Patents Assigned to MIGENIX Corp.
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Publication number: 20080171034Abstract: Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein.Type: ApplicationFiled: October 25, 2007Publication date: July 17, 2008Applicant: MIGENIX Corp.Inventor: Yazhong Pei
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Publication number: 20080032981Abstract: Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.Type: ApplicationFiled: May 4, 2007Publication date: February 7, 2008Applicant: MIGENIX CORP.Inventors: Soumitra Ghosh, Tomas Szabo
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Patent number: 7304171Abstract: Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein.Type: GrantFiled: May 26, 2005Date of Patent: December 4, 2007Assignee: Migenix Corp.Inventor: Yazhong Pei
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Patent number: 7230132Abstract: Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.Type: GrantFiled: January 21, 2005Date of Patent: June 12, 2007Assignee: Migenix Corp.Inventors: Soumitra S Ghosh, Tomas R Szabo
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Publication number: 20070021496Abstract: The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the treatment of arthritic disorders, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.Type: ApplicationFiled: June 29, 2005Publication date: January 25, 2007Applicants: MIGENIX Corp., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Robert Terkeltaub, Anne Murphy, James Dykens, Soumitra Ghosh, Robert Davis, Andrew Granston
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Publication number: 20060194825Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.Type: ApplicationFiled: December 19, 2003Publication date: August 31, 2006Applicant: MIGENIX Corp.Inventors: Soumitra Ghosh, Yazhong Pei, Xiao-Qing Tang, Spiros Liras, Michael Ahlijanian
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Patent number: 7005274Abstract: The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the treatment of arthritic disorders, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.Type: GrantFiled: September 14, 2000Date of Patent: February 28, 2006Assignees: MIGENIX Corp., The Regents of the University of CaliforniaInventors: Robert Terkeltaub, Anne N. Murphy, James A. Dykens, Soumitra S. Ghosh, Robert E. Davis, Andrew E. Granston, Jr.
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Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
Patent number: 7001729Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.Type: GrantFiled: March 14, 2001Date of Patent: February 21, 2006Assignee: Migenix Corp.Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley, Scott W. Miller, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei -
Publication number: 20060004093Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.Type: ApplicationFiled: June 7, 2005Publication date: January 5, 2006Applicants: MIGENIX Corp., Pfizer Inc.Inventors: Soumitra Ghosh, Yazhong Pei, Xiao-Qing Tang, Spiros Liras, Michael Ahlijanian
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Publication number: 20050267086Abstract: Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein.Type: ApplicationFiled: May 26, 2005Publication date: December 1, 2005Applicant: MIGENIX Corp.Inventor: Yazhong Pei
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Patent number: 6936638Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.Type: GrantFiled: December 19, 2003Date of Patent: August 30, 2005Assignees: Migenix Corp., Pfizer Inc.Inventors: Soumitra S. Ghosh, Yazhong Pei, Xiao-Qing Tang, Spiros J. Liras, Michael K. Ahlijanian
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Publication number: 20050182057Abstract: Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.Type: ApplicationFiled: January 21, 2005Publication date: August 18, 2005Applicant: MIGENIX Corp.Inventors: Soumitra Ghosh, Tomas Szabo
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Patent number: 6927218Abstract: Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.Type: GrantFiled: March 11, 2003Date of Patent: August 9, 2005Assignee: Migenix Corp.Inventors: Soumitra S. Ghosh, Tomas R. Szabo
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Publication number: 20050170329Abstract: The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.Type: ApplicationFiled: October 26, 2004Publication date: August 4, 2005Applicant: MIGENIX Corp.Inventors: Anne Murphy, Amy Stout
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Publication number: 20050148768Abstract: Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.Type: ApplicationFiled: November 8, 2004Publication date: July 7, 2005Applicant: MIGENIX Corp.Inventors: Tomas Szabo, Soumitra Ghosh, Robert Davis
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Patent number: 6906175Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.Type: GrantFiled: March 16, 2001Date of Patent: June 14, 2005Assignee: MIGENIX Corp.Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley, Scott W. Miller, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei
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Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
Patent number: 6906174Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.Type: GrantFiled: March 16, 2001Date of Patent: June 14, 2005Assignee: Migenix Corp.Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley -
Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
Patent number: 6906173Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.Type: GrantFiled: November 3, 1998Date of Patent: June 14, 2005Assignee: Migenix Corp.Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley -
Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
Patent number: 6902908Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.Type: GrantFiled: March 14, 2001Date of Patent: June 7, 2005Assignee: Migenix Corp.Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley, Scott W. Miller, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei -
Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
Patent number: 6887670Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.Type: GrantFiled: March 14, 2001Date of Patent: May 3, 2005Assignee: MIGENIX Corp.Inventors: Christen M. Anderson, Robert E. Davis, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei