Abstract: Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.
Type:
Application
Filed:
March 27, 2023
Publication date:
March 28, 2024
Applicant:
MiNK Therapeutics, Inc.
Inventors:
Marc van Dijk, Volker Seibert, Cornelia Anne Mundt, Arthur Andrew Hurwitz, Mark Adrian Exley, Benjamin Jacob Wolf, Daniel Leventhal, Sébastien Lalevée, Reed Masakayan
Abstract: Provided herein are engineered host cells suitable for expression of functional T cell receptors (TCR) and methods of using these cells to identify TCRs that specifically bind to a desired peptide-major histocompatibility complex (MHC) complex.
Type:
Grant
Filed:
September 9, 2016
Date of Patent:
February 13, 2024
Assignee:
MiNK Therapeutics, Inc.
Inventors:
Marc Van Dijk, Volker Seibert, Robert Benjamin Stein
Abstract: Provided are TCRs (e.g., TCRs that bind to MLL, e.g., TCRs that bind to an MLL phosphopeptide, e.g., TCRs that bind to an MLL phosphopeptide/MHC complex), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.
Type:
Grant
Filed:
March 3, 2020
Date of Patent:
August 8, 2023
Assignee:
MiNK Therapeutics, Inc.
Inventors:
Marc van Dijk, Ekaterina Vladimirovna Breous-Nystrom, Alessandra Franchino, Sébastien Lalevée, Arthur Andrew Hurwitz, Mark Adrian Exley, Benjamin Jacob Wolf
Abstract: Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.
Type:
Grant
Filed:
July 15, 2019
Date of Patent:
March 28, 2023
Assignee:
MiNK Therapeutics, Inc.
Inventors:
Marc van Dijk, Volker Seibert, Cornelia Anne Mundt, Arthur Andrew Hurwitz, Mark Adrian Exley, Benjamin Jacob Wolf, Daniel Leventhal, Sébastien Lalevée, Reed Masakayan