Abstract: The present invention relates to a process for preparing a melanogenic inhibitor and a pigmentation-lightening agent containing the same, more particularly, the present invention relates to a process for preparing a novel melanogenic inhibitor which is obtained by proliferating an established cell line from a warm-blooded animal, homogenizing the proliferated cells and recovering the same from the resultant homogenate, as well as to a pigmentation-lightening agent containing the same.