Abstract: The invention provides isolated nucleic acids molecules, designated TP-2 nucleic acid molecules, which encode novel transporter family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TP-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TP-2 gene has been introduced or disrupted. The invention still further provides isolated TP-2 polypeptides, fusion polypeptides, antigenic peptides and anti-TP-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention relates to nucleic acid molecules encoding CARD-3, nucleic acid molecules encoding CARD-4, CARD-3 polypeptides, CARD-4 polypeptides, and uses thereof.

Abstract: The invention provides isolated nucleic acids molecules, including 69087 nucleic acid molecules, which encode a novel G protein coupled receptor kinase, 15821 nucleic acid molecules, which encode a novel nuclear signaling protein, and 15418 nucleic acid molecules, which encode a mitogen-activated protein kinase phosphatase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 69087, 15821, or 15418 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 69087, 15821, or 15418 gene has been introduced or disrupted. The invention still further provides isolated 69087, 15821, and 15418 proteins, fusion proteins, antigenic peptides and anti-69087, anti-15821, and anti-15418 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated HNMDA-1 nucleic acid molecules, which encode novel glutamate-gated ion channel family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HNMDA-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HNMDA-1 gene has been introduced or disrupted. The invention still further provides isolated HNMDA-1 polypeptides, fusion polypeptides, antigenic peptides and anti-HNMDA-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated NT69 nucleic acid molecules, which encode a novel nucleoside transporter family member. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing NT69 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an NT69 gene has been introduced or disrupted. The invention still further provides isolated NT69 proteins, fusion proteins, antigenic peptides and anti-NT69 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acid molecules, including 58569 nucleic acid molecules, which encode a novel human anion exchange protein and 50111 molecules, which encode a novel human FGGY-like carbohydrate kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 58569 or 50111 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 58569 or 50111 gene has been introduced or disrupted. The invention still further provides isolated 58569 or 50111 proteins, fusion proteins, antigenic peptides and anti-58569 and anti-50111 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to GPR-9-6 and inhibit the binding of a ligand (e.g., TECK) and/or modulate a function of GPR-9-6. The invention further relates to a method of modulating a function of GPR-9-6, and to the use of the antibodies, antigen-binding fragments and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.

Abstract: Disclosed are essential Aspergillus polypeptides and genes (AN97, AN17, AN80, and AN85), as well as homologs thereof, which can be used to identify antifungal agents for treating fungal infections such as aspergillosis.

Abstract: Six genes whose expression is induced by leptin are disclosed (LIG46; LIG56; Tgtp, encoding a T cell-specific GTP-binding protein; LRG-47, encoding an interferon (IFN) inducible protein; RC10-II, encoding a subunit of a 20S brain proteasome; and Stra13, encoding a retinoic acid inducible protein). These six leptin-inducible genes and the proteins they encode represent targets for the development of therapeutic agents for use in modulating body weight. For example, agents that alter the expression or activity of one or more of the leptin-induced proteins can be used to modulate body weight. Such agents can be identified using cellular, in vitro, or in vivo assays which monitor the expression or activity of one or more of the six leptin-induced proteins. Potentially useful therapeutic agents can also be identified through the use of assays designed to identify agents that bind to one of the leptin-induced proteins.

Abstract: The invention provides isolated nucleic acids molecules, designated 67073 nucleic acid molecules, which encode novel phospholipid transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 67073 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 67073 gene has been introduced or disrupted. The invention still further provides isolated 67073 proteins, fusion proteins, antigenic peptides and anti-67073 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: Novel T129 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length T129 proteins, the invention further provides isolated T129 fusion proteins, antigenic peptides and anti-T129 antibodies. The invention also provides T129 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a T129 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: An instrument for inserting an implant between vertebral bodies, including a holder adapted to hold the implant during insertion of the implant between the vertebral bodies, a retractor adapted to retract the holder away from the implant after the insertion, and a guard adapted to prevent the implant from being removed from between the vertebral bodies during the retraction.

Abstract: The invention provides isolated nucleic acids molecules, designated HGT-1 nucleic acid molecules, which encode novel galactosyltransferase family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HGT-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HGT-1 gene has been introduced or disrupted. The invention still further provides isolated HGT-1 polypeptides, fusion polypeptides, antigenic peptides and anti-HGT-1 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 22406 nucleic acid molecules, which encode a novel pyridoxal-phosphate dependent enzyme family member. In particular, the invention relates to 22406 serine racemase polypeptide and encoding nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 22406 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 22406 gene has been introduced or disrupted. The invention still further provides isolated 22406 proteins, fusion proteins, antigenic peptides and anti-22406 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated CDAP nucleic acid molecules, which are differentially expressed in cells undergoing programmed cell death. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CDAP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CDAP gene has been introduced or disrupted. The invention still further provides isolated CDAP proteins, fusion proteins, antigenic peptides and anti-CDAP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: Novel HKID-1 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length HKID-1 proteins, the invention further provides isolated HKID-1 fusion proteins, antigenic peptides and anti-HKID-1 antibodies. The invention also provides HKID-1 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an HKID-1 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: Disclosed is a gene, termed “S-yneS,” found in Streptococcus pneumoniae, which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as well as homologs and orthologs thereof (collectively referred to as “yneS” genes and polypeptides) can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Abstract: The invention provides isolated nucleic acids molecules, designated 47169 and 33935 nucleic acid molecules, which encode novel glycosyl transferases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47169 and 33935 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 47169 or 33935 gene has been introduced or disrupted. The invention still further provides isolated 47169 and 33935 proteins, fusion proteins, antigenic peptides and anti-47169 and anti-33935 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The present invention relates, first, to the identification of novel nucleic acid molecules, termed RATH genes and RATH gene products encoded by such nucleic acid molecules, or degenerate variants thereof, that participate in the regulation, control and/or modulation of G-protein-mediated signal transduction involved in T cell activation, including, but not limited to T helper (TH) cell and TH cell subpopulation activation. Specifically, the nucleic acid molecules of the present invention include the genes corresponding to the mammalian RATH genes, including the RATH1.1 genes. Sequence analysis indicates that the RATH genes are novel genes belonging to the RGS (“regulator of G-protein signalling”) gene family, a gene family which encodes gene products involved in G-protein-mediated signal transduction.

Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the differentiation and/or function of intracellular vesicles. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian bg gene, a gene that, when mutated, is responsible for the human Chediak-Higashi syndrome.