Patents Assigned to Ministero dell'Universita e delle Ricerca Scientifica e Tecnologica
  • Process for the synthesis of the levodopa
    Patent number: 4962223
    Abstract: New process for the synthesis of the levodopa, L-(-)-2-amino-3-(3,4-dihydyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with d-camphorsulfonic acid, or with a salt thereof, the d,l-2-amino-3-(3,4-dimethoxyphenyl)propionitrile, obtained from the 3,4-dimethoxyphenylacetaldehyde, and in the subsequent hydrolysis and demethylation, by means of concentrated solutions of haloid acids, of the d-2-amino-3-(3,4-dimethoxyphenyl)propionitrile and of salts thereof.
    Type: Grant
    Filed: July 3, 1989
    Date of Patent: October 9, 1990
    Assignee: Ministero dell'Universita e delle Ricerca Scientifica e Tecnologica
    Inventors: Vincenzo Cannata, Giancarlo Tamerlani, Mauro Morotti