Patents Assigned to MIKROCHEM spol. s r.o.
  • Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide
    Patent number: 11680052
    Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(dimethylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: June 20, 2023
    Assignee: MIKROCHEM SPOL. S R.O.
    Inventors: Daniela Benadiková, Juraj Cech, Erik Juhás, Vladimír Oremus, Vendel {hacek over (S)}mahovský
  • METHOD FOR PREPARATION OF 3,7-BIS-(DIMETHYLAMINO)-PHENOTHIAZIN-5-IUM CHLORIDE OR BROMIDE
    Publication number: 20210292288
    Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(dimethylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.
    Type: Application
    Filed: June 9, 2021
    Publication date: September 23, 2021
    Applicant: MIKROCHEM spol. s r.o.
    Inventors: Daniela BENADIKOVÁ, Juraj CECH, Erik JUHÁS, Vladimír OREMUS, Vendel SMAHOVSKÝ
  • Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide
    Patent number: 11059797
    Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(di-methylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: July 13, 2021
    Assignee: MIKROCHEM SPOL. S R.O.
    Inventors: Daniela Benadiková, Juraj Cech, Erik Juhás, Vladimír Oremus, Vendel {hacek over (S)}mahovský
  • METHOD FOR PREPARATION OF 3,7-BIS-(DIMETHYLAMINO)-PHENOTHIAZIN-5-IUM CHLORIDE OR BROMIDE
    Publication number: 20200010436
    Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(di-methylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.
    Type: Application
    Filed: March 15, 2018
    Publication date: January 9, 2020
    Applicant: MIKROCHEM spol. s r.o.
    Inventors: Daniela BENADIKOVÁ, Juraj CECH, Erik JUHÁS, Vladimír OREMUS, Vendel SMAHOVSKÝ