second materials to produce a third liquid phase comprising a solution of a third material; and supersaturating the third liquid phase to form solid particles of the third material.

Abstract: There is described a cross-flow apparatus for producing an emulsion or dispersion by dispersing a first phase in a second phase; said cross-flow apparatus comprising: an outer tubular sleeve (2) provided with a first inlet (3) at a first end (4); an emulsion outlet (5); and a second inlet (7), distal from and inclined relative to the first inlet; a tubular membrane provided with a plurality of pores and adapted to be positioned inside the tubular sleeve (2); and optionally an insert adapted to be located inside the tubular membrane, said insert comprising an inlet end and an outlet end, each of the inlet end and an outlet end being provided with chamfered region; the chamfered region is provided with a plurality of orifices and a furcation plate.

Abstract: Membrane Emulsification Apparatus with Refiner There is described a membrane emulsification apparatus for dispersing a first phase in a second phase, comprising: •a membrane defining a plurality of apertures connecting a first volume on a first side of the membrane to a second volume on a second, different, side of the membrane, the apparatus being arranged to receive a first phase containing a liquid in the first volume and to receive a second phase in the second volume the apparatus being adapted to generate an emulsion through egression of the first phase into the second phase via the plurality of apertures; •the apparatus also comprising a refiner (1) arranged to receive the emulsion from the membrane; and wherein said refiner comprises an inlet (4/5) and an outlet (5/4) wherein an opening (8) adapted to converge flow of the emulsion and to break up droplets of the emulsion into a refined emulsion is located between the inlet and the outlet.

Abstract: There is described a method of preparing solid particles of a compound, said method comprising controlling provision of a liquid phase, wherein said liquid phase comprises a solution of the compound, in a first flow direction to a membrane, said membrane defining a plurality of pores; and controlling the supersaturation of the liquid phase after it has passed through the membrane via the plurality of pores, to form solid particles of the compound. The method may comprise a continuous method.

Abstract: There is described a method of preparing lipid vesicles, said method comprising dispersing a first liquid phase in a second liquid phase; wherein said first liquid phase comprises a lipid phase and said second liquid phase comprises an aqueous phase; or said first liquid phase comprises an aqueous phase and said second liquid phase comprises a lipid phase; said method comprising controlling provision of the first liquid phase in a first flow direction to a membrane, said membrane defining a plurality of pores; and controlling provision of the second liquid phase to the membrane in a crossflow to the first flow direction, via the plurality of pores, to form a lipid vesicle suspension.