Abstract: A problem to be solved by the present invention is to provide a non-natural plant in which expression of a gene of interest is induced and a method for producing the same. Particularly, the present invention relates to a non-natural plant in which the expression of the gene is stably induced even in the absence of a physical or chemical stimulus inducing the expression of the gene, and a method for producing the same. When the induction of the expression of the gene enhances a trait of a plant of interest, the present invention provides a non-natural plant in which the trait is enhanced and a method for producing the same. To solve the problem, a non-natural regenerated plant in which the expression of the gene is induced can be produced by forming a callus from a portion of the plant of interest and then subjecting the callus to a treatment by which the expression of the gene is induced.

Abstract: Provided is a vital stain inspection method for distinguishing between cancer cells and normal cells within a lumen, or on the serous membrane side of an organ, by means of laser irradiation after organ tissue has been stained by curcumin, Red #3 or Red #106, which are edible color dyes.

Abstract: A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.

Abstract: Staphylococcus nepalensis releases corisin, a peptide conserved in diverse Staphylococci, that induces apoptosis of lung epithelial cells. Therefore, methods and apparatus for detecting the presence of corisin in a biological sample of a patient are disclosed, as well as pharmaceutical compositions, such as antibodies, and methods for treating patents having or suspected of having fibrosis.

Abstract: The disclosure provides a method for preparing exosomes using: (i) a step for ultrafiltering a sample containing at least one exosome; and (ii) a step for subjecting the sample that can be obtained from step (i) to anion exchange column chromatography.

Abstract: An optical waveguide 1, an optical waveguide 2 are formed on a substrate 3 to be crossed with each other, modulator electrodes 11, 12, 13 and 14 are arranged along the optical waveguides 1, 2, and antennas 21, 22, 23, 24 (i.e., square patch antennas having an approximately same shape) are arranged around four corners of the square shape. The modulator electrode 11 is energized from the antenna 21 and the antenna 22, the modulator electrode 12 is energized from the antenna 24 and the antenna 23, the modulator electrode 13 is energized from the antenna 21 and the antenna 24, and the modulator electrode 14 is energized from the antenna 22 and the antenna 23. The light wave propagating through the optical waveguide 1 is modulated by an electric field of Y-direction, and the light wave propagating through the optical waveguide 2 is modulated by an electric field of X-direction.

Abstract: A problem to be solved by the present invention is to provide a non-natural plant in which expression of a gene of interest is induced and a method for producing the same. Particularly, the present invention relates to a non-natural plant in which the expression of the gene is stably induced even in the absence of a physical or chemical stimulus inducing the expression of the gene, and a method for producing the same. When the induction of the expression of the gene enhances a trait of a plant of interest, the present invention provides a non-natural plant in which the trait is enhanced and a method for producing the same. To solve the problem, a non-natural regenerated plant in which the expression of the gene is induced can be produced by forming a callus from a portion of the plant of interest and then subjecting the callus to a treatment by which the expression of the gene is induced.

Abstract: It is an object to provide a novel wet wiper in which a sterilization effect and a wiping/cleaning effect are maintained even when the wet wiper is stored for a long period of time. A wet wiper is provided which includes: a fabric; and a chlorine-based treatment agent included in the fabric, wherein the chlorine-based treatment agent includes at least one of chlorous acid (HClO2), chlorite ion (ClO2?), and chlorine dioxide (ClO2) as an effective chlorine component.

Abstract: The present invention is provided with an imaging unit (10) that has an imaging head (11) to be inserted into the digestive tract (112) and images a living body by applying a laser to the digestive tract (112) via the imaging head (11); a control unit (50) for controlling the imaging head (11) to move inside the digestive tract (112); and an image processing unit (70) for processing an image captured by the imaging unit (10). The imaging unit (10) captures a plurality of imaging regions (P) to be imaged along with the movement of the imaging head (11) such that a portion of adjacent imaging regions (P1, P2) overlap, and the image processing unit (70) overlaps regions (Pa) in which the plurality of imaging regions (P1, P2) are overlapped to generate a composite image.

Abstract: The present invention is provided with an imaging unit (10) that has an imaging head (11) to be inserted into the digestive tract (112) and images a living body by applying a laser to the digestive tract (112) via the imaging head (11); a control unit (50) for controlling the imaging head (11) to move inside the digestive tract (112); and an image processing unit (70) for processing an image captured by the imaging unit (10). The imaging unit (10) captures a plurality of imaging regions (P) to be imaged along with the movement of the imaging head (11) such that a portion of adjacent imaging regions (P1, P2) overlap, and the image processing unit (70) overlaps regions (Pa) in which the plurality of imaging regions (P1, P2) are overlapped to generate a composite image.

Abstract: A chlorine neutralizer which can be used and manufactured in a simplified manner, a throw-in type chlorine neutralizer containing the same, a chlorine neutralizing apparatus, and a chlorine neutralizing method are provided. A chlorine neutralizer which neutralizes a chlorine-based component contains at least one selected from a vinyl alcohol based polymer and a polyamide resin, and the vinyl alcohol based polymer contains at least vinyl alcohol in a repeating structural unit.

Abstract: The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof.

Abstract: It is an object to provide a novel wet wiper in which a sterilization effect and a wiping/cleaning effect are maintained even when the wet wiper is stored for a long period of time. A wet wiper is provided which includes: a fabric; and a chlorine-based treatment agent included in the fabric, wherein the chlorine-based treatment agent includes at least one of chlorous acid (HClO2), chlorite ion (ClO2?), and chlorine dioxide (ClO2) as an effective chlorine component.

Abstract: The present invention relates to: a virus vector, which can effectively transfer a macromolecular antigenic peptide into target cells while maintaining a three-dimensional structure that is required for functioning as an antigen; and a vaccine utilizing the vector. Specifically, disclosed are: a virus vector, in which a nucleic acid encoding an antigenic polypeptide is integrated immediately 5? upstream of HN gene of an F gene-defective Paramyxoviridae virus gene, wherein the antigenic polypeptide is expressed as a fusion protein of 130 or more amino acid residues, fused with a TM sequence and/or a CT sequence derived from the virus.

Abstract: The present invention provides a transgenic non-human mammal retaining, in a specifically expressible state, a DNA encoding IL-33 in the skin, and having one or more features selected from the group consisting of (1) spontaneous onset of dermatitis, (2) increase in the number of inflammatory cells, (3) increase in total IgE concentration, histamine concentration, cytokine concentration and/or chemokine concentration, and (4) increase in scratching time, under SPF (specific pathogen free) breeding conditions, as compared to a corresponding non-transgenic non-human mammal, and the like.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases.

Abstract: Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.

Abstract: The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.

Abstract: A method of arranging a large number of living bodies, such as cells, embryos, or organisms rapidly, individually, and one by one, a holding sheet for the method, and a device for processing the living bodies. The method of holding living bodies includes using a sheet in which multiple through-holes with a size capable of holding one of the target living bodies, but not capable of holding two or more of the living bodies, are provided, to thereby arrange and hold the living bodies one by one in the multiple through-holes in the sheet together with a liquid.