Patents Assigned to Millennium Pharmaceuticals
  • 14790, a novel protein kinase molecule and uses therefor
    Patent number: 7198929
    Abstract: The invention provides an isolated nucleic acid molecule, designated as a kinase nucleic acid molecule, which encodes a novel protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing kinase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. The invention still further provides isolated 14790 proteins, fusion proteins, antigenic peptides and anti-kinase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: April 3, 2007
    Assignees: Millennium Pharmaceuticals, Bayer Corporation
    Inventors: William James Cook, Rosana Kapeller-Libermann, Helga Rubsamen-Waigmann, Frank Spaltmann
  • CCR1 antagonists and methods of use therefor
    Publication number: 20040106639
    Abstract: The invention provides compounds having the formula: 1
    Type: Application
    Filed: November 12, 2003
    Publication date: June 3, 2004
    Applicant: Millennium Pharmaceuticals
    Inventors: Kenneth G. Carson, Geraldine C.B. Harriman
  • 32142, 21481, 25964, 21686, novel dehydrogenase molecules and uses therefor
    Publication number: 20040077010
    Abstract: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: September 17, 2003
    Publication date: April 22, 2004
    Applicant: Millennium Pharmaceuticals
    Inventors: Rachel Meyers, William James Cook, Mark Williamson, Laura A. Rudolph-Owen, Ruth Gimeno
  • Nucleic acids encoding defense inducible proteins and uses thereof
    Publication number: 20020170089
    Abstract: The invention provides isolated AFP1 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering AFP1 concentration and/or composition of plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions.
    Type: Application
    Filed: February 28, 2002
    Publication date: November 14, 2002
    Applicant: Millennium Pharmaceuticals
    Inventor: Carl R. Simmons
  • 2786, a novel human aminopeptidase
    Publication number: 20020076796
    Abstract: The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
    Type: Application
    Filed: May 14, 2001
    Publication date: June 20, 2002
    Applicant: Millennium Pharmaceuticals
    Inventors: Rosana Kapeller-Libermann, David White, Kyle J. MacBeth
  • Compositions for the diagnosis and treatment of Chediak-Higashi syndrome
    Patent number: 5952223
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the differentiation and/or function of intracellular vesicles. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian bg gene, a gene that, when mutated, is responsible for the human Chediak-Higashi syndrome.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: September 14, 1999
    Assignees: Millennium Pharmaceuticals, The University of Utah Research Foundation
    Inventors: Jerry Kaplan, Charles M. Perou, Karen J. Moore