Abstract: A screening device that screens for the presence or absence of one or more substances in a mammalian body is disclosed. The device includes a plurality of electrodes, and a biosensor assembly having a reference region and at least one sensor region. The reference region includes at least one microneedle and microchannel, and each sensor region includes at least one microneedle and microchannel, and is sensitive to a specific substance. Each sensor microchannel in a respective sensor region includes a specific assay ligand that may bond with the particular substance to be sensed. Also disclosed is a method for the screening for the presence or absence of one or more substances in the mammalian body.

Abstract: Novel multichannel ionosonic devices with microneedle arrays incorporated into the devices for transdermal and intradermal delivery are described. In an embodiment, the ionosonic device includes a multichannel ionophoretic driver used in combination with a multichannel dispersion electrode integrated with ultrasonic elements and microneedle array elements mounted on a single application electrode. The ionosonic-microneedle transdermal device can be configured in a variety of shapes and structural flexibility for the treatment of skin and systemic disorders through the intradermal and transdermal delivery of one or more of a variety of therapeutic and modulating agents. Because of enhanced transdermal penetration this device offers the transdermal delivery of therapeutic peptides is getting closer to reality.