Patents Assigned to Mipsalus ApS
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Patent number: 11879027Abstract: Disclosed is agents and methods that target metabolism malfunctions, inborne as well as acquired, as well as methods for preparation of the agents. In particular, the invention relates to methods for preparing molecular imprinted polymers with high binding capacity for phenylalanine or tyrosine, MIPs that bind phenylalanine or tyrosine, and methods for treating phenylketonuria, alkaptonuria, and hypertyrosinemia.Type: GrantFiled: May 11, 2021Date of Patent: January 23, 2024Assignee: MIPSALUS APSInventors: Klaus Gregorius, Nicolas Otto Krogh
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Patent number: 11549948Abstract: Disclosed is a FRET based assay and related products. The assay employs molecular imprinted polymers having a very high affinity for their target.Type: GrantFiled: March 15, 2017Date of Patent: January 10, 2023Assignee: MIPSALUS APSInventors: Nicolas Otto Krogh, Klaus Gregorius, Elena Fernandez Laborda
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Patent number: 11028203Abstract: Disclosed is agents and methods that target metabolism malfunctions, inborne as well as acquired, as well as methods for preparation of the agents. In particular, the invention relates to methods for preparing molecular imprinted polymers with high binding capacity for phenylalanine or tyrosine, MIPs that bind phenylalanine or tyrosine, and methods for treating phenylketonuria, alkaptonuria, and hypertyrosinemia.Type: GrantFiled: June 29, 2018Date of Patent: June 8, 2021Assignee: Mipsalus APSInventors: Klaus Gregorius, Nicolas Otto Krogh
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Publication number: 20200166516Abstract: Disclosed is a FRET based assay and related products. The assay employs molecular imprinted polymers having a very high affinity for their target.Type: ApplicationFiled: March 15, 2017Publication date: May 28, 2020Applicant: Mipsalus ApSInventors: Nicolas Otto Krogh, Klaus Gregorius, Elena Fernandez Laborda
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Patent number: 9212271Abstract: Provided is an improved method for preparation of insoluble molecular imprinted polymers (MIPs), the method comprising: a) providing soluble or semi-soluble MIPs that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble MIPs provided in step a so as to obtain insoluble template agent binding MIPs, and c) optionally isolating, concentrating or purifying the MIPs obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the MIPs provided in step a are indeed all binders of the template.Type: GrantFiled: February 28, 2012Date of Patent: December 15, 2015Assignee: Mipsalus APSInventors: Klaus Gregorius, Ian Alan Nicholls, Nicolas Otto Krogh
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Patent number: 9149737Abstract: Disclosed is a method for preparing a composition enriched for receptors (typically molecular impringet polymers, MIPs) that bind an agent, where said receptors each specifically bind at least two discrete sites on said agent, by subjecting a sample of receptors to a first step of affinity purification with the agent where one binding site on the agent is non-accessible for binding to the receptors and subsequently subjecting the purified receptors to at least one further step of affinity purification with the agent where a second binding site on the agent is non-accessible.Type: GrantFiled: September 16, 2010Date of Patent: October 6, 2015Assignee: Mipsalus ApSInventors: Nicolas Otto Krogh, Klaus Gregorius
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Publication number: 20150031779Abstract: Provided is an improved method for preparation of insoluble molecular imprinted polymers (MIPs), the method comprising: a) providing soluble or semi-soluble MIPs that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble MIPs provided in step a so as to obtain insoluble template agent binding MIPs, and c) optionally isolating, concentrating or purifying the MIPs obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the MIPs provided in step a are indeed all binders of the template.Type: ApplicationFiled: February 28, 2012Publication date: January 29, 2015Applicant: Mipsalus APSInventors: Klaus Gregorius, Ian Alan Nicholls, Nicolas Otto Krogh
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Patent number: 8287908Abstract: One aspect is a method for improved preparation of molecular imprinted polymer (MIP) particles, where initial compositions comprising insoluble MIP particles are enriched for those MIP particles that bind a particular target molecule, thus excluding non-binding and weakly binding particles from the final composition. Enrichment is typically accomplished via use of chromatographic methods capable of separating particulate material or by means of agglutination. Another aspect is preparation of improved insoluble MIPs by use of extended micronization of raw MIP particles with a view to expose a large number of binding sites per mass unit of MIP particles. In preferred embodiments the two aspects are combined. The resulting improved MIPs may be used for diagnostic, analytical and therapeutic purposes, notably as orally administered drugs which can bind substances such as cholesterol and bile acids and bile acid salts in the gastrointestinal tract.Type: GrantFiled: February 21, 2007Date of Patent: October 16, 2012Assignee: Mipsalus ApSInventors: Jesper S. Kristensen, Klaus G. Nielsen, Nicholas O. Krogh
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Publication number: 20120171154Abstract: Disclosed is a method for preparing a composition enriched for receptors (typically molecular impringet polymers, MIPs) that bind an agent, where said receptors each specifically bind at least two discrete sites on said agent, by subjecting a sample of receptors to a first step of affinity purification with the agent where one binding site on the agent is non-accessible for binding to the receptors and subsequently subjecting the purified receptors to at least one further step of affinity purification with the agent where a second binding site on the agent is non-accessible.Type: ApplicationFiled: September 16, 2010Publication date: July 5, 2012Applicant: Mipsalus ApSInventors: Nicolas Otto Krogh, Klaus Gregorius
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Publication number: 20090104277Abstract: One aspect is a method for improved preparation of molecular imprinted polymer (MIP) particles, where initial compositions comprising insoluble MIP particles are enriched for those MIP particles that bind a particular target molecule, thus excluding non-binding and weakly binding particles from the final composition. Enrichment is typically accomplished via use of chromatographic methods capable of separating particulate material or by means of agglutination. Another aspect is preparation of improved insoluble MIPs by use of extended micronization of raw MIP particles with a view to expose a large number of binding sites per mass unit of MIP particles. In preferred embodiments the two aspects are combined. The resulting improved MIPs may be used for diagnostic, analytical and therapeutic purposes, notably as orally administered drugs which can bind substances such as cholesterol and bile acids and bile acid salts in the gastrointestinal tract.Type: ApplicationFiled: February 21, 2007Publication date: April 23, 2009Applicant: MIPSALUS APSInventors: Jesper Svenning Kristensen, Klaus Gregorius Nielsen, Nicolas Otto Krogh