Patents Assigned to Milagen, Inc.
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Patent number: 10031130Abstract: The present invention is a device for high-throughput detection, screening and disease management of cervical disease. The device is comprised of a solid support featuring multiple well-separated areas, each accommodating a patient sample, leading to simultaneous evaluation of patient samples. The device enables cytological staining, cervical Pap staining, and immunochemical staining using antibodies or combination of antibodies which are capable of binding to biomarkers that are overexpressed in cancer including in cervical carcinoma and dysplasia, as compared to normal controls. The device can be used in either manual or automated mode, and applied to any biological fluid or cell suspension from any biological specimen in view of a variety of cell biology assays, and in view of detection and screening of cervical and other diseases.Type: GrantFiled: January 23, 2017Date of Patent: July 24, 2018Assignee: MILAGEN, INC.Inventor: Moncef Jendoubi
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Patent number: 9551700Abstract: The present invention discloses a novel device and methods thereof with utility application in the high-throughput detection, screening and disease management of cervical disease. The “multiwell” device of the present invention consists of a solid support featuring multiple well-separated areas, each accommodating a patient sample, leading to simultaneous evaluation of patient samples. The methods of the present invention comprise conventional cytological staining, cervical Pap staining, and immunochemical staining using antibodies or combination of antibodies which are capable of binding to biomarkers that are overexpressed in cancer including in cervical carcinoma and dysplasia, as compared to normal controls. The device and methods of the present invention can be practiced in either manual or automated mode, and applied to any biological fluid or cell suspension from any biological specimen in view of a variety of cell biology assays, and in view of detection and screening of cervical and other diseases.Type: GrantFiled: December 20, 2010Date of Patent: January 24, 2017Assignee: MILAGEN, INC.Inventor: Moncef Jendoubi
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Publication number: 20120156698Abstract: The present invention discloses a novel device and methods thereof with utility application in the high-throughput detection, screening and disease management of cervical disease. The “multiwell” device of the present invention consists of a solid support featuring multiple well-separated areas, each accommodating a patient sample, leading to simultaneous evaluation of patient samples. The methods of the present invention comprise conventional cytological staining, cervical Pap staining, and immunochemical staining using antibodies or combination of antibodies which are capable of binding to biomarkers that are overexpressed in cancer including in cervical carcinoma and dysplasia, as compared to normal controls. The device and methods of the present invention can be practiced in either manual or automated mode, and applied to any biological fluid or cell suspension from any biological specimen in view of a variety of cell biology assays, and in view of detection and screening of cervical and other diseases.Type: ApplicationFiled: December 20, 2010Publication date: June 21, 2012Applicant: MILAGEN, INC.Inventor: MONCEF JENDOUBI
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Publication number: 20120157767Abstract: The present invention relates to a digital system for cervical disease screening and detection, with clinical application as adjunct to Pap smear. The device of the present invention is designed for insertion into a woman's genital cavity, and is composed of a digital camera and light source at one end to take pictures of the cervix and its environment, of a flexible tubing connecting said end to a distal end, and of a distal end comprising a digital mean with capacity to store images, display, transfer and share them as required, on-site or at a remote location. This instrument can either be used by a health professional, or self-operated. The present invention provides a system making cervical disease screening routinely accessible to every woman, by improving frequency and cost-effectiveness of cervical disease surveillance in general, and facilitating access to health care professionals even to women in rural or underserved areas.Type: ApplicationFiled: December 20, 2010Publication date: June 21, 2012Applicant: MILAGEN, INC.Inventor: MONCEF JENDOUBI
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Publication number: 20030060603Abstract: The present invention is directed to the production of antibodies drawn to the gene products of polynucleotides expressed through genetic immunization. The antibodies are correlated on a one-to-one basis with the gene sequences encoding the gene products to which the antibodies are specific. The polynucleotides are placed in recombinant vector constructs for expression and may be used without knowledge of the open reading frame. The antibodies may be used to analyze gene expression and protein expression profiling for research, diagnostics, or therapeutics.Type: ApplicationFiled: August 30, 2002Publication date: March 27, 2003Applicant: Milagen, Inc.Inventor: Moncef Jendoubi
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Publication number: 20030049626Abstract: The present invention is directed to a protein matrix wherein biological samples, preferably proteins, are placed on a solid support. The arrays are reacted with identifier molecules, such as antibodies, to correlate the gene expression manifested in the samples with the identifier molecule. The reaction produces a gene expression or protein expression profile for the biological state from which the samples are derived. The arrays are used for research, drug discovery, and the detection of disease.Type: ApplicationFiled: August 14, 2001Publication date: March 13, 2003Applicant: Milagen, Inc.Inventor: Moncef Jendoubi
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Publication number: 20030013208Abstract: The present invention is directed to an array of antibodies drawn to the gene products of a cell, where the antibodies are bound to a solid support. The antibodies of the antibody array are correlated on a one-to-one basis with the gene sequences to which the individual antibodies of the array are specific. Also, methods for use of the arrays to analyze gene expression profiling and the detection of disease are described.Type: ApplicationFiled: July 13, 2001Publication date: January 16, 2003Applicant: Milagen, Inc.Inventor: Moncef Jendoubi
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Publication number: 20030003497Abstract: The present invention includes a basic method for discovering the function of gene and their corresponding gene products relative to a specific biological process or physiological condition. The invention provides the ability to develop therapeutic and diagnostic agents using the information obtained from the practice of the basic method. In the method, the gene product of a selected polynucleotide is delivered to a mammal to provide an immune response. The polynucleotide sequences may express, in vivo by immunization of an animal, or in bacterial system or other known system for expression of a polynucleotide sequence. The sera resulting from immunization with the gene product contains antibodies to the gene product which are used in function determinative assays to determine the function of the gene sequence gene product relative to a biological process or physiological condition, typically a disease in a human.Type: ApplicationFiled: August 5, 2002Publication date: January 2, 2003Applicant: Milagen, Inc.Inventor: Moncef Jendoubi