Patents Assigned to Mirus Bio LLC
  • Cationic cyclic amine and amphipathic transfection reagents
    Patent number: 11739174
    Abstract: Cationic cyclic amine containing polymers and copolymers as well as novel lipids have been designed and synthesized for efficient delivery of nucleic acids to cells in biological systems, specifically for in vitro cell transfection research.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: August 29, 2023
    Assignee: Mirus Bio LLC
    Inventors: Nicholas A. A. Rossi, Anatoly Pinchuk, Karen Neder, James Ludtke, Laura Juckem
  • CATIONIC CYCLIC AMINE AND AMPHIPATHIC TRANSFECTION REAGENTS
    Publication number: 20210269570
    Abstract: Cationic cyclic amine containing polymers and copolymers as well as novel lipids have been designed and synthesized for efficient delivery of nucleic acids to cells in biological systems, specifically for in vitro cell transfection research.
    Type: Application
    Filed: February 21, 2020
    Publication date: September 2, 2021
    Applicant: Mirus Bio LLC
    Inventor: Nicholas A. A. Rossi
  • Cationic cyclic amine and amphipathic transfection reagents
    Patent number: 10619162
    Abstract: Cationic cyclic amine containing polymers and copolymers as well as novel lipids have been designed and synthesized for efficient delivery of nucleic acids to cells in biological systems, specifically for in vitro cell transfection research.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: April 14, 2020
    Assignee: Mirus Bio LLC
    Inventor: Nicholas A. A. Rossi
  • Cationic acrylamide copolymer transfection reagents
    Patent number: 9677077
    Abstract: Cationic acrylamide copolymers have been designed and synthesized for highly efficient delivery of nucleic acids to cells in biological systems, specifically for in vitro cell transfection research.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 13, 2017
    Assignee: Mirus Bio LLC
    Inventor: Nicholas A. A. Rossi
  • Transfection compositions using amphipathic compounds
    Patent number: 8921448
    Abstract: A low toxicity, highly efficient transfection composition is described with an amphipathic compound containing at least one imidazole. The composition may be used in the process of transfecting nucleic acids into an animal cell.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: December 30, 2014
    Assignee: Mirus Bio LLC
    Inventors: Shannon E. Bruse, Laura K Juckem, Karen M Neder
  • Method for single-step attachment of a label to target molecules
    Patent number: 8129509
    Abstract: Compounds and methods are provided for a single-step covalent attachment of a label to a molecule comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then, combining the covalently attachable labeling reagent with a mixture containing the molecule, under conditions wherein the labeling reagent has reactivity with the molecule thereby forming a covalent bond.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: March 6, 2012
    Assignee: Mirus Bio LLC
    Inventors: Paul M. Slattum, Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker
  • Compositions and processes using siRNA, amphipathic compounds and polycations
    Patent number: 7601367
    Abstract: Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: October 13, 2009
    Assignee: Mirus Bio LLC
    Inventors: Sean D. Monahan, David L. Lewis, Hans Herweijer, Jon A. Wolff, James E. Hagstrom, Aaron G. Loomis, Vladimir Trubetskoy, Lori Higgs
  • Gene expression with covalently modified polynucleotides
    Patent number: 7491538
    Abstract: A process and compound wherein nucleic acids can be modified with a host of molecules and maintain their ability to be expressed. A modifying chemical attachment of polyions to polynucleotides can be used to facilitate the change of tertiary structure of the nucleic acid and in some cases condensation of nucleic acids into smaller, charged particles useful in delivering the nucleic acid to a cell.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: February 17, 2009
    Assignee: Mirus Bio LLC
    Inventors: Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Paul M. Slattum
  • Protein and peptide delivery to mammalian cells in vitro
    Patent number: 7476401
    Abstract: Compositions and methods for delivery of proteins and peptides to mammalian cells in vitro are described. Specifically, polypeptide-surfactant complexes formed from noncovalent hydrophobation of polypeptides and reversible hydrophobic modification of polypeptides are described. The compositions can be used to delivery positively charged, negatively charged and charge neutral polypeptides to cells.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: January 13, 2009
    Assignee: Mirus Bio LLC
    Inventors: Sean D. Monahan, Vladimir G. Budker, Kirk Ekena, Lisa Nader