Patents Assigned to Mie University
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Publication number: 20250109258Abstract: A resin composition including a lignin skeleton capable of producing a heat-resistant molded article and being decomposed under relatively mild conditions. The resin composition contains a lignin skeleton including, as a base component, a phenolated lignin or a derivative thereof that contains a reactive monomer group, the phenolated lignin containing a phenol-containing monomer represented by the following general formula (I): wherein R1 to R5 are each independently a monovalent group selected from H, OH, a C1 to C6 alkyl group, a C1 to C6 alkoxy group, and a C6to C10 aryl group, or adjacent substituents among R1 to R5 form a substituted or unsubstituted aromatic ring together, at least one of R1 and R2 is a hydroxyl group, and R6 is OCH3 or H; a molded article thereof, as well as a recycling method for a molded article formed in a mold formed of the resin composition.Type: ApplicationFiled: October 7, 2024Publication date: April 3, 2025Applicants: FUJI ELECTRIC CO., LTD., MIE UNIVERSITYInventors: Tomoki HASEGAWA, Masamitsu FUNAOKA
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Publication number: 20250084180Abstract: A nucleic acid molecule having a nucleotide sequence encoding a chimeric antigen receptor, where the nucleic acid molecule includes a segment encoding an extracellular domain, a segment encoding a transmembrane domain, and a segment encoding an intracellular domain. The segment encoding the extracellular domain includes a nucleotide sequence encoding an antigen binding region including a light chain variable region and a heavy chain variable region, and at least three codons in a nucleotide sequence encoding framework region 3 of the light chain variable region as defined by the Chothia method are codons encoding acidic amino acid residues.Type: ApplicationFiled: August 30, 2024Publication date: March 13, 2025Applicants: MIE UNIVERSITY, SYSMEX CORPORATIONInventors: Yasushi AKAHORI, Shingo MAETA, Atsushi FUKUNAGA, Yuriko EGASHIRA
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Publication number: 20240379906Abstract: A III nitride light-emitting device comprises: a template member having a template layer that includes compressive strain and covers the principal surface including AlXGa1-XN that has a full width at half maximum of a (10-12)-face X-ray rocking curve with 1000 arcsec or lower, where X is greater than zero and 1 or less; an active layer including a compressively strained AlGaN and generating light having a peak wavelength in deep ultraviolet wavelengths of 285 nm or below; and an n-type III nitride semiconductor region disposed on the template member. The n-type III nitride semiconductor region has an n-type first and second III nitride semiconductor layers on the template member. The n-type first III nitride semiconductor layer has a lattice relaxation rate of 2% or less relative to that of the template layer, and the n-type second III nitride semiconductor layer has a surface roughness of 0.4 nm or less.Type: ApplicationFiled: September 9, 2022Publication date: November 14, 2024Applicant: MIE UNIVERSITYInventors: Kenjiro Uesugi, Hideto Miyake, Takao Nakamura
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Patent number: 11985932Abstract: A problem to be solved by the present invention is to provide a non-natural plant in which expression of a gene of interest is induced and a method for producing the same. Particularly, the present invention relates to a non-natural plant in which the expression of the gene is stably induced even in the absence of a physical or chemical stimulus inducing the expression of the gene, and a method for producing the same. When the induction of the expression of the gene enhances a trait of a plant of interest, the present invention provides a non-natural plant in which the trait is enhanced and a method for producing the same. To solve the problem, a non-natural regenerated plant in which the expression of the gene is induced can be produced by forming a callus from a portion of the plant of interest and then subjecting the callus to a treatment by which the expression of the gene is induced.Type: GrantFiled: April 21, 2020Date of Patent: May 21, 2024Assignee: National University Corporation Mie UniversityInventor: Issei Kobayashi
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Patent number: 11952423Abstract: A novel antibody that can be used as an anti-tumor agent and an anti-tumor agent that comprises, as an active ingredient, a molecule containing such an antibody.Type: GrantFiled: May 16, 2023Date of Patent: April 9, 2024Assignees: MIE UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITEDInventors: Hiroshi Shiku, Yasushi Akahori, Kento Tanaka, Ayaka Yatsu, Junya Ichikawa, Toshiaki Ohtsuka, Shiho Kozuma, Ryuji Hashimoto, Makiko Nakayama, Naoya Shinozaki, Kensuke Nakamura, Ichiro Watanabe, Shinji Furuzono
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Patent number: 11896680Abstract: Provided is a vital stain inspection method for distinguishing between cancer cells and normal cells within a lumen, or on the serous membrane side of an organ, by means of laser irradiation after organ tissue has been stained by curcumin, Red #3 or Red #106, which are edible color dyes.Type: GrantFiled: November 27, 2018Date of Patent: February 13, 2024Assignee: MIE UniversityInventors: Akira Mizoguchi, Koji Tanaka, Kazushi Kimura, Tetsuya Nosaka, Kyosuke Tanaka, Shujie Wang, Aika Kaito, Kousyoku Sai, Yuji Toiyama, Hidemasa Goto, Masahiko Sugimoto, Yuuhei Nishimura
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Patent number: 11852632Abstract: A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.Type: GrantFiled: October 12, 2022Date of Patent: December 26, 2023Assignee: Mie UniversityInventors: Akira Mizoguchi, Koji Tanaka, Naoyuki Katayama, Tetsuya Nosaka, Kyosuke Tanaka, Shujie Wang, Aika Kaito, Kousyoku Sai, Kazushi Kimura
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Publication number: 20230404938Abstract: A method of treating a patient in need thereof includes administering a therapeutically effective amount of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEH) to serve or function as a nerve growth factor (NGF) activity promoter, preferably to treat and/or prevent a neurodegenerative disease, such as PolyQ disease, Parkinson's disease, Parkinson's syndrome, spinocerebellar degeneration, spastic paraplegia, amyotrophic lateral sclerosis, Alzheimer's disease, dementia with Lewy bodies or corticobasal degeneration.Type: ApplicationFiled: March 16, 2023Publication date: December 21, 2023Applicant: MIE UNIVERSITYInventors: Toshiyuki SHIBATA, Hideo MIYAKE, Reiji TANAKA, Fumino OKUDA, Mano HASEGAWA
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Publication number: 20230357373Abstract: Staphylococcus nepalensis releases corisin, a peptide conserved in diverse Staphylococci, that induces apoptosis of lung epithelial cells. Therefore, methods and apparatus for detecting the presence of corisin in a biological sample of a patient are disclosed, as well as pharmaceutical compositions, such as antibodies, and methods for treating patents having or suspected of having fibrosis.Type: ApplicationFiled: December 16, 2020Publication date: November 9, 2023Applicants: Mie University, The Board of Trustees of the University of IllinoisInventors: Esteban Gabazza, Corina D'Alessandro-Gabazza, Isaac Cann
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Publication number: 20230348616Abstract: An antibody that can be used as an anti-tumor agent and an anti-tumor agent comprises a molecule containing such an antibody. Such an antibody or a binding fragment thereof comprises: a heavy chain CDRH1 consisting of SEQ ID NO: 54, a heavy chain CDRH2 consisting of SEQ ID NO: 55, a heavy chain CDRH3 consisting of SEQ ID NO: 56, a light chain CDRL1 consisting of SEQ ID NO: 57 or a light chain CDRL1 consisting of an amino acid sequence derived from SEQ ID NO: 57 in which amino acid 7 is W and/or amino acid 8 is K, a light chain CDRL2 consisting of SEQ ID NO: 58, and a light chain CDRL3 consisting of SEQ ID NO: 59 or a light chain CDRL3 consisting of an amino acid sequence derived from SEQ ID NO: 59 in which amino acid 2 is A or S.Type: ApplicationFiled: March 29, 2021Publication date: November 2, 2023Applicants: MIE UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITEDInventors: Hiroshi SHIKU, Yasushi AKAHORI, Kento TANAKA, Ayaka YATSU, Junya ICHIKAWA, Toshiaki OHTSUKA, Shiho KOZUMA, Ryuji HASHIMOTO, Makiko NAKAYAMA, Naoya SHINOZAKI, Kensuke NAKAMURA, Ichiro WATANABE, Shinji FURUZONO
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Publication number: 20230287121Abstract: A novel antibody that can be used as an anti-tumor agent and an anti-tumor agent that comprises, as an active ingredient, a molecule containing such an antibody.Type: ApplicationFiled: May 16, 2023Publication date: September 14, 2023Applicants: MIE UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITEDInventors: Hiroshi SHIKU, Yasushi AKAHORI, Kento TANAKA, Ayaka YATSU, Junya ICHIKAWA, Toshiaki OHTSUKA, Shiho OKZUMA, Ryuji HASHIMOTO, Makiko NAKAYAMA, Naoya SHINOZAKI, Kensuke NAKAMURA, Ichiro WATANABE, Shinji FURUZONO
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Patent number: 11714068Abstract: The disclosure provides a method for preparing exosomes using: (i) a step for ultrafiltering a sample containing at least one exosome; and (ii) a step for subjecting the sample that can be obtained from step (i) to anion exchange column chromatography.Type: GrantFiled: July 31, 2019Date of Patent: August 1, 2023Assignee: Mie UniversityInventors: Hiroshi Shiku, Naohiro Seo, Tsuguhiro Kaneda, Junko Nakamura, Kazunari Akiyoshi
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Patent number: 11691551Abstract: To provide a technique that enables the reduction of fatigue of a vehicle occupant at low cost and without an increase in the number of parts. Without preparing a sensor in addition to a posture changing mechanism, the position of a lumbar vertebra or thoracic vertebra of each vehicle occupant is estimated by controlling the operation of the posture changing mechanism. The posture changing mechanism includes: a back side support mechanism; a first motor capable of shifting a position of the back side support mechanism with respect to a vertical direction; and a second motor capable of shifting the position of the back side support member with respect to a front-back direction.Type: GrantFiled: October 2, 2021Date of Patent: July 4, 2023Assignees: TACHI-S CO., LTD., MIE UNIVERSITYInventors: Masami Yoshida, Takumi Yamakawa, Soichiro Hayakawa, Ryojun Ikeura
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Publication number: 20230100683Abstract: A nitride semiconductor substrate (11, 21) includes: a substrate (2); and an AlN-containing film (100, 200) provided above the substrate (2). A thickness of the AlN-containing film (100, 200) is at most 10000 nm, and a threading dislocation density of the AlN-containing film (100, 200) is at most 2×108 cm?2.Type: ApplicationFiled: February 26, 2021Publication date: March 30, 2023Applicant: MIE UNIVERSITYInventors: Hideto MIYAKE, Ding WANG, Kenjiro UESUGI
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Patent number: 11574809Abstract: There is provided a method for manufacturing a nitride semiconductor template constituted by forming a nitride semiconductor layer on a substrate, comprising: (a) forming a first layer by epitaxially growing a nitride semiconductor containing aluminum on the substrate; (b) applying annealing to the first layer in an inert gas atmosphere; and (c) forming a second layer by epitaxially growing a nitride semiconductor containing aluminum on the first layer by a vapor phase growth after performing (b), and constituting the nitride semiconductor layer by the first layer and the second layer.Type: GrantFiled: December 5, 2017Date of Patent: February 7, 2023Assignees: SUMITOMO CHEMICAL COMPANY, LIMITED, MIE UNIVERSITYInventors: Hajime Fujikura, Taichiro Konno, Hideto Miyake
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Patent number: 11555819Abstract: A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.Type: GrantFiled: May 18, 2017Date of Patent: January 17, 2023Assignee: MIE UNIVERSITYInventors: Akira Mizoguchi, Koji Tanaka, Naoyuki Katayama, Tetsuya Nosaka, Kyosuke Tanaka, Shujie Wang, Aika Kaito, Kousyoku Sai, Kazushi Kimura
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Patent number: 11497768Abstract: CAR-T cells for cancer therapy are provided with an antibody that recognizes the MAGE-A4-derived-peptide/HLA-A2 complex. The antibody includes the VH amino acid sequence of SEQ ID NO: 36 and the VL amino acid sequence of SEQ ID NO: 38. The antibody preferably is provided with the amino acid sequence of SEQ ID NO: 32. Such CAR-T cells can be used in CAR infusion therapy in which a cancer-specific intracellular antigen is used.Type: GrantFiled: June 5, 2018Date of Patent: November 15, 2022Assignee: MIE UNIVERSITYInventors: Hiroshi Shiku, Yasushi Akahori, Yuya Kato, Yoshihiro Miyahara
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Publication number: 20220298196Abstract: Provided is a novel compound that is contained in a young watermelon fruit and has an antioxidative effect. The novel compound that is contained in a young watermelon fruit and is represented by the formula (1) or formula (2) has an antioxidative effect and further has a skin anti-aging effect. Since these compounds are extracts from plants that are naturally edible, they are very safe for human bodies. Therefore, an antioxidative pharmaceutical composition, an antioxidative processed food composition, and an anti-skin aging composition, which contain these compounds as active ingredients, have high utility value as highly safe compositions.Type: ApplicationFiled: June 17, 2020Publication date: September 22, 2022Applicants: HAGIHARA FARM PRODUCTION INSTITUTE CO., LTD., MIE UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEMInventors: Toshiharu HASHIZUME, Tomohiro ITOH, Mamoru KOKETSU, Masayuki NINOMIYA
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Patent number: 11415613Abstract: An optical waveguide 1, an optical waveguide 2 are formed on a substrate 3 to be crossed with each other, modulator electrodes 11, 12, 13 and 14 are arranged along the optical waveguides 1, 2, and antennas 21, 22, 23, 24 (i.e., square patch antennas having an approximately same shape) are arranged around four corners of the square shape. The modulator electrode 11 is energized from the antenna 21 and the antenna 22, the modulator electrode 12 is energized from the antenna 24 and the antenna 23, the modulator electrode 13 is energized from the antenna 21 and the antenna 24, and the modulator electrode 14 is energized from the antenna 22 and the antenna 23. The light wave propagating through the optical waveguide 1 is modulated by an electric field of Y-direction, and the light wave propagating through the optical waveguide 2 is modulated by an electric field of X-direction.Type: GrantFiled: March 19, 2020Date of Patent: August 16, 2022Assignees: MIE University, National Institute of Advanced Industrial Science and Technology, SEIKOH GIKEN Co., Ltd.Inventors: Hiroshi Murata, Satoru Kurokawa, Yoshikazu Toba, Masahiro Sato
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Publication number: 20220210990Abstract: A problem to be solved by the present invention is to provide a non-natural plant in which expression of a gene of interest is induced and a method for producing the same. Particularly, the present invention relates to a non-natural plant in which the expression of the gene is stably induced even in the absence of a physical or chemical stimulus inducing the expression of the gene, and a method for producing the same. When the induction of the expression of the gene enhances a trait of a plant of interest, the present invention provides a non-natural plant in which the trait is enhanced and a method for producing the same. To solve the problem, a non-natural regenerated plant in which the expression of the gene is induced can be produced by forming a callus from a portion of the plant of interest and then subjecting the callus to a treatment by which the expression of the gene is induced.Type: ApplicationFiled: April 21, 2020Publication date: July 7, 2022Applicant: National University Corporation Mie UniversityInventor: Issei Kobayashi