Abstract: Aggregating proteins such as IgG, are bound selectively in the presence of the non-aggregated protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed.
Type:
Grant
Filed:
July 14, 2011
Date of Patent:
February 25, 2014
Assignee:
Microsens Biphage Limited
Inventors:
Amin Reza Lane, Christopher J. Stanley, Stuart Mark Wilson