Patents Assigned to MIDATECH PHARMA (WALES) LIMITED
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Patent number: 11794158Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.Type: GrantFiled: March 17, 2021Date of Patent: October 24, 2023Assignee: MIDATECH PHARMA (WALES) LIMITEDInventors: Paul Seaman, Huw Jones, Liam McAleer
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Patent number: 11154504Abstract: A controlled release pharmaceutical formulation is provided, comprising cyclosporine-loaded microparticles of a bioresorbable polymer comprising poly(D,L-lactide), wherein the mean diameter of the microparticles is in the range 20 ?m to 40 ?m. Also provided are medical uses of the pharmaceutical formulation, in particular in the treatment of uveitis, a process for production of the pharmaceutical formulation and injectable dosage forms, including those formulated for intravitreal injection.Type: GrantFiled: December 16, 2016Date of Patent: October 26, 2021Assignee: MIDATECH PHARMA (WALES) LIMITEDInventors: Paul Seaman, Katharine Bamsey, Nigel Thomas, Dewi Paice
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Patent number: 10981131Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.Type: GrantFiled: December 16, 2016Date of Patent: April 20, 2021Assignee: MIDATECH PHARMA (WALES) LIMITEDInventors: Paul Seaman, Huw Jones, Liam McAleer
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Patent number: 9656228Abstract: A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.Type: GrantFiled: June 16, 2009Date of Patent: May 23, 2017Assignee: Midatech Pharma (Wales) LimitedInventors: Daniel Palmer, Richard Calder, Owen Shadick
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Patent number: 9625211Abstract: A device is provided for separating beads from a carrier fluid, the device comprising: a bead-receiving means for receiving beads dispersed in a carrier fluid, a fluid removal means operable to remove fluid from the bead-receiving means in a first fluid removal zone by the application of reduced pressure, and a bead collection means operable to remove beads from the bead-receiving means in a bead collection zone by the application of reduced pressure, the bead-receiving means being movable so that beads are movable from the first fluid removal zone to the bead collection zone.Type: GrantFiled: July 27, 2012Date of Patent: April 18, 2017Assignee: MIDATECH PHARMA (WALES) LIMITEDInventors: Daniel David Palmer, Owen Lesley Shadick, Stuart James Bartley, Brynmor Alexander John
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Patent number: 9156016Abstract: An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.Type: GrantFiled: September 30, 2011Date of Patent: October 13, 2015Assignee: MIDATECH PHARMA (WALES) LIMITEDInventors: Daniel Palmer, Owen Shadick