Patents Assigned to Mie University
  • Patent number: 11952423
    Abstract: A novel antibody that can be used as an anti-tumor agent and an anti-tumor agent that comprises, as an active ingredient, a molecule containing such an antibody.
    Type: Grant
    Filed: May 16, 2023
    Date of Patent: April 9, 2024
    Assignees: MIE UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Hiroshi Shiku, Yasushi Akahori, Kento Tanaka, Ayaka Yatsu, Junya Ichikawa, Toshiaki Ohtsuka, Shiho Kozuma, Ryuji Hashimoto, Makiko Nakayama, Naoya Shinozaki, Kensuke Nakamura, Ichiro Watanabe, Shinji Furuzono
  • Patent number: 11896680
    Abstract: Provided is a vital stain inspection method for distinguishing between cancer cells and normal cells within a lumen, or on the serous membrane side of an organ, by means of laser irradiation after organ tissue has been stained by curcumin, Red #3 or Red #106, which are edible color dyes.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: February 13, 2024
    Assignee: MIE University
    Inventors: Akira Mizoguchi, Koji Tanaka, Kazushi Kimura, Tetsuya Nosaka, Kyosuke Tanaka, Shujie Wang, Aika Kaito, Kousyoku Sai, Yuji Toiyama, Hidemasa Goto, Masahiko Sugimoto, Yuuhei Nishimura
  • Patent number: 11852632
    Abstract: A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: December 26, 2023
    Assignee: Mie University
    Inventors: Akira Mizoguchi, Koji Tanaka, Naoyuki Katayama, Tetsuya Nosaka, Kyosuke Tanaka, Shujie Wang, Aika Kaito, Kousyoku Sai, Kazushi Kimura
  • Publication number: 20230404938
    Abstract: A method of treating a patient in need thereof includes administering a therapeutically effective amount of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEH) to serve or function as a nerve growth factor (NGF) activity promoter, preferably to treat and/or prevent a neurodegenerative disease, such as PolyQ disease, Parkinson's disease, Parkinson's syndrome, spinocerebellar degeneration, spastic paraplegia, amyotrophic lateral sclerosis, Alzheimer's disease, dementia with Lewy bodies or corticobasal degeneration.
    Type: Application
    Filed: March 16, 2023
    Publication date: December 21, 2023
    Applicant: MIE UNIVERSITY
    Inventors: Toshiyuki SHIBATA, Hideo MIYAKE, Reiji TANAKA, Fumino OKUDA, Mano HASEGAWA
  • Publication number: 20230357373
    Abstract: Staphylococcus nepalensis releases corisin, a peptide conserved in diverse Staphylococci, that induces apoptosis of lung epithelial cells. Therefore, methods and apparatus for detecting the presence of corisin in a biological sample of a patient are disclosed, as well as pharmaceutical compositions, such as antibodies, and methods for treating patents having or suspected of having fibrosis.
    Type: Application
    Filed: December 16, 2020
    Publication date: November 9, 2023
    Applicants: Mie University, The Board of Trustees of the University of Illinois
    Inventors: Esteban Gabazza, Corina D'Alessandro-Gabazza, Isaac Cann
  • Publication number: 20230348616
    Abstract: An antibody that can be used as an anti-tumor agent and an anti-tumor agent comprises a molecule containing such an antibody. Such an antibody or a binding fragment thereof comprises: a heavy chain CDRH1 consisting of SEQ ID NO: 54, a heavy chain CDRH2 consisting of SEQ ID NO: 55, a heavy chain CDRH3 consisting of SEQ ID NO: 56, a light chain CDRL1 consisting of SEQ ID NO: 57 or a light chain CDRL1 consisting of an amino acid sequence derived from SEQ ID NO: 57 in which amino acid 7 is W and/or amino acid 8 is K, a light chain CDRL2 consisting of SEQ ID NO: 58, and a light chain CDRL3 consisting of SEQ ID NO: 59 or a light chain CDRL3 consisting of an amino acid sequence derived from SEQ ID NO: 59 in which amino acid 2 is A or S.
    Type: Application
    Filed: March 29, 2021
    Publication date: November 2, 2023
    Applicants: MIE UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Hiroshi SHIKU, Yasushi AKAHORI, Kento TANAKA, Ayaka YATSU, Junya ICHIKAWA, Toshiaki OHTSUKA, Shiho KOZUMA, Ryuji HASHIMOTO, Makiko NAKAYAMA, Naoya SHINOZAKI, Kensuke NAKAMURA, Ichiro WATANABE, Shinji FURUZONO
  • Publication number: 20230287121
    Abstract: A novel antibody that can be used as an anti-tumor agent and an anti-tumor agent that comprises, as an active ingredient, a molecule containing such an antibody.
    Type: Application
    Filed: May 16, 2023
    Publication date: September 14, 2023
    Applicants: MIE UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Hiroshi SHIKU, Yasushi AKAHORI, Kento TANAKA, Ayaka YATSU, Junya ICHIKAWA, Toshiaki OHTSUKA, Shiho OKZUMA, Ryuji HASHIMOTO, Makiko NAKAYAMA, Naoya SHINOZAKI, Kensuke NAKAMURA, Ichiro WATANABE, Shinji FURUZONO
  • Patent number: 11714068
    Abstract: The disclosure provides a method for preparing exosomes using: (i) a step for ultrafiltering a sample containing at least one exosome; and (ii) a step for subjecting the sample that can be obtained from step (i) to anion exchange column chromatography.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: August 1, 2023
    Assignee: Mie University
    Inventors: Hiroshi Shiku, Naohiro Seo, Tsuguhiro Kaneda, Junko Nakamura, Kazunari Akiyoshi
  • Patent number: 11691551
    Abstract: To provide a technique that enables the reduction of fatigue of a vehicle occupant at low cost and without an increase in the number of parts. Without preparing a sensor in addition to a posture changing mechanism, the position of a lumbar vertebra or thoracic vertebra of each vehicle occupant is estimated by controlling the operation of the posture changing mechanism. The posture changing mechanism includes: a back side support mechanism; a first motor capable of shifting a position of the back side support mechanism with respect to a vertical direction; and a second motor capable of shifting the position of the back side support member with respect to a front-back direction.
    Type: Grant
    Filed: October 2, 2021
    Date of Patent: July 4, 2023
    Assignees: TACHI-S CO., LTD., MIE UNIVERSITY
    Inventors: Masami Yoshida, Takumi Yamakawa, Soichiro Hayakawa, Ryojun Ikeura
  • Publication number: 20230100683
    Abstract: A nitride semiconductor substrate (11, 21) includes: a substrate (2); and an AlN-containing film (100, 200) provided above the substrate (2). A thickness of the AlN-containing film (100, 200) is at most 10000 nm, and a threading dislocation density of the AlN-containing film (100, 200) is at most 2×108 cm?2.
    Type: Application
    Filed: February 26, 2021
    Publication date: March 30, 2023
    Applicant: MIE UNIVERSITY
    Inventors: Hideto MIYAKE, Ding WANG, Kenjiro UESUGI
  • Patent number: 11574809
    Abstract: There is provided a method for manufacturing a nitride semiconductor template constituted by forming a nitride semiconductor layer on a substrate, comprising: (a) forming a first layer by epitaxially growing a nitride semiconductor containing aluminum on the substrate; (b) applying annealing to the first layer in an inert gas atmosphere; and (c) forming a second layer by epitaxially growing a nitride semiconductor containing aluminum on the first layer by a vapor phase growth after performing (b), and constituting the nitride semiconductor layer by the first layer and the second layer.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: February 7, 2023
    Assignees: SUMITOMO CHEMICAL COMPANY, LIMITED, MIE UNIVERSITY
    Inventors: Hajime Fujikura, Taichiro Konno, Hideto Miyake
  • Patent number: 11555819
    Abstract: A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: January 17, 2023
    Assignee: MIE UNIVERSITY
    Inventors: Akira Mizoguchi, Koji Tanaka, Naoyuki Katayama, Tetsuya Nosaka, Kyosuke Tanaka, Shujie Wang, Aika Kaito, Kousyoku Sai, Kazushi Kimura
  • Patent number: 11497768
    Abstract: CAR-T cells for cancer therapy are provided with an antibody that recognizes the MAGE-A4-derived-peptide/HLA-A2 complex. The antibody includes the VH amino acid sequence of SEQ ID NO: 36 and the VL amino acid sequence of SEQ ID NO: 38. The antibody preferably is provided with the amino acid sequence of SEQ ID NO: 32. Such CAR-T cells can be used in CAR infusion therapy in which a cancer-specific intracellular antigen is used.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: November 15, 2022
    Assignee: MIE UNIVERSITY
    Inventors: Hiroshi Shiku, Yasushi Akahori, Yuya Kato, Yoshihiro Miyahara
  • Publication number: 20220298196
    Abstract: Provided is a novel compound that is contained in a young watermelon fruit and has an antioxidative effect. The novel compound that is contained in a young watermelon fruit and is represented by the formula (1) or formula (2) has an antioxidative effect and further has a skin anti-aging effect. Since these compounds are extracts from plants that are naturally edible, they are very safe for human bodies. Therefore, an antioxidative pharmaceutical composition, an antioxidative processed food composition, and an anti-skin aging composition, which contain these compounds as active ingredients, have high utility value as highly safe compositions.
    Type: Application
    Filed: June 17, 2020
    Publication date: September 22, 2022
    Applicants: HAGIHARA FARM PRODUCTION INSTITUTE CO., LTD., MIE UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
    Inventors: Toshiharu HASHIZUME, Tomohiro ITOH, Mamoru KOKETSU, Masayuki NINOMIYA
  • Patent number: 11415613
    Abstract: An optical waveguide 1, an optical waveguide 2 are formed on a substrate 3 to be crossed with each other, modulator electrodes 11, 12, 13 and 14 are arranged along the optical waveguides 1, 2, and antennas 21, 22, 23, 24 (i.e., square patch antennas having an approximately same shape) are arranged around four corners of the square shape. The modulator electrode 11 is energized from the antenna 21 and the antenna 22, the modulator electrode 12 is energized from the antenna 24 and the antenna 23, the modulator electrode 13 is energized from the antenna 21 and the antenna 24, and the modulator electrode 14 is energized from the antenna 22 and the antenna 23. The light wave propagating through the optical waveguide 1 is modulated by an electric field of Y-direction, and the light wave propagating through the optical waveguide 2 is modulated by an electric field of X-direction.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: August 16, 2022
    Assignees: MIE University, National Institute of Advanced Industrial Science and Technology, SEIKOH GIKEN Co., Ltd.
    Inventors: Hiroshi Murata, Satoru Kurokawa, Yoshikazu Toba, Masahiro Sato
  • Publication number: 20220210990
    Abstract: A problem to be solved by the present invention is to provide a non-natural plant in which expression of a gene of interest is induced and a method for producing the same. Particularly, the present invention relates to a non-natural plant in which the expression of the gene is stably induced even in the absence of a physical or chemical stimulus inducing the expression of the gene, and a method for producing the same. When the induction of the expression of the gene enhances a trait of a plant of interest, the present invention provides a non-natural plant in which the trait is enhanced and a method for producing the same. To solve the problem, a non-natural regenerated plant in which the expression of the gene is induced can be produced by forming a callus from a portion of the plant of interest and then subjecting the callus to a treatment by which the expression of the gene is induced.
    Type: Application
    Filed: April 21, 2020
    Publication date: July 7, 2022
    Applicant: National University Corporation Mie University
    Inventor: Issei Kobayashi
  • Patent number: 11344632
    Abstract: The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: May 31, 2022
    Assignees: NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Katsunori Teranishi, Hitoshi Hirata, Tetsuya Arai
  • Publication number: 20220135514
    Abstract: Phytol contained in watermelon sprouts is known to have a cancer cell growth inhibiting effect. However, there is a problem that an amount of phytol to be taken for exhibiting cancer cell growth inhabition is large. A cancer cell growth inhibiting composition comprising at least one of compounds having a structure represented by Formula (1), Formula (2), Formula (6), Formula (7) or Formula (8), or a pharmaceutically acceptable salt thereof as main components has a higher cancer cell growth inhibiting effect than phytol.
    Type: Application
    Filed: February 21, 2020
    Publication date: May 5, 2022
    Applicants: HAGIHARA FARM PRODUCTION INSTITUTE CO., LTD., KINKI UNIVERSITY, MIE UNIVERSITY
    Inventors: Toshiharu HASHIZUME, Takashi KITAYAMA, Gengo KASHIWAZAKI, Satoru HIRABAYASHI, Yoshimi UTAKA, Keigo TANEDA, Tomohiro ITOH
  • Patent number: 11293870
    Abstract: A vital stain for observation under multiphoton laser microscopy, the vital stain comprising one or more edible dye compounds.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: April 5, 2022
    Assignee: MIE UNIVERSITY
    Inventors: Akira Mizoguchi, Takeshi Fujiwara, Koji Tanaka, Shujie Wang, Kousyoku Sai, Kazushi Kimura
  • Patent number: 11179450
    Abstract: A long-chain peptide antigen includes a plurality of epitopes. An interepitope sequence located between two of the plurality of epitopes contains four to ten consecutive tyrosines. The long-chain peptide antigen may be administered to a patient together with a hydrophobized polysaccharide, such as cholesterol-modified pullulan, and/or an adjuvant, such as CpG oligo DNA.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: November 23, 2021
    Assignees: MIE UNIVERSITY, KYOTO UNIVERSITY
    Inventors: Hiroshi Shiku, Naozumi Harada, Daisuke Muraoka, Kazunari Akiyoshi