Abstract: Disclosed are protein kinase inhibitors of Formula Ia and Ib, compositions comprising such inhibitors, and methods of use, thereof. More particularly, these compounds and compositions are inhibitors of Aurora-A (Aurora-2) and Aurora-B (Aurora-1) protein kinase. Also disclosed are methods of using these compounds and compositions to prevent and treat diseases associated with protein kinases, especially diseases associated with Aurora-A or Aurora-B, such as cancer.
Abstract: Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.
Type:
Grant
Filed:
June 30, 2009
Date of Patent:
February 14, 2012
Assignee:
Miikana Therapeutics, Inc.
Inventors:
Xiao-Yi Xiao, Dinish V. Patel, John S. Ward, Mark R. Bray, Gregory E. Agoston, Anthony M. Treston
Abstract: Provided are substituted pyrazole compounds which are useful as protein kinase inhibitors, compositions comprising the compounds, and methods of use thereof. The protein kinase inhibitors are particularly for inhibition of Aurora A (Aurora-2) protein kinase and are useful in the treatment of diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.
Type:
Application
Filed:
November 23, 2009
Publication date:
December 29, 2011
Applicant:
MIIKANA THERAPEUTICS, INC.
Inventors:
Gaetan Ladouceur, Gregory A. Agosto, Jamshed H. Shah, Lita Suwandi, Nnamdi Ofoegbu
Abstract: Disclosed are compounds of formula I that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.
Type:
Grant
Filed:
February 14, 2006
Date of Patent:
August 10, 2010
Assignee:
Miikana Therapeutics, Inc.
Inventors:
Sampath K. Anandan, Xiao-Yi Xiao, John S. Ward, Dinesh V. Patel
Abstract: Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.
Type:
Grant
Filed:
September 29, 2006
Date of Patent:
July 21, 2009
Assignee:
Miikana Therapeutics, Inc.
Inventors:
Xiao-Yi Xiao, Dinish V. Patel, John S. Ward, Mark R. Bray, Gregory E. Agoston, Anthony M. Treston
Abstract: Disclosed are compounds that inhibit proteasomic activity in cells. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly cell proliferative conditions, such as cancer and inflammatory conditions.
Abstract: Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.
Type:
Grant
Filed:
April 1, 2005
Date of Patent:
March 18, 2008
Assignee:
Miikana Therapeutics
Inventors:
Sampath K. Anandan, Xiao-Yi Xiao, Dinesh V. Patel, John Ward
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