Abstract: DNA encoding a recombinant antibody molecule end-specific for an amyloid-&bgr; peptide, pharmaceutical compositions thereof, and a method for preventing the accumulation of amyloid-&bgr; peptides in the extracellular milieu of neurons by causing an end-specific antibody to come into contact with such amyloid-&bgr; peptides. Such a method is useful for preventing or inhibiting progression of Alzheimer's Disease.