Abstract: The accuracy of drug delivery with drug pump devices may be improved by a combination of pump operation at high flow resistances and pump pressures, pressure-relief mechanisms, and sensor-based feedback for pump control.

Abstract: The accuracy of drug delivery with drug pump devices may be improved by a combination of pump operation at high flow resistances and pump pressures, pressure-relief mechanisms, and sensor-based feedback for pump control.

Abstract: Implanted drug pump devices can be refilled via a fill port in the drug reservoir that includes a self-resealable septum.

Abstract: A system for refilling the drug reservoir of an implanted drug pump device may facilitate wireless data exchange between the refill system and the implanted device, e.g., to verify proper drug selection prior to commencement of the refill process.

Abstract: Implanted drug pump devices can be refilled with a refill needle inserted through a fill port in the drug reservoir of the drug pump device. Proper needle insertion may be verified visually or using electrical, magnetic, optical, acoustic, or other suitable sensing mechanisms.

Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.

Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.

Abstract: Drug pump devices may be remotely controlled and/or reprogrammed by a smartphone or other wireless handheld device.

Abstract: Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon.

Abstract: Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula.

Abstract: Electrolytically driven drug pump devices may be configured so as to ensure sustained contact of the electrolysis electrodes with the electrolyte, thereby improving the reliability and/or pump capacity of the devices.

Abstract: A miniaturized drug pump can actively dispense fluid at a controlled (or controllable) flow rate emerging at or near the distal tip of a catheter.

Abstract: Drug pump devices may be remotely controlled and/or reprogrammed by a smartphone or other wireless handheld device.

Abstract: In piston-pump drug-delivery devices, changes in friction between the piston and vial in which it moves may be reduced and/or compensated for by suitable surface coatings and/or feedback control.

Abstract: The filling status of a drug reservoir in a drug pump devices may be determined with mechanical and/or magnetic position sensor associated with a reservoir boundary.