Abstract: Novel CARD-5 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to CARD-5 proteins, and the invention further provides CARD-5 fusion proteins, antigenic peptides and anti-CARD-5 antibodies. The invention also provides CARD-5 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-5 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: Disclosed are essential Aspergillus polypeptides and genes (AN97, AN17, AN80, and AN85), as well as homologs thereof, which can be used to identify antifungal agents for treating fungal infections such as aspergillosis.

Abstract: The invention provides isolated nucleic acids molecules, designated AZAD nucleic acid molecules, which encode novel secreted proteins containing multiple leucine rich repeats. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing AZAD nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an AZAD gene has been introduced or disrupted. The invention still further provides isolated AZAD proteins, fusion proteins, antigenic peptides and anti-AZAD antibodies. Diagnostic methods utilizing compositions of the invention are also provided.