Abstract: A machine tool (1, 1?), in particular a drilling and milling machine, comprising a housing (20) having a machine bed (2), together with side walls (3, 4) and doors (5, 6, 7), comprising a fixed, pivotable or rotatable work table (8, 9), and comprising a slide (10), transportable in the y direction, for the reception of a spindle head (11), transportable in the x-z direction, for the reception of tools (12), wherein the front door (5), for the enlargement of the working and loading area (21) in the upward direction, is of transomless configuration, the roof region (13) of the machine (1, 1?) has an automatically operable cover (16), the rear region (22) of the machine (1, 1?) has an integrable automatic pallet changer (14), and the machine (1, 1?) is assigned an automatic tool changer (15).