Abstract: A syringe comprising means making it possible to make the plunger (3) integral with the end (5) of the plunger stem (4) during the first filling, and to cause the disconnection between these elements during a refilling attempt.According to the invention, the connecting means between the plunger (3) and the stem (4) comprise an intermediate memorization member (6) formed such that, during filling, it ensures that these two elements (3, 4) are integral while the injection, that is to say the pressure on the plunger stem (4), causes the displacement of the intermediate member (6) relative to the two elements (3, 4) so that the latter become detached upon any second filling attempt.