Patents Assigned to Midatech Limited
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Patent number: 11179344Abstract: The present invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: at least one liver-targeting ligand, such as C2-alpha galactose; at least one payload ligand comprising a bioactive agent, such as maytansinoid DM1; and at least one dilution ligand comprising a poly(ethyleneglycol) (PEG) moiety, such as PEG COOH. Also provided are pharmaceutical compositions comprising the nanoparticle, and uses of the nanoparticle in methods of treatment of liver disorders, including liver cancers such as hepatocellular carcinoma (HCC).Type: GrantFiled: February 2, 2018Date of Patent: November 23, 2021Assignee: Midatech LimitedInventors: Tom Coulter, Philip Williams
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Patent number: 11179474Abstract: The invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: at least one liver-targeting ligand; at least one payload ligand comprising a bioactive agent; and at least one dilution ligand comprising a carbohydrate. Also provided are pharmaceutical compositions comprising the nanoparticles, medical uses thereof, including in the treatment and imaging of liver cancers, and processes for the production of the nanoparticles.Type: GrantFiled: July 25, 2016Date of Patent: November 23, 2021Assignee: MIDATECH LimitedInventors: Africa Garcia Barrientos, Esther de Torres Dominguez
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Patent number: 9474687Abstract: Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.Type: GrantFiled: October 8, 2013Date of Patent: October 25, 2016Assignees: MONOSOL RX, LLC, MIDATECH LIMITEDInventors: Phillip Williams, Thomas Rademacher, Alexander Mark Schobel, Eric Dadey
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Patent number: 9352026Abstract: The present invention relates to insulin- and insulin analog-carrying nanoparticles formulated together with or for use with free insulin or with an insulin analog, such as a rapidly-acting insulin analog. The compositions of the present invention find use in medicine, particularly in glycemic control, e.g. for controlling blood glucose levels in diabetic subjects. Nanoparticle compositions of the invention, formulated together with or for use with free insulin or with an insulin analog, comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one carbohydrate moiety; and at least one insulin peptide and/or insulin analog peptide that is non-covalently bound to the corona.Type: GrantFiled: January 29, 2015Date of Patent: May 31, 2016Assignee: Midatech LimitedInventors: Thomas Rademacher, Phillip Williams
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Patent number: 9125583Abstract: The use of nanoparticles for imaging a tumor in a mammal using electrical impedance tomography. The nanoparticles comprise a core of metal and/or semiconductor atoms to which are linked ligands that comprise a molecule capable of attaching to a specific tumor biomarker.Type: GrantFiled: November 6, 2009Date of Patent: September 8, 2015Assignees: Middlesex University Higher Education Corporation, Midatech LimitedInventors: Richard Harold Bayford, Ivan Maurice Roitt, Thomas William Rademacher, Andreas Demosthenous, Raymond Kruse Iles
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Patent number: 9114082Abstract: The present invention relates to amylin peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of blood glucose regulation. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise glutathione; and at least one amylin peptide that is non-covalently bound to the corona.Type: GrantFiled: February 6, 2014Date of Patent: August 25, 2015Assignee: Midatech LimitedInventors: Thomas Rademacher, Phillip Williams
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Patent number: 8974826Abstract: A therapeutic or bioeffecting film delivery system which includes nanoparticles having actives bound to or associated with the nanoparticles and which when administered allow the active to perform a therapeutic or bioeffecting function.Type: GrantFiled: June 10, 2011Date of Patent: March 10, 2015Assignees: Monosol RX, LLC, Midatech LimitedInventors: Alexander M. Schobel, Garry L. Myers, Keith Joseph Kendall, Thomas Rademacher, Jan Mous, Justin N. W. Barry, Phillip Williams, Africa Garcia Barrientos
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Patent number: 8895023Abstract: Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including a carbohydrate residue capable of stimulating an innate immune response, a T cell helper peptide and a danger signal. This platform may then be adapted by including one or more further ligands capable of producing a specific response to a target infectious agent.Type: GrantFiled: April 22, 2013Date of Patent: November 25, 2014Assignee: Midatech LimitedInventors: Thomas William Rademacher, Phillip Williams
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Publication number: 20140341938Abstract: The present invention provides nanoparticles and compositions comprising such nanoparticles, as well as methods for intracellular delivery of peptides, and methods of producing nanoparticles and related products. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises a peptide of choice that is covalently linked to the core via a second linker. The second linker comprises a peptide portion and a non-peptide portion, wherein said peptide portion of said second linker comprises the sequence X1X2Z1, wherein: X1 is an amino acid selected from A and G; X2 is an amino acid selected from A and G; and Z1 is an amino acid selected from Y and F.Type: ApplicationFiled: September 7, 2012Publication date: November 20, 2014Applicant: Midatech LimitedInventors: Thomas Rademacher, Phillip Williams
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Patent number: 8790934Abstract: Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.Type: GrantFiled: November 29, 2011Date of Patent: July 29, 2014Assignees: Consejo Superior de Investigaciones Cientificas, Midatech LimitedInventors: Soledad Penades, Javier Rojo, Manuel Martin-Lomas
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Patent number: 8790704Abstract: Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.Type: GrantFiled: June 8, 2012Date of Patent: July 29, 2014Assignees: Monosol RX, LLC, Midatech LimitedInventors: Phillip Williams, Thomas Rademacher, Alexander Mark Schobel, Eric Dadey
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Publication number: 20140107738Abstract: Materials and methods for making small magnetic particles, e.g., clusters of metal atoms, which can be employed as a substrate for immobilizing a plurality of ligands. Also disclosed are uses of these magnetic nanoparticles as therapeutic and diagnostic reagents, and in the study of ligand-mediated interactions.Type: ApplicationFiled: October 2, 2013Publication date: April 17, 2014Applicants: Midatech Limited, Consejo Superior De Investigacione CientificasInventors: Soledad Penades, Manual Martin-Lomas, Jesus Martines de la Fuente, Thomas William Rademacher
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Publication number: 20130337005Abstract: Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including a carbohydrate residue capable of stimulating an innate immune response, a T cell helper peptide and a danger signal. This platform may then be adapted by including one or more further ligands capable of producing a specific response to a target infectious agent.Type: ApplicationFiled: April 22, 2013Publication date: December 19, 2013Applicant: Midatech LimitedInventor: Midatech Limited
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Patent number: 8568781Abstract: Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein peptides are bound to or associated with the nanoparticles.Type: GrantFiled: June 10, 2011Date of Patent: October 29, 2013Assignee: Midatech LimitedInventors: Thomas Rademacher, Phillip Williams, Christof Bachmann, Africa Garcia Barrientos, Esther de Torres Dominguez, Javier del Campo Menoyo
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Patent number: 8557607Abstract: Materials and methods for making small magnetic particles, e.g. clusters of metal atoms, which can be employed as a substrate for immobilizing a plurality of ligands. Also disclosed are uses of these magnetic nanoparticles as therapeutic and diagnostic reagents, and in the study of ligand-mediated interactions.Type: GrantFiled: June 7, 2004Date of Patent: October 15, 2013Assignees: Consejo Superior de Investigacione Cientificas, Midatech LimitedInventors: Soledad Penades, Manuel Martin-Lomas, Jesus Martines De La Fuente, Thomas William Rademacher
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Patent number: 8425915Abstract: Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including a carbohydrate residue capable of stimulating an innate immune response, a T cell helper peptide and a danger signal. This platform may then be adapted by including one or more further ligands capable of producing a specific response to a target infectious agent.Type: GrantFiled: April 13, 2007Date of Patent: April 23, 2013Assignee: Midatech LimitedInventors: Thomas William Rademacher, Philip Williams
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Publication number: 20120071443Abstract: Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.Type: ApplicationFiled: November 29, 2011Publication date: March 22, 2012Applicant: Midatech LimitedInventors: Soledad Penades, Javier Rojo, Manuel Martin-Lomas
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Patent number: 8080431Abstract: Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.Type: GrantFiled: February 29, 2008Date of Patent: December 20, 2011Assignee: Midatech LimitedInventors: Soledad Penades, Javier Rojo, Manuel Martin-Lomas
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Publication number: 20090104268Abstract: Nanoparticles comprising adjuvants and antigens, such as tumour and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.Type: ApplicationFiled: September 30, 2005Publication date: April 23, 2009Applicant: Midatech LimitedInventors: Gottfried Himmler, G. C. Mudde, Ralf Kircheis, Thomas William Rademacher, Soledad Penades Ullate, Manuel Martin Lomas, Jose Luis De Paz Carrera, Rafael Ojeda Martinez De Castilla, Africa Garcia Barrientes
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Publication number: 20080145441Abstract: Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.Type: ApplicationFiled: February 29, 2008Publication date: June 19, 2008Applicant: MIDATECH LIMITEDInventors: Soledad Penades, Javier Rojo, Manuel Martin-Lomas