Patents Assigned to Microscience, Ltd.
  • Genes and proteins, and their use
    Patent number: 6890539
    Abstract: A protein from Group B Streptococcus is shown to be an outer surface protein and is a useful target for antimicrobial therapy.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: May 10, 2005
    Assignee: Microscience, Ltd.
    Inventors: Martin John Glenton Hughes, Joseph David Santangelo, Jonathan Douglas Lane, Robert Feldman, Joanne Christine Moore, Richard James Dobson, Paul Everest, Gordon Dougan, Rebecca Kerry Wilson
  • Virulence genes and proteins, and their use
    Patent number: 6846667
    Abstract: The present invention is based on the identification of a series of virulence genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organisms. The identification of the genes allows them, or their expressed products, to be used in a number of ways to treat infection.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: January 25, 2005
    Assignee: Microscience, Ltd.
    Inventors: Helen Rachel Crooke, Enda Elizabeth Clarke, Paul Howard Everest, Gordon Dougan, David William Holden, Jacqueline Elizabeth Shea, Robert Graham Feldman
  • Attenuated microorganisms for the treatment of infection
    Patent number: 6756042
    Abstract: The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: June 29, 2004
    Assignee: Microscience, Ltd.
    Inventors: Robert Graham Feldman, Gordon Dougan, Joseph David Santangelo, David William Holden, Jacqueline Elizabeth Shea, Zoe Hindle