Patents Assigned to Mind Medicine, Inc.
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Publication number: 20250019359Abstract: A composition of a crystalline form salt or polymorph of R-MDMA. A pharmaceutical composition of a crystalline form salt or polymorph of R-MDMA and pharmaceutically acceptable excipients. A method of treating an individual for a medical condition, by administering an effective amount of a composition of a crystalline form salt or polymorph of R-MDMA to the individual and treating the individual.Type: ApplicationFiled: March 20, 2024Publication date: January 16, 2025Applicant: Mind Medicine, Inc.Inventors: Stephen E. SCHNEIDER, Gillian MOORE, Julian Scott NORTHEN
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Patent number: 12097184Abstract: A composition of psilocin that is stable including at least one agent or chemical modification that provides enhanced stability. A method making stable psilocin, by providing a formulation of psilocin including at least one agent or chemical modification that provides enhanced stability. A method of treatment of a disease or condition, by administering a composition of psilocin that is stable to an individual and treating the disease or condition.Type: GrantFiled: May 31, 2023Date of Patent: September 24, 2024Assignee: Mind Medicine, Inc.Inventors: Robert Barrow, Peter Mack, Stephen Schneider, Jon Schroeder, Gerald S. Jones
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Publication number: 20240285576Abstract: A method of treating pain, by administering an effective amount of a composition of MDMA, enantiomers thereof (R-MDMA, S-MDMA), a unique mixture of enantiomers (not 1:1), MDMA-like compounds, prodrugs of MDMA, enantiomers, or MDMA-like compounds, analogs thereof, derivatives thereof, or salts thereof to an individual, and treating pain in the individual.Type: ApplicationFiled: January 24, 2024Publication date: August 29, 2024Applicant: Mind Medicine, Inc.Inventor: Gennady N. SMAGIN
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Patent number: 12036220Abstract: A solid oral immediate release formulation of LSD, wherein the composition is produced by lyophilization of a feedstock in a pre-formed mold to form an orally disintegrating tablet. A method of making a solid oral immediate release formulation of LSD by lyophilizing a flash frozen stock solution of LSD and excipients, including a non-gelling matrix former, filler, and binder in a pre-formed mold, and forming an orally disintegrating tablet. A method of treating an individual by administering a solid oral immediate release formulation of LSD, wherein the composition is produced by lyophilization of a feedstock in a pre-formed mold to form an orally disintegrating tablet and treating the individual.Type: GrantFiled: April 3, 2023Date of Patent: July 16, 2024Assignee: Mind Medicine, Inc.Inventors: Peter Mack, Timm Trenktrog, Dustin Melton, Bethany Amber Doty, Jon Schroeder, Lisa Marie Garrett
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Publication number: 20240174594Abstract: A composition of a compound represented by FIGS. 1A-1E for use in substance-assisted therapy. A method of changing neurotransmission, by administering a pharmaceutically effective amount of a compound of FIGS. 1A-1E to a mammal, interacting with serotonin 5-HT2A receptors in the mammal, and inducing psychoactive effects. A method of treating a patient having adverse reactions to psychedelics by administering 4-alkenyl and 4-alkynyl phenethylamine derivatives and related compounds as represented in FIGS. 1A-1E to the patient, and avoiding adverse effects present with psychedelics. A method of changing neurotransmission of an individual, by administering 4-alkenyl and 4-alkynyl phenethylamine derivatives and related compounds as represented in FIGS. 1A-1E and changing neurotransmission in the individual.Type: ApplicationFiled: October 24, 2023Publication date: May 30, 2024Applicant: Mind Medicine, Inc.Inventors: Daniel TRACHSEL, Matthias Emanuel LIECHTI, Felix LUSTENBERGER
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Publication number: 20240115710Abstract: A method of synthesizing a pharmacological compound substance by attaching a psychoactive base substance to an amino acid and creating a prodrug with modified pharmacological behavior. A prodrug made by the method. A pharmaceutical composition comprising a prodrug of a psychoactive base substance attached to an amino acid and a pharmaceutically acceptable salt.Type: ApplicationFiled: December 18, 2023Publication date: April 11, 2024Applicant: Mind Medicine, Inc.Inventors: Daniel TRACHSEL, Matthias Emanuel LIECHTI, Felix LUSTENBERGER
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Patent number: 11896670Abstract: A method of synthesizing a pharmacological compound substance by attaching a psychoactive base substance to an amino acid and creating a prodrug with modified pharmacological behavior. A prodrug made by the method. A pharmaceutical composition comprising a prodrug of a psychoactive base substance attached to an amino acid and a pharmaceutically acceptable salt.Type: GrantFiled: August 23, 2022Date of Patent: February 13, 2024Assignee: Mind Medicine, Inc.Inventors: Daniel Trachsel, Matthias Emanuel Liechti, Felix Lustenberger
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Publication number: 20240010628Abstract: A method of manufacturing R-MDMA by forming a Grignard reagent from 5-bromobenzodioxole, treating the Grignard reagent with S-propylene oxide to form chirally pure alcohol 1, activating the alcohol as mesylate 2, converting to chirally pure azide 3, reducing the azide to amine 4, protecting the amine with di-tert-butyl dicarbonate, reducing the protected amine 5 to yield R-MDMA free base 6, and treating with an acid to form a salt 7 in >99% e.e. A method of manufacturing S-MDMA by forming a Grignard reagent from 5-bromobenzodioxole, treating the Grignard reagent with R-propylene oxide to form chirally pure alcohol 8, activating the alcohol as mesylate 9, converting to chirally pure azide 10, reducing the azide to amine 11, protecting the amine with di-tert-butyl dicarbonate, reducing the protected amine 12 to yield S-MDMA free base 13, and treating with an acid to form a salt 14 in >99% e.e.Type: ApplicationFiled: June 29, 2023Publication date: January 11, 2024Applicant: Mind Medicine, Inc.Inventors: Stephen E. SCHNEIDER, Derek LONDESBROUGH
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Publication number: 20230414583Abstract: A composition of a compound represented generically by FIG. 1A for use in substance-assisted therapy. A method of changing neurotransmission, by administering a pharmaceutically effective amount of a compound of FIG. 1A to a mammal, interacting with serotonin 5-HT2A receptors in the mammal, in particular also human beings, and inducing psychoactive effects. A method of treating an individual, by administering a pharmaceutically effective amount of a compound of FIG. 1A to the individual and treating the individual.Type: ApplicationFiled: June 19, 2023Publication date: December 28, 2023Applicant: Mind Medicine, Inc.Inventors: Daniel TRACHSEL, Matthias Emanuel Liechti, Felix Lustenberger
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Publication number: 20230355575Abstract: A compound including a prodrug having a psychoactive base substance attached to an amino acid. A method of treating an individual, especially in substance-assisted psychotherapy, by administering proMDMA or a proMDMA-like compound to the individual, metabolizing the prodrug, and releasing the MDMA or MDMA-like substance in the individual. A method of reducing anxiety while administering MDMA, by providing a slow release of MDMA or an MDMA-like substance and thereby reducing anxiety in the individual at the onset of administration. A method of personalized medicine, by evaluating an individual and determining if there are characteristics of the individual present that would not be suitable for MDMA treatment and administering proMDMA or a proMDMA-like substance to the individual. A method of reducing abuse of MDMA, by administering proMDMA or a proMDMA-like substance, and providing a delayed and attenuated effect of MDMA or a MDMA-like substance, thereby reducing abuse.Type: ApplicationFiled: May 16, 2023Publication date: November 9, 2023Applicant: Mind Medicine, Inc.Inventors: Matthias Emanuel LIECHTI, Felix LUSTENBERGER, Daniel TRACHSEL
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Publication number: 20230346645Abstract: A method of dosing a psychedelic that avoids the side effects of hallucinations and perceptual disturbances by administering the psychedelic to an individual in a titrating dosing regimen and reducing side effects of hallucinations and perceptual disturbances. A kit for administering a titrating dosing regimen of a psychedelic, including a pharmaceutically effective amount of the psychedelic in dosage forms separated in packaging according to dose and time of administration in a titrating dosing regimen, and instructions for use. A method of treating an individual with psychedelics, by administering the psychedelic to the individual having a condition or disease in a titrating dosing regimen and reducing side effects of hallucinations and perceptual disturbances during treatment.Type: ApplicationFiled: May 1, 2022Publication date: November 2, 2023Applicant: Mind Medicine, Inc.Inventors: Robert Barrow, Daniel R. Karlin
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Publication number: 20230310368Abstract: A composition for use in psychotherapeutic or medical treatment of an R(?) enantiomer of MDMA or MDA. A method of treating an individual for a medical condition (especially autism and social anxiety disorders), by administering an effective amount of a composition of an R(?) enantiomer of MDMA or MDA and treating the individual. A method of reducing neurotoxicity of MDMA and MDA, by administering an effective amount of a composition of an R(?) enantiomer of MDMA or MDA to an individual and reducing neurotoxicity of MDMA or MDA while treating the individual. A method of reducing hyperthermia of MDMA and MDA. A method of reducing physical dependence or abuse liability of MDMA and MDA.Type: ApplicationFiled: June 8, 2023Publication date: October 5, 2023Applicant: Mind Medicine, Inc.Inventors: Robert BARROW, Daniel R. Karlin, Gennady N. Smagin
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Publication number: 20230303572Abstract: A composition including a salt of 18-MC, wherein the salt is chosen from gentisate, hydrobromide, besylate, napadisylate, hydrochloride, sulfate, oxalate, maleate, mesylate, and tosylate. A composition including a polymorph of 18-MC.Type: ApplicationFiled: March 1, 2023Publication date: September 28, 2023Applicant: Mind Medicine, Inc.Inventors: Jeanne BONELLE, Daniel Emil LEVY, Ann NEWMAN, Stephen E. SCHNEIDER
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Publication number: 20230301985Abstract: A method of treating movement disorders, by administering an effective amount of a psychedelic to an individual having a movement disorder, and treating the movement disorder.Type: ApplicationFiled: May 16, 2023Publication date: September 28, 2023Applicant: Mind Medicine, Inc.Inventors: Robert BARROW, Daniel R. KARLIN, Gennady SMAGIN
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Publication number: 20230285359Abstract: A composition of psilocin that is stable including at least one agent or chemical modification that provides enhanced stability. A method making stable psilocin, by providing a formulation of psilocin including at least one agent or chemical modification that provides enhanced stability. A method of treatment of a disease or condition, by administering a composition of psilocin that is stable to an individual and treating the disease or condition.Type: ApplicationFiled: May 31, 2023Publication date: September 14, 2023Applicant: Mind Medicine, Inc.Inventors: Robert BARROW, Peter MACK, Stephen SCHNEIDER, Jon SCHROEDER, Gerald S. JONES
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Publication number: 20230285327Abstract: A composition of a compound represented by FIG. 1 for use in substance-assisted therapy. A method of changing neurotransmission, by administering a pharmaceutically effective amount of a compound of FIG. 1 to a mammal, interacting with serotonin 5-HT2A receptors in the mammal, in particular also human beings, and inducing psychoactive effects. A method of treating a patient having adverse reactions to psychedelics by administering a desoxyscaline derivative to the patient, and avoiding adverse effects present with psychedelics. A method of changing neurotransmission of an individual, by administering a desoxyscaline derivative, and changing neurotransmission in the individual.Type: ApplicationFiled: May 12, 2023Publication date: September 14, 2023Applicant: Mind Medicine, Inc.Inventors: Daniel TRACHSEL, Matthias Emanuel LIECHTI, Felix LUSTENBERGER
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Publication number: 20230285386Abstract: A solid oral immediate release formulation of LSD, including LSD contained within a dosage form of a capsule, tablet, or orally disintegrating tablet. A method of making a solid oral immediate release formulation of LSD as a free base or in a salt form by granulation, including moisture-activated dry granulation or dry blending. A method of treating an individual, by administering a solid oral immediate release formulation of LSD and treating the individual.Type: ApplicationFiled: May 18, 2023Publication date: September 14, 2023Applicant: Mind Medicine, Inc.Inventors: Peter MACK, Dustin MELTON, Bethany Amber DOTY, Jon SCHROEDER, James COGHILL, Daniel Emil LEVY
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Publication number: 20230233688Abstract: A compound including a prodrug having a psychoactive base substance attached to an amino acid. A method of treating an individual, by administering proMDMA, a proMDMA-like compound, or proR(-)MDMA to the individual, metabolizing the prodrug, and releasing the MDMA or MDMA-like substance in the individual. A method of reducing anxiety while administering MDMA, by providing a slow release of MDMA, an MDMA-like substance or R(-)MDMA thereby reducing anxiety in the individual at the onset of administration. A method of personalized medicine, by evaluating an individual and determining if there are characteristics present that would not be suitable for MDMA treatment and administering proMDMA, a proMDMA-like substance, or proR(-)MDMA to the individual. A method of reducing abuse of MDMA, by administering proMDMA, a proMDMA-like substance, or proR(-)MDMA, and providing a delayed and attenuated effect of MDMA or a MDMA-like substance, thereby reducing abuse.Type: ApplicationFiled: March 28, 2023Publication date: July 27, 2023Applicant: Mind Medicine, Inc.Inventors: Matthias Emanuel LIECHTI, Felix LUSTENBERGER, Daniel TRACHSEL
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Publication number: 20230226019Abstract: A composition for use in psychotherapeutic or medical treatment of an R(?) enantiomer of MDMA or MDA. A method of treating an individual for a medical condition (especially autism and social anxiety disorders), by administering an effective amount of a composition of an R(?) enantiomer of MDMA or MDA and treating the individual. A method of reducing neurotoxicity of MDMA and MDA, by administering an effective amount of a composition of an R(?) enantiomer of MDMA or MDA to an individual and reducing neurotoxicity of MDMA or MDA while treating the individual. A method of reducing hyperthermia of MDMA and MDA. A method of reducing physical dependence or abuse liability of MDMA and MDA.Type: ApplicationFiled: March 20, 2023Publication date: July 20, 2023Applicant: Mind Medicine, Inc.Inventors: Robert BARROW, Daniel R. KARLIN
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Publication number: 20230227398Abstract: A composition for use in substance-assisted therapy, wherein: R is hydrogen, methyl, or ethyl, and R? is C1-C5 branched or unbranched alkyl with the alkyl optionally substituted with F1-F5 fluorine substituents up to a fully fluorinated alkyl, C3-C6 cycloalkyl optionally and independently substituted with one or more substituents such as F1-F5 fluorine and/or C1 - C2 alkyl, (C3-C6 cycloalkyl)-C1-C2 branched or unbranched alkyl optionally substituted with one or more substituents such as F1-F5 fluorine and/or C1-C2 alkyl, or C2-C5 branched or unbranched alkenyl with E or Z vinylic, cis or trans allylic, E or Zallylic or other double bond position in relation to the attached ether function, where any of the carbons of the branched or unbranched alkenyl substituent is optionally substituted independently with one or more C1-C2 alkyl, with F1-F5 fluorine or with D1-D5 deuteron substituents.Type: ApplicationFiled: March 27, 2023Publication date: July 20, 2023Applicant: Mind Medicine, Inc.Inventors: Daniel TRACHSEL, Matthias Emanuel LIECHTI, Felix LUSTENBERGER