Patents Assigned to Midwest Research Institute
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Patent number: 8506686Abstract: A reel-to-reel aerosol collection and storage system for capturing and storing a plurality of separate samples of aerosol particles using electrostatic precipitation technology for collecting such particles onto a tape mechanism for analysis at a future time. The particles are collected onto a region of the collection tape for a defined period of time and then that portion of the collection tape is advanced out of the collection zone and manipulated so as to form sealed pouches or pockets which can be either severed from the collection tape for individual storage in a temperature controlled storage container, or which can be stored on a take-up reel in a temperature controlled environment. The collected aerosol particles are stored with a buffer fluid to preserve and maintain the viability of the collected particles for future extraction and analysis. Several embodiments for forming sealed pouches or pockets and methods of storing the collected particles are disclosed.Type: GrantFiled: February 2, 2011Date of Patent: August 13, 2013Assignee: Midwest Research Institute, Inc.Inventors: Joseph M. Langle, Michael F. Fischer, James M. Egan, Alexander J. Waller, Joseph W. Clement, Darren J. Radke
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Patent number: 8323386Abstract: A compact electrostatic particulate collector for sampling contaminants has a collection chamber defined by a titanium inner surface of a wall. A potential inducer is disposed within the chamber to create a field potential between itself and the wall of the chamber. A blower is disposed to propel air to be sampled through the chamber. At least one rinse channel is disposed to wet the inner surface of the wall of the chamber substantially 100%. The rinse channel is angled to direct a rinse liquid in a spiral direction around the inner surface of the wall. Contaminants in the air being sampled are electro statically biased into the rinse liquid on the wall and rinsed out of the chamber for collection.Type: GrantFiled: October 16, 2009Date of Patent: December 4, 2012Assignee: Midwest Research Institute, Inc.Inventors: Joseph Matthew Langle, Buddy Justin Winheim, Noah Boydston, Steven D. Graham, Nancy Zamora Olivares, Mark Edward Reynolds, Thomas John Breier
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Patent number: 8196479Abstract: A portable multi-tube air sampler device for capturing samples of trace elements in a suspected contaminated environment which includes a plurality of sample tubes for collecting sample trace elements, parallel inlet and outlet manifolds which minimize the length of the sample inlet path while utilizing short straight sample tubes, a hinged retainer bar mechanism which allows for easy removal and replacement of the various sample tubes, and a removably attachable controller unit which can be installed on the exterior portion of the carrying case for controlling the operation of the sampling protocol. Other embodiments include heated inlet manifold and sample intake paths to prevent contamination accumulation and carryover, a clean cycle option with a filter valved into the inlet flow path to enhance the purging cycle, and a mechanism for converting the present device to a desorbing auto sampler configuration. The present system likewise incorporates a purging cycle prior to each sampling cycle.Type: GrantFiled: October 20, 2009Date of Patent: June 12, 2012Assignee: Midwest Research Institute, Inc.Inventors: Richard K. Ludwick, Keith D. Wilson
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Patent number: 7834005Abstract: Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.Type: GrantFiled: February 13, 2009Date of Patent: November 16, 2010Assignees: The United States of America as represented by the Department of Health and Human Services, Starks Associates, Inc., Midwest Research Institute, Spirogen, Ltd.Inventors: Paul S. Liu, B. Rao Vishnuvajjala, Kenneth M. Snader, David E. Thurston, Philip W. Howard, Luke Y. Hsiao, Gregory Turner
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Patent number: 7823439Abstract: The present invention is directed to a method for multidimensional gas chromatography for separating the analytes of a complex sample. The method comprises the steps of introducing the sample onto a first column whereby the sample is separated into at least two segments, introducing at least one segment into a heartcut device whereby the segments are selectively separated into at least two heartcut fractions, introducing at least one of the fractions onto a second column whereby at least one fraction is further separated into at least two analytes, introducing at least one analyte from the second column to a gas chromatography connector, introducing the analyte from the connector to a third column, and introducing the analyte from the third column into a detector whereby the analyte is analyzed and identified.Type: GrantFiled: November 15, 2007Date of Patent: November 2, 2010Assignee: Midwest Research InstituteInventor: Chad Fisher
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Publication number: 20100167084Abstract: Methods of producing one or more biaxially textured layer on a substrate, and articles produced by the methods, are disclosed. An exemplary method may comprise electrodepositing on the substrate a precursor material selected from the group consisting of rare earths, transition metals, actinide, lanthanides, and oxides thereof. An exemplary article (150) may comprise a biaxially textured base material (130), and at least one biaxially textured layer (110) selected from the group consisting of rare earths, transition metals, actinides, lanthanides, and oxides thereof. The at least one biaxially textured layer (110) is formed by electrodeposition on the biaxially textured base material (130).Type: ApplicationFiled: August 1, 2005Publication date: July 1, 2010Applicant: Midwest Research InstituteInventors: Raghu N. Bhattacharya, Sovannary Phok, Priscila Spagnol, Tapas Chaudhuri
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Publication number: 20100143769Abstract: Provided herein are methods for manufacturing lithium-metal anode [18] assemblies for thin-film, thick-film and hulk secondary batteries that use liquid or gel-type electrolytes [14], and lithium-metal anode [18] assemblies for thick-film and bulk secondary batteries that use solid electrolytes [18]. These methods involve electrolytic formation of a lithium metal anode [18] between a protecting lithium-stable, solid electrolyte [18] material and an eieethcaiiy-Gonductive substance [20]. Secondary lithium_ batteries made by these methods aw also provided.Type: ApplicationFiled: June 11, 2007Publication date: June 10, 2010Applicant: Midwest Research InstituteInventors: Se-Hee Lee, Edwin C. Tracy, John Roland Pitts
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Publication number: 20100136715Abstract: A method for screening silicon-based wafers used in the photovoltaic industry is provided herewith.Type: ApplicationFiled: July 28, 2006Publication date: June 3, 2010Applicant: Midwest Research InstituteInventors: Bhushan L. Sopori, Peter Sheldon
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Publication number: 20090280624Abstract: Liquid-based precursors for formation of Copper Selenide, Indium Selenide, Copper Indium Diselenide, and/or copper Indium Galium Diselenide include copper-organoselenides, particulate copper selenide suspensions, copper selenide ethylene diamine in liquid solvent, nanoparticulate indium selenide suspensions, and indium selenide ethylene diamine coordination compounds in solvent. These liquid-based precursors can be deposited in liquid form onto substrates and treated by rapid thermal processing to form crystalline copper selenide and indium selenide films.Type: ApplicationFiled: November 9, 2006Publication date: November 12, 2009Applicant: Midwest Research InstituteInventors: Calvin J. Curtis, Alexander Miedaner, Marinus Franciscus Antonius van Hest, David S. Ginley
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Publication number: 20090280598Abstract: Liquid-based indium selenide and copper selenide precursors, including copper-organoselenides, particulate copper selenide suspensions, copper selenide ethylene diamine in liquid solvent, nanoparticlulate indium selenide suspensions, and indium selenide ethylene diamine coordination compounds in solvent, are used to form crystalline copper-indium-selenide, and/or copper indium galium selenide films (66) on substrates (52).Type: ApplicationFiled: November 9, 2006Publication date: November 12, 2009Applicant: Midwest Research InstituteInventors: Calvin J. Curtis, Alexander Miedaner, Maikel Van Hest, David S. Ginley, Jennifer A. Nekuda
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Publication number: 20090149449Abstract: Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.Type: ApplicationFiled: February 13, 2009Publication date: June 11, 2009Applicants: The United States of America, as represented by the Secretary, Dept. of Health and Human Service, Starks Associates, Inc., Midwest Research Institute, Spirogen, Ltd.Inventors: Paul S. Liu, B. Rao Vishnuvajjala, Kenneth M. Snader, David E. Thurston, Philip W. Howard, Luke Y. Hsiao, Gregory Turner
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Patent number: 7511032Abstract: Disclosed are compounds of Formula (I) wherein X, Y, Ri-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.Type: GrantFiled: October 22, 2004Date of Patent: March 31, 2009Assignees: The United States of America as represented by the Secretary, Department of Health and Human Services, Starks Associates, Inc., Midwest Research Institute, Spirogen, Ltd.Inventors: Paul S Liu, B. Rao Vishnuvajjala, Kenneth M Snader, David E Thurston, Philip W Howard, Luke Y Hsiao, Gregory Turner
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Publication number: 20090057137Abstract: A method (100) is provided for synthesizing a thin film electrode (350) such as an electrochromic (EC) electrode (426) or counter electrode (434) for an EC device (410), a lithiated film of transition metal oxide (616) for a battery device (600), or the like. The method (100) includes providing (140) a source material (322) within a deposition chamber (310) such as a target for sputtering, and the source material (322) includes a transition metal oxide and ionic lithium. The method (100) continues with positioning (140) an electrically conductive substrate (340) with an exposed surface within the deposition chamber (310). A thin film (350) of the transition metal oxide and the ionic lithium is deposited upon the exposed surface of the substrate (340) using physical vapor deposition with the source material (322) to form in a single deposition step a layer of lithiated transition metal oxide (350).Type: ApplicationFiled: August 20, 2008Publication date: March 5, 2009Applicant: Midwest Research InstituteInventors: J. Roland Pitts, Se-Hee Lee, C. Edwin Tracy, Dane Gillaspie
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Patent number: 7452412Abstract: A high-efficiency filter for removing or collecting trace levels of chemical compounds includes a randomly oriented glass substrate, a primer coating and a carbon coating. The present filter is operable to sample or remove chemical compounds from the air with a high volumetric capacity while maintaining a low pressure drop across the filter substrate. A method for making the present filter includes providing a glass substrate with randomly oriented glass fibers which is treated to remove any glue or other substances; the substrate is then coated with a primer including polydimethylsiloxane; and the primed substrate is then coated with a carbonaceous compound including polydimethylsiloxane.Type: GrantFiled: August 24, 2004Date of Patent: November 18, 2008Assignee: Midwest Research Institute, Inc.Inventors: Stephen B. Cummins, Gil Radolovich, Gary Cooper
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Patent number: 7419635Abstract: A sensor structure for chemochromic optical detection of hydrogen gas over a wide response range, that exhibits stability during repeated coloring/bleaching cycles upon exposure and removal of hydrogen gas, comprising: a glass substrate (20); a vanadium oxide layer (21) coated on the glass substrate; and a palladium layer (22) coated on the vanadium oxide layer.Type: GrantFiled: May 5, 2001Date of Patent: September 2, 2008Assignee: Midwest Research InstituteInventors: Ping Liu, C. Edwin Tracy, J. Roland Pitts, R. Davis Smith, II, Se-Hee Lee
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Patent number: 7420669Abstract: Described herein is an optical probe (120) for use in characterizing surface defects in wafers, such as semiconductor wafers. The optical probe (120) detects laser light reflected from the surface (124) of the wafer (106) within various ranges of angles. Characteristics of defects in the surface (124) of the wafer (106) are determined based on the amount of reflected laser light detected in each of the ranges of angles. Additionally, a wafer characterization system (100) is described that includes the described optical probe (120).Type: GrantFiled: July 1, 2004Date of Patent: September 2, 2008Assignee: Midwest Research InstituteInventors: Bhushan L. Sopori, Artak Hambarian
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Patent number: 7393673Abstract: The invention provides a thermal tolerant cellulase that is a member of the glycoside hydrolase family. The invention further discloses this cellulase as Gux1. Gux1 has been isolated and characterized from Acidothermus cellulolyticus. The invention further provides recombinant forms of the identified Gux1. Methods of making and using Gux1 polypeptides, including fusions, variants, and derivatives, are also disclosed.Type: GrantFiled: July 28, 2001Date of Patent: July 1, 2008Assignee: Midwest Research InstituteInventors: William S. Adney, Shi-You Ding, Todd B. Vinzant, Michael E. Himmel, Stephen R. Decker, Suzanne Lantz McCarter
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Patent number: 7373904Abstract: A stratified vapor generator (110) comprises a first heating section (H1) and a second heating section (H2). The first and second heating sections (H1, H2) are arranged so that the inlet of the second heating section (H2) is operatively associated with the outlet of the first heating section (H1). A moisture separator (126) having a vapor outlet (164) and a liquid outlet (144) is operatively associated with the outlet (124) of the second heating section (H2). A cooling section (C1) is operatively associated with the liquid outlet (144) of the moisture separator (126) and includes an outlet that is operatively associated with the inlet of the second heating section (H2).Type: GrantFiled: June 12, 2001Date of Patent: May 20, 2008Assignee: Midwest Research InstituteInventors: Desikan Bharathan, Vahab Hassani
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Patent number: 7374939Abstract: The present invention briefly provides a method of site-specific insertion in Zymomonas, comprising, providing a Zymomonas gene fragment, interrupting a DNA sequence the fragment, and transforming the Zymomonas through homologous recombination with the interrupted fragment.Type: GrantFiled: May 1, 2000Date of Patent: May 20, 2008Assignee: Midwest Research InstituteInventors: Min Zhang, Yat-Chen Chou
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Patent number: 7375197Abstract: The disclosure provides a method for preparing an active exoglucanase in a heterologous host of eukaryotic origin. The method includes mutagenesis to reduce glycosylation of the exoglucanase when expressed in a heterologous host. It is further disclosed a method to produce variant cellobiohydrolase that is stable at high temperature through mutagenesis.Type: GrantFiled: January 14, 2002Date of Patent: May 20, 2008Assignee: MidWest Research InstituteInventors: William S. Adney, Stephen R. Decker, Suzanne Mc Carter, John O. Baker, Raphael Nieves, Michael E. Himmel, Todd B. Vinzant