Abstract: A process for delivering a polynucleotide to a parenchymal cell in a mammal by injecting the polynucleotide into a blood vessel connected to the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell and functionally expressed to therapeutic levels.
Type:
Grant
Filed:
November 21, 1997
Date of Patent:
July 24, 2001
Assignee:
Mirus, Inc.
Inventors:
Jon A. Wolff, Vladimir Budker, Stuart J. Knechtle
Abstract: Compounds and methods are provided for a single-step covalent attachment of a label to a molecule comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then, combining the covalently attachable labeling reagent with a mixture containing the molecule, under conditions wherein the labeling reagent has reactivity with the molecule thereby forming a covalent bond.
Type:
Grant
Filed:
December 2, 1997
Date of Patent:
July 17, 2001
Assignee:
Mirus, Inc.
Inventors:
Jon A. Wolff, James E. Hagstrom, Paul Michael Slattum, Vladimir Budker
Abstract: The described invention relates to methods for covalently attaching a compound to a gene. The method provides for covalently attaching compounds to genes for enhancing the cellular transport of the genes to predetermined targets, while maintaining the gene's functionality.
Type:
Grant
Filed:
December 12, 1997
Date of Patent:
July 25, 2000
Assignee:
Mirus, Inc.
Inventors:
Jon A. Wolff, James E. Hagstrom, Magdolna G. Sebestyen, Vladimir Budker
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